{"id":"https://openalex.org/W2059923680","doi":"https://doi.org/10.1053/jhep.2003.50066","title":"Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection","display_name":"Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2059923680","doi":"https://doi.org/10.1053/jhep.2003.50066","mag":"2059923680","pmid":"https://pubmed.ncbi.nlm.nih.gov/12540779"},"language":"en","primary_location":{"id":"doi:10.1053/jhep.2003.50066","doi":"https://doi.org/10.1053/jhep.2003.50066","is_oa":false,"landing_page_url":"https://doi.org/10.1053/jhep.2003.50066","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111554008","display_name":"Xiu\u2010Da Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiu-Da Shen","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045209569","display_name":"Bibo Ke","orcid":"https://orcid.org/0000-0002-1885-1538","observed_orcids":["https://orcid.org/0000-0002-1885-1538"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibo Ke","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037211841","display_name":"Yuan Zhai","orcid":"https://orcid.org/0000-0003-0485-4022","observed_orcids":["https://orcid.org/0000-0003-0485-4022"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Zhai","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043951487","display_name":"FENG GUANG GAO","orcid":"https://orcid.org/0000-0003-2371-1799","observed_orcids":["https://orcid.org/0000-0003-2371-1799"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393428","display_name":"Dean M. Anselmo","orcid":"https://orcid.org/0000-0002-3367-8681","observed_orcids":["https://orcid.org/0000-0002-3367-8681"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Anselmo","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005331275","display_name":"Charles Lassman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles R. Lassman","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111860699","display_name":"Ronald W. Busuttil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald W. Busuttil","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016218484","display_name":"Jerzy W. Kupiec\u2010Weglinski","orcid":"https://orcid.org/0000-0001-8976-4872","observed_orcids":["https://orcid.org/0000-0001-8976-4872"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerzy W. Kupiec-Weglinski","raw_affiliation_strings":["Dumont\u2010UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont\u2010UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, and Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":9.9067,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98460721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"2","first_page":"296","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.7919999957084656},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.9710000157356262},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/t-cell-mediated-liver-injury","display_name":"T cell-mediated liver injury","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.9750000238418579},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.6150000095367432},{"id":"https://openalex.org/keywords/neutrophil-accumulation","display_name":"neutrophil accumulation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.75},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.6039999723434448},{"id":"https://openalex.org/keywords/warm-ischemia","display_name":"warm ischemia","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.7348244190216064},{"id":"https://openalex.org/C65439459","wikidata":"https://www.wikidata.org/wiki/Q14914618","display_name":"STAT4","level":5,"score":0.6645864248275757},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.49593386054039},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.40433335304260254},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38456225395202637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36835289001464844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3658486604690552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3578813076019287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30575037002563477},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2867060899734497},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.1650037169456482},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008102","descriptor_name":"Liver Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/jhep.2003.50066","doi":"https://doi.org/10.1053/jhep.2003.50066","is_oa":false,"landing_page_url":"https://doi.org/10.1053/jhep.2003.50066","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:12540779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12540779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2091283467","display_name":"CD4+ T REG CELLS IN MAINTENANCE OF TRANSPLANT