{"id":"https://openalex.org/W2059822157","doi":"https://doi.org/10.1021/jp970990j","title":"Thermodynamic Study of the Effects of Ursodeoxycholic Acid and Ursodeoxycholate on Aqueous Dipalmitoyl Phosphatidylcholine Bilayer Dispersions","display_name":"Thermodynamic Study of the Effects of Ursodeoxycholic Acid and Ursodeoxycholate on Aqueous Dipalmitoyl Phosphatidylcholine Bilayer Dispersions","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2059822157","doi":"https://doi.org/10.1021/jp970990j","mag":"2059822157"},"language":"en","primary_location":{"id":"doi:10.1021/jp970990j","doi":"https://doi.org/10.1021/jp970990j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp970990j","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066224974","display_name":"Maria Tomoaia-Coti\u015fel","orcid":"https://orcid.org/0000-0002-0995-3006","observed_orcids":["https://orcid.org/0000-0002-0995-3006"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Tomoaia-Cotisel","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111569185","display_name":"Ira W. Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira W. Levin","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2355,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.50113502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"101","issue":"42","first_page":"8477","last_page":"8485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10306","display_name":"Liquid Crystal Research Advancements","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dipalmitoylphosphatidylcholine","display_name":"DPPC","score":0.9350000023841858},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.6869999766349792},{"id":"https://openalex.org/keywords/thermotropic-phase-behavior","display_name":"thermotropic phase behavior","score":0.7649999856948853},{"id":"https://openalex.org/keywords/gel-to-liquid-crystalline-phase-transition","display_name":"gel to liquid-crystalline phase transition","score":0.8809999823570251},{"id":"https://openalex.org/keywords/phase-transition-enthalpy","display_name":"phase transition enthalpy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gibbs-free-energy","display_name":"Gibbs free energy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/interdigitated-gel-phase","display_name":"interdigitated gel phase","score":0.7749999761581421},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7506011724472046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7255103588104248},{"id":"https://openalex.org/C22064058","wikidata":"https://www.wikidata.org/wiki/Q7783262","display_name":"Thermotropic crystal","level":4,"score":0.6887128353118896},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.5725113153457642},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5449782609939575},{"id":"https://openalex.org/C149288129","wikidata":"https://www.wikidata.org/wiki/Q185357","display_name":"Phase transition","level":2,"score":0.5336264967918396},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.5161989331245422},{"id":"https://openalex.org/C202270520","wikidata":"https://www.wikidata.org/wiki/Q634314","display_name":"Calorimetry","level":2,"score":0.5156437158584595},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.5014293193817139},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.49194666743278503},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4065793752670288},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.36914098262786865},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.35791659355163574},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2885738015174866},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.2831824719905853},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.16165855526924133},{"id":"https://openalex.org/C2994273327","wikidata":"https://www.wikidata.org/wiki/Q203989","display_name":"Liquid