{"id":"https://openalex.org/W2059635169","doi":"https://doi.org/10.1086/677360","title":"Safety and Efficacy of Transition from Inhaled Treprostinil to Parenteral Treprostinil in Selected Patients with Pulmonary Arterial Hypertension","display_name":"Safety and Efficacy of Transition from Inhaled Treprostinil to Parenteral Treprostinil in Selected Patients with Pulmonary Arterial Hypertension","publication_year":2014,"publication_date":"2014-08-12","ids":{"openalex":"https://openalex.org/W2059635169","doi":"https://doi.org/10.1086/677360","mag":"2059635169","pmid":"https://pubmed.ncbi.nlm.nih.gov/25621159","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4278605"},"language":"en","primary_location":{"id":"doi:10.1086/677360","doi":"https://doi.org/10.1086/677360","is_oa":true,"landing_page_url":"https://doi.org/10.1086/677360","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/677360","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/677360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010237095","display_name":"Ioana R. Preston","orcid":"https://orcid.org/0000-0002-1378-7362","observed_orcids":["https://orcid.org/0000-0002-1378-7362"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ioana R. Preston","raw_affiliation_strings":["Tufts Medical Center, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medical Center, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110352020","display_name":"Jeremy Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325481341","display_name":"St. Joseph's Hospital and Medical Center","ror":"https://ror.org/00m72wv30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Feldman","raw_affiliation_strings":["St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1325481341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014871838","display_name":"James White","orcid":"https://orcid.org/0000-0001-8371-8453","observed_orcids":["https://orcid.org/0000-0001-8371-8453"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James White","raw_affiliation_strings":["University of Rochester Medical Center, Rochester, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, New York, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016985321","display_name":"Ver\u00f3nica Franco","orcid":"https://orcid.org/0000-0002-1385-2742","observed_orcids":["https://orcid.org/0000-0002-1385-2742"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Franco","raw_affiliation_strings":["Ohio State University, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001771048","display_name":"David C. Ishizawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Ishizawar","raw_affiliation_strings":["University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021429186","display_name":"Charles D. Burger","orcid":"https://orcid.org/0000-0002-4815-3669","observed_orcids":["https://orcid.org/0000-0002-4815-3669"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Burger","raw_affiliation_strings":["Mayo Clinic, Jacksonville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, Florida, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021150751","display_name":"Aaron B. Waxman","orcid":"https://orcid.org/0000-0001-7797-0361","observed_orcids":["https://orcid.org/0000-0001-7797-0361"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron B. Waxman","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067984012","display_name":"Nicholas S. Hill","orcid":"https://orcid.org/0000-0002-8242-8339","observed_orcids":["https://orcid.org/0000-0002-8242-8339"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas S. Hill","raw_affiliation_strings":["Tufts Medical Center, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medical Center, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5010237095"],"corresponding_institution_ids":["https://openalex.org/I1290900354"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":null,"fwci":0.7268,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75029839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"456","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treprostinil","display_name":"treprostinil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inhaled-prostacyclin","display_name":"inhaled prostacyclin","score":0.7319999933242798},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.4410000145435333},{"id":"https://openalex.org/keywords/clinical-deterioration","display_name":"clinical deterioration","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.5329999923706055},{"id":"https://openalex.org/keywords/functional-class","display_name":"functional