TOLERANCE","funder_award_id":"R01AI042223","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4998903197","display_name":"COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS","funder_award_id":"R01AI023847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898292","display_name":"HuR/HIF \u2013 SIRT1 Signaling Axis in Liver Transplant Rejuvenation","funder_award_id":"R01DK062357","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W23360501","https://openalex.org/W162447880","https://openalex.org/W1500284214","https://openalex.org/W1561573262","https://openalex.org/W1970190570","https://openalex.org/W1970974488","https://openalex.org/W1975588465","https://openalex.org/W1978910929","https://openalex.org/W1986625462","https://openalex.org/W1990312588","https://openalex.org/W2006848339","https://openalex.org/W2011198193","https://openalex.org/W2016659406","https://openalex.org/W2018229946","https://openalex.org/W2020941408","https://openalex.org/W2029860358","https://openalex.org/W2041606646","https://openalex.org/W2050881390","https://openalex.org/W2050971607","https://openalex.org/W2053240210","https://openalex.org/W2055600855","https://openalex.org/W2057658272","https://openalex.org/W2058496317","https://openalex.org/W2059829735","https://openalex.org/W2062686390","https://openalex.org/W2062926375","https://openalex.org/W2063067831","https://openalex.org/W2072353087","https://openalex.org/W2077529924","https://openalex.org/W2084256872","https://openalex.org/W2103060185","https://openalex.org/W2105754873","https://openalex.org/W2106507564","https://openalex.org/W2123698136","https://openalex.org/W2135059159","https://openalex.org/W2145530136","https://openalex.org/W2166803343","https://openalex.org/W4250194912"],"related_works":["https://openalex.org/W2036824735","https://openalex.org/W2068326328","https://openalex.org/W1978910929","https://openalex.org/W2016659406","https://openalex.org/W1542718085","https://openalex.org/W2057758077","https://openalex.org/W2077529924","https://openalex.org/W2079777195","https://openalex.org/W2011214569","https://openalex.org/W2059456964"],"abstract_inverted_index":{"Ischemia/reperfusion":[0],"(I/R)":[1],"injury":[2,157,196,218],"remains":[3,227],"an":[4],"important":[5],"problem":[6],"in":[7,23,29,50,95,166,186,197,219],"clinical":[8],"organ":[9],"transplantation.":[10],"There":[11],"is":[12,207],"growing":[13],"evidence":[14],"that":[15],"T":[16,21,65,122,145,150],"lymphocytes,":[17],"and":[18,41,47,97,116,158],"activated":[19],"CD4+":[20],"cells":[22,151],"particular,":[24],"play":[25],"a":[26,55,91],"key":[27],"role":[28,37],"hepatic":[30,155,184,195,216],"I/R":[31,52,77,136,156,199,217],"injury.":[32,53,78],"This":[33],"study":[34],"analyzes":[35],"the":[36,74],"of":[38,43,62,76,81,88,129,141,148,180],"signal":[39],"transducer":[40],"activator":[42],"transcription":[44],"4":[45],"(Stat4)":[46],"Stat6":[48,98],"signaling":[49,131,206],"liver":[51,93],"Using":[54],"partial":[56],"lobar":[57],"warm":[58,82,215],"ischemia":[59,83],"model,":[60],"groups":[61],"wild-type":[63],"(WT),":[64],"cell-deficient,":[66],"Stat4-/Stat6-deficient":[67],"knockout":[68],"(KO)":[69],"mice":[70],"were":[71],"assessed":[72,102],"for":[73],"extent/severity":[75],"Ninety":[79],"minutes":[80],"followed":[84],"by":[85,103,224],"6":[86],"hours":[87],"reperfusion":[89],"induced":[90],"fulminant":[92],"failure":[94],"WT":[96,142],"KO":[99,133,188],"mice,":[100],"as":[101],"hepatocellular":[104],"damage":[105],"(serum":[106],"alanine":[107],"aminotransferase":[108],"[sALT]":[109],"levels),":[110],"neutrophil":[111],"accumulation":[112],"(myeloperoxidase":[113],"[MPO]":[114],"activity)":[115],"histology":[117],"(Suzuki":[118],"scores).":[119],"In":[120,190,203],"contrast,":[121,191],"cell":[123],"deficiency":[124],"(nu/nu":[125],"mice)":[126,134],"or":[127,143],"disruption":[128,212,226],"Stat4":[130,187,201,205,211,225],"(Stat4":[132],"reduced":[135],"insult.":[137],"Unlike":[138],"adoptive":[139],"transfer":[140],"Stat6-deficient":[144],"cells,":[146],"infusion":[147],"Stat4-deficient":[149],"failed":[152],"to":[153],"restore":[154],"prevented":[159],"tumor":[160],"necrosis":[161],"factor":[162],"alpha":[163],"(TNF-alpha)":[164],"production":[165],"nu/nu":[167],"mice.":[168,220],"Diminished":[169],"TNF-alpha/Th1-type":[170],"cytokine":[171],"messenger":[172],"RNA":[173],"(mRNA)/protein":[174],"elaborations":[175],"patterns,":[176],"along":[177],"with":[178],"overexpression":[179],"heme":[181],"oxygenase-1":[182],"(HO-1)-accompanied":[183],"cytoprotection":[185,222],"recipients.":[189],"HO-1":[192],"depression":[193],"restored":[194],"otherwise":[198],"resistant":[200],"KOs.":[202],"conclusion,":[204],"required":[208],"for,":[209],"whereas":[210],"protects":[213],"against,":[214],"The":[221],"rendered":[223],"HO-1-dependent.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}