{"id":"https://openalex.org/W2059639666","doi":"https://doi.org/10.1136/bjo.56.10.770","title":"Topical propranolol and ocular tension in the human.","display_name":"Topical propranolol and ocular tension in the human.","publication_year":1972,"publication_date":"1972-10-01","ids":{"openalex":"https://openalex.org/W2059639666","doi":"https://doi.org/10.1136/bjo.56.10.770","mag":"2059639666","pmid":"https://pubmed.ncbi.nlm.nih.gov/4607298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1214714"},"language":"en","primary_location":{"id":"doi:10.1136/bjo.56.10.770","doi":"https://doi.org/10.1136/bjo.56.10.770","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.56.10.770","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/56/10/770.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjo.bmj.com/content/bjophthalmol/56/10/770.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054102274","display_name":"Janet Vale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159425","display_name":"Princess Alexandra Eye Pavilion","ror":"https://ror.org/00jz7d133","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801159425"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Vale","raw_affiliation_strings":["From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA","institution_ids":["https://openalex.org/I2801159425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057213428","display_name":"Alan C. Gibbs","orcid":"https://orcid.org/0000-0002-4305-6755","observed_orcids":["https://orcid.org/0000-0002-4305-6755"]},"institutions":[{"id":"https://openalex.org/I2801159425","display_name":"Princess Alexandra Eye Pavilion","ror":"https://ror.org/00jz7d133","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801159425"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A C Gibbs","raw_affiliation_strings":["From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA","institution_ids":["https://openalex.org/I2801159425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113530337","display_name":"Calbert I. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159425","display_name":"Princess Alexandra Eye Pavilion","ror":"https://ror.org/00jz7d133","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801159425"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C I Phillips","raw_affiliation_strings":["Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Manchester, Oxford Road, Manchester M13 gPL","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"From the Departments of Pharmacology, Social and Preventive Medicine, and Ophthalmology, University of Manchester","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Princes, Alexandra Eye Pavilion, Chalmers St., Ediniburgh, EH3 gHA","institution_ids":["https://openalex.org/I2801159425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8582,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93917275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"10","first_page":"770","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9089999794960022},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.953000009059906},{"id":"https://openalex.org/keywords/open-angle-glaucoma","display_name":"open-angle glaucoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glaucoma-treatment","display_name":"glaucoma treatment","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8939807415008545},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.797339916229248},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5215696692466736},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.5147695541381836},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.17608779668807983}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/bjo.56.10.770","doi":"https://doi.org/10.1136/bjo.56.10.770","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.56.10.770","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/56/10/770.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:4607298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4607298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:1214714","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1214714/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Ophthalmol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/bjo.56.10.770","doi":"https://doi.org/10.1136/bjo.56.10.770","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.56.10.770","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/56/10/770.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059639666.pdf","grobid_xml":"https://content.openalex.org/works/W2059639666.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2047758179","https://openalex.org/W2118545984","https://openalex.org/W2178155639","https://openalex.org/W2409654836"],"related_works":["https://openalex.org/W2037273012","https://openalex.org/W2028322387","https://openalex.org/W2056837875","https://openalex.org/W36606618","https://openalex.org/W6990057481","https://openalex.org/W2053505929","https://openalex.org/W2052163742","https://openalex.org/W7163781988","https://openalex.org/W2022585565","https://openalex.org/W2048595013"],"abstract_inverted_index":{"Propranolol":[0],"was":[1,92],"introduced":[2],"as":[3],"a":[4,46],"0-adrenergic":[5],"receptor":[6],"antagonist,":[7],"having":[8],"about":[9],"ten":[10],"times":[11],"the":[12],"potency":[13],"of":[14,28,48],"pronethalol":[15],"against":[16],"isoprenaline":[17],"(Black,":[18],"Crowther,":[19],"Shanks,":[20],"Smith,":[21],"and":[22,39,57,65,74,77,86],"Dornhorst,":[23],"I964)":[24],"while":[25],"being":[26],"devoid":[27],"intrinsic":[29],"sympathomimetic":[30],"activity.A":[31],"preliminary":[32],"investigation":[33],"with":[34,53],"systemic":[35],"racemic":[36],"propranolol":[37,71,83,91],"intravenously":[38,81],"by":[40,63,75],"mouth":[41],"showed":[42],"that":[43,89],"it":[44],"caused":[45],"lowering":[47],"ocular":[49],"tension":[50,97],"in":[51,72,84,95],"patients":[52],"glaucoma":[54,103],"(Phillips,":[55],"Howitt,":[56],"Rowlands,":[58],"I967).These":[59],"observations":[60],"were":[61],"confirmed":[62],"Cote":[64],"Drance":[66],"(i968)":[67],"using":[68,80],"orally":[69],"administered":[70,82],"humans,":[73],"Vale":[76],"Phillips":[78],"(I970)":[79],"humans":[85],"rabbits.Following":[87],"reports":[88],"topical":[90],"also":[93],"effective":[94],"reducing":[96],"(Bucci,":[98],"J":[99],"F":[100],"82Bilateral":[101],"open-angle":[102],"None":[104]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