class","score":0.7170000076293945},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2776432619","wikidata":"https://www.wikidata.org/wiki/Q3495231","display_name":"Treprostinil","level":3,"score":0.997428297996521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9549267888069153},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5118109583854675},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.480155885219574},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.4548535645008087},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35761046409606934},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34586435556411743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21973785758018494}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1086/677360","doi":"https://doi.org/10.1086/677360","is_oa":true,"landing_page_url":"https://doi.org/10.1086/677360","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/677360","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4278605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4278605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulm Circ","raw_type":"Text"},{"id":"pmid:25621159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25621159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1086/677360","doi":"https://doi.org/10.1086/677360","is_oa":true,"landing_page_url":"https://doi.org/10.1086/677360","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/677360","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309555","display_name":"United Therapeutics Corporation","ror":"https://ror.org/03wgxjb31"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059635169.pdf","grobid_xml":"https://content.openalex.org/works/W2059635169.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1969706858","https://openalex.org/W1984693219","https://openalex.org/W2034348825","https://openalex.org/W2055295362","https://openalex.org/W2055506823","https://openalex.org/W2096223780","https://openalex.org/W2096352797","https://openalex.org/W2096751910","https://openalex.org/W2116673293","https://openalex.org/W2168080476","https://openalex.org/W2321461192"],"related_works":["https://openalex.org/W2055506823","https://openalex.org/W2023330853","https://openalex.org/W1974395787","https://openalex.org/W1987735450","https://openalex.org/W2485658572","https://openalex.org/W2485851135","https://openalex.org/W1788443129","https://openalex.org/W2262036130","https://openalex.org/W2179718636","https://openalex.org/W2116673293"],"abstract_inverted_index":{"Guidelines":[0],"for":[1,13,114,197],"the":[2,149,159,240],"treatment":[3,152],"of":[4,72,120,175,191,234],"pulmonary":[5,84],"arterial":[6],"hypertension":[7,85],"(PAH)":[8],"recommend":[9],"sequential":[10],"add-on":[11],"therapy":[12,161],"patients":[14,29,45,73,82,104,204,220,243],"who":[15,49],"deteriorate":[16],"or":[17,90,109,136,171,246],"fail":[18],"to":[19,37,42,52,78,96,164,214,228],"improve":[20,245],"clinically.":[21],"However,":[22],"it":[23],"is":[24],"not":[25],"known":[26],"whether":[27],"these":[28],"also":[30,106],"benefit":[31],"from":[32,34,75,93,225],"transitioning":[33],"inhaled":[35,47,76,94,151,160,176,226],"prostacyclins":[36],"parenteral":[38,53,79,97,179,229],"prostacyclins.":[39],"We":[40,55],"sought":[41],"characterize":[43],"PAH":[44,63,219],"receiving":[46],"treprostinil":[48,77,95,98,227,230],"were":[50,105,116,195],"transitioned":[51,74,92,224],"treprostinil.":[54,80],"conducted":[56],"a":[57,232],"multicenter":[58],"retrospective":[59],"study":[60],"at":[61,153,247],"7":[62],"centers":[64],"and":[65,70,123,127,140,211],"collected":[66],"reasons,":[67],"methods,":[68],"safety,":[69],"outcome":[71],"Twenty-six":[81],"with":[83,172,178,239],"in":[86,133,236],"group":[87],"1,":[88],"4,":[89],"5":[91],"(10":[99],"intravenous,":[100],"16":[101],"subcutaneous).":[102],"Twenty-four":[103],"on":[107],"one":[108],"two":[110],"oral":[111],"therapies.":[112],"Reasons":[113],"transition":[115,184],"clinical":[117,121],"deterioration,":[118],"lack":[119],"improvement,":[122],"pregnancy":[124],"(19,":[125],"6,":[126],"1":[128,212],"patients,":[129,142],"respectively).":[130,143],"Transitions":[131],"occurred":[132],"hospital,":[134],"clinic,":[135],"home":[137],"(17,":[138],"7,":[139],"2":[141],"Parenteral":[144],"infusion":[145],"was":[146,162,185],"started":[147],"after":[148,158],"last":[150],"maintenance":[154],"dose":[155],"(13":[156],"patients),":[157,170],"downtitrated":[163],"18":[165],"[Formula:":[166],"see":[167],"text]g":[168],"(6":[169],"an":[173],"overlap":[174],"downtitration":[177],"uptitration":[180],"(7":[181],"patients).":[182],"The":[183],"safe;":[186],"side":[187],"effects":[188],"included":[189],"symptoms":[190],"prostacyclin":[192],"overdose.":[193],"Patients":[194],"followed":[196],"3-18":[198],"months.":[199],"At":[200],"3":[201],"months,":[202],"8":[203],"improved,":[205],"17":[206],"maintained":[207],"their":[208],"functional":[209],"class,":[210],"continued":[213],"deteriorate.":[215],"In":[216],"conclusion,":[217],"selected":[218],"can":[221],"be":[222],"safely":[223],"using":[231],"variety":[233],"methodologies":[235],"different":[237],"settings":[238],"expectation":[241],"that":[242],"will":[244],"least":[248],"remain":[249],"clinically":[250],"stable.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
