{"id":"https://openalex.org/W2059928307","doi":"https://doi.org/10.1016/j.mrgentox.2012.03.002","title":"Toxicogenomics: The challenges and opportunities to identify biomarkers, signatures and thresholds to support mode-of-action","display_name":"Toxicogenomics: The challenges and opportunities to identify biomarkers, signatures and thresholds to support mode-of-action","publication_year":2012,"publication_date":"2012-03-13","ids":{"openalex":"https://openalex.org/W2059928307","doi":"https://doi.org/10.1016/j.mrgentox.2012.03.002","mag":"2059928307","pmid":"https://pubmed.ncbi.nlm.nih.gov/22445948"},"language":"en","primary_location":{"id":"doi:10.1016/j.mrgentox.2012.03.002","doi":"https://doi.org/10.1016/j.mrgentox.2012.03.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2012.03.002","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088596046","display_name":"Richard A. Currie","orcid":"https://orcid.org/0000-0002-6528-3326","observed_orcids":["https://orcid.org/0000-0002-6528-3326"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard A. Currie","raw_affiliation_strings":["Syngenta International Research Centre, Bracknell RG42 6EY, UK. Richard.currie@syngenta.com","Syngenta International Research Centre, Bracknell RG42 6EY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta International Research Centre, Bracknell RG42 6EY, UK. Richard.currie@syngenta.com","institution_ids":["https://openalex.org/I4210087094"]},{"raw_affiliation_string":"Syngenta International Research Centre, Bracknell RG42 6EY, UK","institution_ids":["https://openalex.org/I4210087094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088596046"],"corresponding_institution_ids":["https://openalex.org/I4210087094"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":1.5873,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82663269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"746","issue":"2","first_page":"97","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.42480000853538513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.42480000853538513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxicogenomics","display_name":"toxicogenomics","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.703000009059906},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bradford-hill-criteria","display_name":"Bradford Hill criteria","score":0.7799999713897705},{"id":"https://openalex.org/keywords/threshold-response","display_name":"threshold response","score":0.5529999732971191},{"id":"https://openalex.org/keywords/batch-to-batch-variability","display_name":"batch-to-batch variation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/microarray-quality-control","display_name":"microarray quality control","score":0.6549999713897705},{"id":"https://openalex.org/keywords/data-interpretation","display_name":"data interpretation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.4429999887943268},{"id":"https://openalex.org/keywords/network-motifs","display_name":"network motifs","score":0.671999990940094},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"positive feedback","score":0.722000002861023},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hazard-identification","display_name":"hazard identification","score":0.8550000190734863},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.9200563430786133},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.5984176397323608},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5063432455062866},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5018577575683594},{"id":"https://openalex.org/C48677424","wikidata":"https://www.wikidata.org/wiki/Q6888088","display_name":"Mode (computer interface)","level":2,"score":0.41279157996177673},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.39819687604904175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35280102491378784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2876521348953247},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.19459697604179382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0981903076171875},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.08885031938552856},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08451008796691895},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D015386","descriptor_name":"Hazardous Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015386","descriptor_name":"Hazardous Substances","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mrgentox.2012.03.002","doi":"https://doi.org/10.1016/j.mrgentox.2012.03.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2012.03.002","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},{"id":"pmid:22445948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22445948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1561767438","https://openalex.org/W1568390176","https://openalex.org/W1599207601","https://openalex.org/W1966043817","https://openalex.org/W1969779341","https://openalex.org/W1974068770","https://openalex.org/W1976324983","https://openalex.org/W1982329071","https://openalex.org/W1987391689","https://openalex.org/W1989712725","https://openalex.org/W1995121576","https://openalex.org/W2010637767","https://openalex.org/W2018363585","https://openalex.org/W2021560851","https://openalex.org/W2037247915","https://openalex.org/W2039070959","https://openalex.org/W2046264770","https://openalex.org/W2051262075","https://openalex.org/W2051262326","https://openalex.org/W2052021946","https://openalex.org/W2062060692","https://openalex.org/W2079632667","https://openalex.org/W2099705602","https://openalex.org/W2100019433","https://openalex.org/W2108590677","https://openalex.org/W2108856743","https://openalex.org/W2112666597","https://openalex.org/W2118610649","https://openalex.org/W2123333705","https://openalex.org/W2126004304","https://openalex.org/W2135167572","https://openalex.org/W2136188768","https://openalex.org/W2139439234","https://openalex.org/W2146976723","https://openalex.org/W2149720473","https://openalex.org/W2150220223","https://openalex.org/W2153624566","https://openalex.org/W2155491988","https://openalex.org/W2155606851","https://openalex.org/W2155858104","https://openalex.org/W2158019367","https://openalex.org/W2167062654","https://openalex.org/W4229791719","https://openalex.org/W4247938048","https://openalex.org/W4248547118","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2478648296","https://openalex.org/W2353370625","https://openalex.org/W2122728622","https://openalex.org/W3016893324","https://openalex.org/W2034912498","https://openalex.org/W2171062114","https://openalex.org/W2035772003","https://openalex.org/W2090106817","https://openalex.org/W1500323645","https://openalex.org/W2051385700"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
