{"id":"https://openalex.org/W2059638779","doi":"https://doi.org/10.4149/neo_2012_022","title":"Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia","display_name":"Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia","publication_year":2011,"publication_date":"2011-12-09","ids":{"openalex":"https://openalex.org/W2059638779","doi":"https://doi.org/10.4149/neo_2012_022","mag":"2059638779","pmid":"https://pubmed.ncbi.nlm.nih.gov/22248274"},"language":"en","primary_location":{"id":"doi:10.4149/neo_2012_022","doi":"https://doi.org/10.4149/neo_2012_022","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2012_022","pdf_url":"http://www.elis.sk/download_file.php?product_id=2554&session_id=je9gif980p1d6akuliii0s6803","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.elis.sk/download_file.php?product_id=2554&session_id=je9gif980p1d6akuliii0s6803","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065759166","display_name":"Hana Cechova","orcid":"https://orcid.org/0000-0003-0539-8575","observed_orcids":["https://orcid.org/0000-0003-0539-8575"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"H. CECHOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, Prague, Czech Republic. hana.cechova@uhkt.cz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, Prague, Czech Republic. hana.cechova@uhkt.cz","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047269523","display_name":"Petra La\u0161\u0161uthov\u00e1","orcid":"https://orcid.org/0000-0003-1726-5868","observed_orcids":["https://orcid.org/0000-0003-1726-5868"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"P. LASSUTHOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005424543","display_name":"Ludmila Nov\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0003-0564-0376","observed_orcids":["https://orcid.org/0000-0003-0564-0376"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"L. NOVAKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058574596","display_name":"Monika Beli\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-9158-881X","observed_orcids":["https://orcid.org/0000-0002-9158-881X"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"M. BELICKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062215070","display_name":"R. Stemberkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"R. STEMBERKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091222108","display_name":"J\u00e1n Jen\u010d\u00edk","orcid":"https://orcid.org/0000-0001-8743-0019","observed_orcids":["https://orcid.org/0000-0001-8743-0019"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J. JENCIK","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. STANKOVA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"M. STANKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025863196","display_name":"Pavla Hrabakova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"P. HRABAKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037757643","display_name":"Kristyna Pegova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"K. PEGOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. ZIZKOVA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"H. ZIZKOVA","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086626929","display_name":"Jaroslav \u010cerm\u00e1k","orcid":"https://orcid.org/0009-0006-0961-3294","observed_orcids":["https://orcid.org/0009-0006-0961-3294","https://orcid.org/0000-0003-0524-9617"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J. CERMAK","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210096318"],"apc_list":null,"apc_paid":null,"fwci":1.8768,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86456243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"02","first_page":"168","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.34450000524520874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/9p21","display_name":"9p21","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":1.0},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/myelodysplastic-myeloproliferative-neoplasms","display_name":"myelodysplastic/myeloproliferative neoplasms","score":0.9459999799728394},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.8130000233650208},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7210000157356262},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2776300330","wikidata":"https://www.wikidata.org/wiki/Q17860505","display_name":"CDKN2B","level":4,"score":0.9508295059204102},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7803331017494202},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7271601557731628},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6622828245162964},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.6518738269805908},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6119584441184998},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5433228611946106},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4342745542526245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3955664038658142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3863794505596161},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31883716583251953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26407337188720703},