crystalline","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jp970990j","doi":"https://doi.org/10.1021/jp970990j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp970990j","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1530643833","https://openalex.org/W1580235173","https://openalex.org/W1965370196","https://openalex.org/W1966052689","https://openalex.org/W1980863338","https://openalex.org/W1981477160","https://openalex.org/W1983306302","https://openalex.org/W1987036606","https://openalex.org/W1990150511","https://openalex.org/W1991665912","https://openalex.org/W1992443702","https://openalex.org/W1997185569","https://openalex.org/W2002590932","https://openalex.org/W2003806540","https://openalex.org/W2006213598","https://openalex.org/W2010340554","https://openalex.org/W2011108870","https://openalex.org/W2024902809","https://openalex.org/W2025811739","https://openalex.org/W2033528416","https://openalex.org/W2041640139","https://openalex.org/W2041785632","https://openalex.org/W2047922666","https://openalex.org/W2060059515","https://openalex.org/W2061763156","https://openalex.org/W2067405676","https://openalex.org/W2070315057","https://openalex.org/W2079058730","https://openalex.org/W2084543459","https://openalex.org/W2086522192","https://openalex.org/W2091084349","https://openalex.org/W2095277264","https://openalex.org/W2149483752","https://openalex.org/W2161794211","https://openalex.org/W2326791472","https://openalex.org/W2468934355"],"related_works":["https://openalex.org/W1514012786","https://openalex.org/W1522632074","https://openalex.org/W2034249498","https://openalex.org/W2048392563","https://openalex.org/W2054206183","https://openalex.org/W2065658424","https://openalex.org/W2061595163","https://openalex.org/W2024228122","https://openalex.org/W2575201556","https://openalex.org/W2054464783"],"abstract_inverted_index":{"The":[0,53,86,102,175,216],"effects":[1],"of":[2,16,20,38,77,95,110,114,120,134,151,167,201,235,242],"ursodeoxycholic":[3],"acid":[4],"(UDCAH)":[5],"and":[6,40,116,119,127,258],"ursodeoxycholate":[7],"(UDCA":[8],"-":[9,42,118],")":[10,208],"on":[11],"the":[12,63,75,78,93,98,111,121,132,140,159,168,180,220],"thermotropic":[13],"phase":[14,83,124,141,164,186,209,223,255],"behavior":[15],"aqueous":[17],"bilayer":[18,65,88,123],"dispersions":[19],"1,2-dipalmitoyl-3-":[21],"sn":[22],"-phosphatidylcholine":[23],"(DPPC),":[24],"buffered":[25],"at":[26,97],"pH":[27],"7.0,":[28],"were":[29],"examined":[30],"by":[31,44,211],"differential":[32],"scanning":[33],"calorimetry":[34],"(DSC)":[35],"for":[36,138,149,189],"concentrations":[37,61,100,150,191,241],"UDCAH":[39,115],"UDCA":[41,60,96,117,152,190,243],"(represented":[43],"UDCA)":[45],"from":[46],"0":[47],"to":[48,80,154,161,183,232],"approximately":[49,155,193],"76":[50],"mol":[51,157,195,249],"%.":[52],"calorimetric":[54,103],"data":[55,217],"show":[56],"that":[57,177,219],"progressively":[58],"increasing":[59,74],"decreases":[62],"DPPC":[64,87,122,181,254],"main":[66],"transition":[67,84,125,165,187,256],"temperatures":[68,257],"(":[69],"T":[70],"m":[71],"),":[72],"while":[73],"widths":[76],"gel":[79,160,182,205,222],"liquid":[81,162,184],"crystalline":[82,163,185],"endotherms.":[85],"pretransition":[89],"is":[90,197],"suppressed":[91],"in":[92,108,143,179,199,225,244,252],"presence":[94],"lowest":[99],"employed.":[101],"data,":[104],"which":[105],"are":[106],"interpreted":[107,198],"terms":[109,200],"partition":[112],"equilibria":[113],"enthalpies":[126,166,188],"Gibbs":[128],"free":[129],"energies,":[130],"allow":[131],"development":[133],"a":[135],"thermodynamic":[136],"approach":[137],"determining":[139],"boundaries":[142],"mixed":[144,169],"DPPC:UDCA":[145,170,213],"dispersions.":[146],"In":[147],"particular,":[148],"up":[153],"25":[156],"%,":[158],"bilayers":[171],"remain":[172,231],"essentially":[173],"constant.":[174],"increase":[176],"occurs":[178],"between":[192],"25\u221260":[194],"%":[196,250],"an":[202],"induced":[203],"interdigitated":[204,221],"(L":[206],"gI":[207],"stabilized":[210],"specific":[212],"molecular":[214],"interactions.":[215],"suggest":[218],"exists":[224],"equilibrium":[226],"with":[227],"micelles,":[228],"whose":[229],"structures":[230],"be":[233],"elucidated,":[234],"various":[236],"UDCA:DPPC":[237],"mole":[238],"ratios.":[239],"Finally,":[240],"amounts":[245],"greater":[246],"than":[247],"60":[248],"result":[251],"constant":[253],"enthalpies.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2016-06-24T00:00:00"}