{"id":"https://openalex.org/W2059664120","doi":"https://doi.org/10.1358/dnp.2008.21.6.1246795","title":"Inhibition of PCSK9 as a Novel Strategy for the Treatment of Hypercholesterolemia","display_name":"Inhibition of PCSK9 as a Novel Strategy for the Treatment of Hypercholesterolemia","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2059664120","doi":"https://doi.org/10.1358/dnp.2008.21.6.1246795","mag":"2059664120","pmid":"https://pubmed.ncbi.nlm.nih.gov/18836590"},"language":"en","primary_location":{"id":"doi:10.1358/dnp.2008.21.6.1246795","doi":"https://doi.org/10.1358/dnp.2008.21.6.1246795","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dnp.2008.21.6.1246795","pdf_url":null,"source":{"id":"https://openalex.org/S51538572","display_name":"Drug News & Perspectives","issn_l":"0214-0934","issn":["0214-0934","2013-0139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug News &amp; Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046097404","display_name":"Dayami Lopez","orcid":"https://orcid.org/0000-0001-8643-0447","observed_orcids":["https://orcid.org/0000-0001-8643-0447"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dayami Lopez","raw_affiliation_strings":["Department of Experimental Therapeutics, Moffitt Cancer Center, Tampa, Florida 33612, USA. dayami.lopez@moffitt.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Moffitt Cancer Center, Tampa, Florida 33612, USA. dayami.lopez@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046097404"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":0.7066,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.76567937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"21","issue":"6","first_page":"323","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9-inhibition","display_name":"PCSK9 inhibition","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ldl-receptor-degradation","display_name":"LDL receptor degradation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.42500001192092896},{"id":"https://openalex.org/keywords/hypocholesterolemia","display_name":"hypocholesterolemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pcsk9-mutations","display_name":"PCSK9 mutations","score":0.7770000100135803},{"id":"https://openalex.org/keywords/statin-combination-therapy","display_name":"statin combination therapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/plasma-cholesterol-lowering","display_name":"plasma cholesterol lowering","score":0.640999972820282},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.9831236600875854},{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.9192113876342773},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.8464758992195129},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.781208872795105},{"id":"https://openalex.org/C2778978578","wikidata":"https://www.wikidata.org/wiki/Q10295810","display_name":"Hypocholesterolemia","level":3,"score":0.7609878182411194},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5847028493881226},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5668017268180847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5641594529151917},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.5597584843635559},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.447884738445282},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4368184208869934},{"id":"https://openalex.org/C2779811187","wikidata":"https://www.wikidata.org/wiki/Q423655","display_name":"Subtilisin","level":3,"score":0.43564993143081665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43456369638442993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42443180084228516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18273794651031494},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15399393439292908}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1358/dnp.2008.21.6.1246795","doi":"https://doi.org/10.1358/dnp.2008.21.6.1246795","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dnp.2008.21.6.1246795","pdf_url":null,"source":{"id":"https://openalex.org/S51538572","display_name":"Drug News & Perspectives","issn_l":"0214-0934","issn":["0214-0934","2013-0139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug News &amp; Perspectives","raw_type":"journal-article"},{"id":"pmid:18836590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18836590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug news & perspectives","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W73177875","https://openalex.org/W2138544596","https://openalex.org/W206929045","https://openalex.org/W2012570825","https://openalex.org/W2746101947","https://openalex.org/W2017509882","https://openalex.org/W1976252526","https://openalex.org/W2110619762","https://openalex.org/W2141191772","https://openalex.org/W1888435097"],"abstract_inverted_index":{"Proprotein":[0],"convertase":[1],"subtilisin/kexin":[2],"type":[3],"9":[4],"(PCSK9)":[5],"plays":[6],"a":[7,93],"critical":[8],"role":[9],"controlling":[10],"the":[11,21,29,56,62,90],"levels":[12,72,117],"of":[13,55,65,78,85,92],"low-density":[14],"lipoprotein":[15],"(LDL)":[16],"particles":[17],"that":[18,48],"circulate":[19],"in":[20,28,61,67,96,121],"bloodstream.":[22],"Several":[23],"gain-of-function":[24],"and":[25,38,42,81],"loss-of-function":[26],"mutations":[27],"PCSK9":[30,49,66,95],"gene,":[31],"which":[32],"occur":[33],"naturally,":[34],"have":[35,46],"been":[36],"identified":[37],"linked":[39],"to":[40],"hypercholesterolemia":[41],"hypocholesterolemia,":[43],"respectively.":[44],"Studies":[45],"demonstrated":[47],"acts":[50],"mainly":[51],"by":[52,74],"enhancing":[53],"degradation":[54],"LDL":[57,87,115],"receptor":[58],"(LDLR)":[59],"protein":[60,80],"liver.":[63],"Inactivation":[64],"mice":[68],"reduces":[69],"plasma":[70,114],"cholesterol":[71,116],"primarily":[73],"increasing":[75],"hepatic":[76],"expression":[77],"LDLR":[79],"thereby":[82],"accelerating":[83],"clearance":[84],"circulating":[86],"cholesterol.":[88],"Since":[89],"loss":[91],"functional":[94],"human":[97],"is":[98,107],"not":[99],"associated":[100],"with":[101,123],"apparent":[102],"deleterious":[103],"effects,":[104],"this":[105],"protease":[106],"becoming":[108],"an":[109],"attractive":[110],"target":[111],"for":[112],"lowering":[113],"either":[118],"alone":[119],"or":[120],"combination":[122],"statins.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