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.20585063099861145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19643732905387878},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14243176579475403}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4149/neo_2012_022","doi":"https://doi.org/10.4149/neo_2012_022","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2012_022","pdf_url":"http://www.elis.sk/download_file.php?product_id=2554&session_id=je9gif980p1d6akuliii0s6803","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},{"id":"pmid:22248274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22248274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.4149/neo_2012_022","doi":"https://doi.org/10.4149/neo_2012_022","is_oa":true,"landing_page_url":"https://doi.org/10.4149/neo_2012_022","pdf_url":"http://www.elis.sk/download_file.php?product_id=2554&session_id=je9gif980p1d6akuliii0s6803","source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059638779.pdf","grobid_xml":"https://content.openalex.org/works/W2059638779.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W180279674","https://openalex.org/W1516326873","https://openalex.org/W1661110056","https://openalex.org/W1966010937","https://openalex.org/W1969433126","https://openalex.org/W1977706798","https://openalex.org/W1994465394","https://openalex.org/W1995643652","https://openalex.org/W1996919750","https://openalex.org/W2008731424","https://openalex.org/W2056711391","https://openalex.org/W2060228790","https://openalex.org/W2060311019","https://openalex.org/W2081584971","https://openalex.org/W2086492419","https://openalex.org/W2086858024","https://openalex.org/W2088633051","https://openalex.org/W2089548634","https://openalex.org/W2094003121","https://openalex.org/W2104304026","https://openalex.org/W2107398329","https://openalex.org/W2118094114","https://openalex.org/W2118771330","https://openalex.org/W2127240439","https://openalex.org/W2165518576","https://openalex.org/W2168473428","https://openalex.org/W2171676482","https://openalex.org/W2354344320","https://openalex.org/W4211114385","https://openalex.org/W4393339805"],"related_works":["https://openalex.org/W2554275421","https://openalex.org/W2521977451","https://openalex.org/W2980075754","https://openalex.org/W2127240439","https://openalex.org/W2020442879","https://openalex.org/W2182971183","https://openalex.org/W2751747058","https://openalex.org/W2979700576","https://openalex.org/W2887189501","https://openalex.org/W2079906801"],"abstract_inverted_index":{"Epigenetic":[0],"de":[1],"novo":[2],"methylation":[3,33,90,115,139,170,196,216,226],"of":[4,34,106,114,121,179,195,212,228,237,247,256],"CpG":[5],"islands":[6],"is":[7],"an":[8,137,250],"important":[9,251],"event":[10,252],"in":[11,39,70,93,97,100,104,109,118,126,131,169,181,197,204,240,253],"malignant":[12],"transformation.":[13],"Two":[14],"genes":[15,36],"are":[16],"frequently":[17],"methylated:":[18],"cyclin-dependent":[19,25],"kinase":[20,26],"inhibitor":[21,27],"2B":[22],"(CDKN2B)":[23],"and":[24,51,99,129,160,176,207],"2A":[28],"(CDKN2A).":[29],"In":[30,134],"our":[31],"study":[32,243],"these":[35],"was":[37,85,91,116,140,202,217],"studied":[38],"63":[40],"patients":[41,59,108,123,198],"with":[42,47,53,81,142,200,209,219],"myelodysplastic":[43],"syndromes":[44],"(MDS),":[45],"2":[46],"myelodysplastic/myeloproliferative":[48],"neoplasms":[49],"(MDS/MPN)":[50],"13":[52],"acute":[54],"myeloid":[55],"leukemia":[56],"(AML).":[57],"Five":[58],"were":[60,68,172],"monitored":[61],"during":[62],"5-azacytidine":[63],"treatment.":[64],"Twenty-six":[65],"healthy":[66],"donors":[67],"tested":[69],"a":[71,143,235],"control":[72],"group.":[73,111],"Methylation-specific":[74],"multiplex":[75],"ligation-dependent":[76],"probe":[77],"amplification":[78],"(MS-MLPA)":[79],"method":[80],"all":[82],"associated":[83,141],"techniques":[84],"used":[86,233],"for":[87,190],"detection.":[88],"Aberrant":[89],"present":[92],"the":[94,101,107,119,154,161,210,213,225,245,254],"CDKN2A":[95,127,191],"gene":[96,103,128,183,206,230],"38%":[98],"CDKN2B":[102,132,182,205,229],"77%":[105,125],"MDS":[110,135,180,257],"The":[112,193],"level":[113,171,227],"higher":[117],"group":[120],"AML":[122],"-":[124],"100%":[130],"gene.":[133,192],"patients,":[136],"aberrant":[138],"tendency":[144],"to":[145,153,258],"disease":[146,220],"progression":[147,255],"towards":[148],"more":[149],"advanced":[150,177],"forms":[151,178],"according":[152],"World":[155],"Health":[156],"Organization":[157],"(WHO)":[158],"classification":[159],"International":[162],"Prognostic":[163],"Scoring":[164],"System":[165],"(IPSS).":[166],"Significant":[167],"differences":[168],"observed":[173],"between":[174],"early":[175],"(P":[184],"value":[185],"<":[186],"0.05)":[187],"but":[188],"not":[189],"trend":[194],"treated":[199],"azacitidine":[201],"analyzed":[203],"correlated":[208],"course":[211],"disease.":[214],"Increased":[215],"connected":[218],"progression.":[221],"We":[222],"concluded":[223],"that":[224],"might":[231],"be":[232],"as":[234,249],"marker":[236],"leukemic":[238],"transformation":[239],"MDS.":[241],"Our":[242],"indicates":[244],"role":[246],"hypermethylation":[248],"AML.":[259]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}