{"id":"https://openalex.org/W2059905263","doi":"https://doi.org/10.1002/path.1711300405","title":"Giant lysosomes, a cytoplasmic marker in osteoclasts of beige mice","display_name":"Giant lysosomes, a cytoplasmic marker in osteoclasts of beige mice","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W2059905263","doi":"https://doi.org/10.1002/path.1711300405","mag":"2059905263","pmid":"https://pubmed.ncbi.nlm.nih.gov/7391859"},"language":"en","primary_location":{"id":"doi:10.1002/path.1711300405","doi":"https://doi.org/10.1002/path.1711300405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711300405","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017367591","display_name":"Patricia Ash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Ash","raw_affiliation_strings":["MRC Radiobiology Unit, Harwell, Didcot, Oxon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Radiobiology Unit, Harwell, Didcot, Oxon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109206556","display_name":"John Freeman Loutit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. F. Loutit","raw_affiliation_strings":["MRC Radiobiology Unit, Harwell, Didcot, Oxon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Radiobiology Unit, Harwell, Didcot, Oxon","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111538874","display_name":"K. M. S. Townsend","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. M. S. Townsend","raw_affiliation_strings":["MRC Radiobiology Unit, Harwell, Didcot, Oxon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Radiobiology Unit, Harwell, Didcot, Oxon","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.6632,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82975784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"130","issue":"4","first_page":"237","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9679999947547913},{"id":"https://openalex.org/keywords/beige-mice","display_name":"beige mice","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chediak-higashi-syndrome","display_name":"Chediak-Higashi syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lysosome-enlargement","display_name":"lysosome enlargement","score":0.6079999804496765},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/arylsulfatase","display_name":"arylsulfatase","score":0.890999972820282},{"id":"https://openalex.org/keywords/lysosome-fusion","display_name":"lysosome fusion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cytoplasmic-markers","display_name":"cytoplasmic markers","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cba-mice","display_name":"CBA mice","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780549954","wikidata":"https://www.wikidata.org/wiki/Q7830165","display_name":"Townsend","level":2,"score":0.9359425902366638},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.6465207934379578},{"id":"https://openalex.org/C103790658","wikidata":"https://www.wikidata.org/wiki/Q111180","display_name":"Protoplasm","level":3,"score":0.49904584884643555},{"id":"https://openalex.org/C122637931","wikidata":"https://www.wikidata.org/wiki/Q118084","display_name":"Unit (ring theory)","level":2,"score":0.4423511326313019},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3931015133857727},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3506430685520172},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.2803199887275696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2183762490749359},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21106961369514465},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.19656524062156677},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1265505850315094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09931603074073792},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.06530490517616272},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001192","descriptor_name":"Arylsulfatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002609","descriptor_name":"Chediak-Higashi Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002609","descriptor_name":"Chediak-Higashi Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007085","descriptor_name":"Ilium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/path.1711300405","doi":"https://doi.org/10.1002/path.1711300405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711300405","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:7391859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7391859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1980-2160","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1980/1161","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1980","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W36456650","https://openalex.org/W55200214","https://openalex.org/W56708359","https://openalex.org/W1475713056","https://openalex.org/W1536323386","https://openalex.org/W1537396858","https://openalex.org/W1568177555","https://openalex.org/W1605151088","https://openalex.org/W1982737414","https://openalex.org/W1997959817","https://openalex.org/W2007704417","https://openalex.org/W2012600477","https://openalex.org/W2018668472","https://openalex.org/W2033801664","https://openalex.org/W2068595115","https://openalex.org/W2093617753","https://openalex.org/W2108192721","https://openalex.org/W2109401564","https://openalex.org/W2109476664","https://openalex.org/W2121546449","https://openalex.org/W2125999925","https://openalex.org/W2138948114","https://openalex.org/W2170162094","https://openalex.org/W2211749279","https://openalex.org/W2499025676","https://openalex.org/W2886343980","https://openalex.org/W2988207268"],"related_works":["https://openalex.org/W7095288129","https://openalex.org/W1520160182","https://openalex.org/W1582212744","https://openalex.org/W2170162094","https://openalex.org/W1536323386","https://openalex.org/W2426816172","https://openalex.org/W1982865150","https://openalex.org/W2912659038","https://openalex.org/W2055056979","https://openalex.org/W2088732407"],"abstract_inverted_index":{"The":[0,14,33,53,151],"beige":[1,51,69,124,156],"mouse":[2,103,157],"(bg/bg)":[3],"is":[4,16,81],"an":[5],"analogue":[6],"of":[7,21,50,68,91,137,154,171,173],"the":[8,19,85,155,169,174],"Chediak-Higashi":[9],"syndrome":[10],"(CHS)":[11],"in":[12,29,46,48,66,100,166],"man.":[13],"disorder":[15],"characterised":[17],"by":[18,89],"presence":[20],"enlarged":[22],"cytoplasmic":[23,164],"granules,":[24],"said":[25],"to":[26,77,130],"be":[27],"lysosomes,":[28],"many":[30],"cell":[31,170],"types.":[32],"present":[34,65],"report":[35],"describes":[36],"giant":[37,54,86,95,138,152],"lysosomes":[38,41,55,87,96,139,153],"defined":[39],"as":[40,163],"greater":[42],"than":[43],"1.0":[44],"micrometers":[45],"diameter,":[47],"osteoclasts":[49,67,101,122,143],"mice.":[52],"contained":[56],"both":[57],"acid":[58],"phosphatase":[59],"and":[60,63,147],"aryl":[61],"sulphatase":[62],"were":[64,97],"mice":[70,125,146],"aged":[71,126],"from":[72,102,107,123,127,144],"at":[73],"least":[74],"4":[75,128],"days":[76,129],"3":[78,131],"months.":[79],"There":[80],"some":[82],"evidence":[83],"that":[84,121],"form":[88],"fusion":[90],"smaller":[92],"structures.":[93],"Since":[94],"also":[98],"seen":[99],"strains":[104],"not":[105],"suffering":[106],"CHS,":[108],"e.g.,":[109],"CBA":[110,145],"mice,":[111],"a":[112],"quantitative":[113],"survey":[114],"was":[115,119],"carried":[116],"out.":[117],"It":[118],"shown":[120],"months":[132],"contain":[133],"significantly":[134],"increased":[135],"numbers":[136],"when":[140],"compared":[141],"with":[142],"CBAXbg/bg":[148],"F1":[149],"hybrids.":[150],"osteoclast":[158],"are":[159],"currently":[160],"being":[161],"used":[162],"markers":[165],"experiments":[167],"on":[168],"origin":[172],"osteoclast.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}