{"id":"https://openalex.org/W2059904995","doi":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","title":"NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A","display_name":"NEW HERITABLE FRAGILE SITE ON CHROMOSOME 8 INDUCED BY DISTAMYCIN A","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W2059904995","doi":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","mag":"2059904995","pmid":"https://pubmed.ncbi.nlm.nih.gov/3130346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5917470"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.1988.tb01568.x","doi":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5917470","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108636624","display_name":"Hisako Ochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Ochi","raw_affiliation_strings":["Epidemiology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110403018","display_name":"Shaw Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shaw Watanabe","raw_affiliation_strings":["Epidemiology Division, National Cancer Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Division, National Cancer Center Research Institute","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027582885","display_name":"Hiroshi Yamamoto","orcid":"https://orcid.org/0000-0003-3865-8708","observed_orcids":["https://orcid.org/0000-0003-3865-8708"]},"institutions":[{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yamamoto","raw_affiliation_strings":["Surgery Division, National Cancer Center Hospital, Tsukiji 5\u20101\u20101, Chuo\u2010ku, Tokyo 104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Division, National Cancer Center Hospital, Tsukiji 5\u20101\u20101, Chuo\u2010ku, Tokyo 104","institution_ids":["https://openalex.org/I4405285273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3627,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57082968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"2","first_page":"145","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/distamycin-a","display_name":"distamycin A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mastopathy","display_name":"mastopathy","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C60449816","wikidata":"https://www.wikidata.org/wiki/Q5113903","display_name":"Chromosomal fragile site","level":4,"score":0.9846556186676025},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.774147629737854},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6953226923942566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6144531965255737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6006782054901123},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5357450842857361},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.43483251333236694},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37352025508880615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20719322562217712}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002873","descriptor_name":"Chromosome Fragility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004214","descriptor_name":"Distamycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043283","descriptor_name":"Chromosome Fragile Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.1988.tb01568.x","doi":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1988.tb01568.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4862267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5917470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5917470","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5917470","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jpn J Cancer Res","raw_type":"Text"},{"id":"pmid:3130346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3130346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4862267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5917470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1606947195","https://openalex.org/W1999577909","https://openalex.org/W2032748338","https://openalex.org/W2046765308","https://openalex.org/W2062698287","https://openalex.org/W2080769616","https://openalex.org/W2085837106","https://openalex.org/W2092299362","https://openalex.org/W2092441446","https://openalex.org/W2100133988"],"related_works":["https://openalex.org/W2085837106","https://openalex.org/W2097887197","https://openalex.org/W2110191432","https://openalex.org/W2886593988","https://openalex.org/W2082372219","https://openalex.org/W1989775270","https://openalex.org/W2080769616","https://openalex.org/W7065447828","https://openalex.org/W2079625027","https://openalex.org/W4234409452"],"abstract_inverted_index":{"A":[0,41],"possible":[1],"new":[2,90],"heritable":[3,91],"fragile":[4,35,82,92],"site":[5,36,72,93],"at":[6,69],"band":[7,84],"8q24.1,":[8],"which":[9],"is":[10,85],"known":[11],"to":[12,87],"be":[13,88],"a":[14,30,89],"breakpoint":[15],"in":[16,26,49,76],"various":[17],"cancers":[18],"and":[19,43,47],"contains":[20],"the":[21,27,52,70,79],"c-myc":[22],"locus,":[23],"was":[24,37],"found":[25],"lymphocytes":[28,56],"from":[29,57],"woman":[31],"with":[32],"mastopathy.":[33],"This":[34,81],"induced":[38,94],"by":[39,95],"distamycin":[40,96],"treatment,":[42],"expressed":[44],"as":[45],"gaps":[46,66],"breaks":[48,68],"18%":[50],"of":[51,59,73,78],"metaphases":[53],"examined.":[54],"The":[55],"one":[58],"her":[60],"two":[61],"sons":[62],"examined":[63],"also":[64],"revealed":[65],"or":[67],"same":[71],"chromosome":[74],"8":[75],"34%":[77],"metaphases.":[80],"8q24.1":[83],"considered":[86],"A.":[97]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
