{"id":"https://openalex.org/W2059634693","doi":"https://doi.org/10.1159/000354477","title":"Reciprocal Interferences of TNF-\u03b1 and Wnt1/\u03b2-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure","display_name":"Reciprocal Interferences of TNF-\u03b1 and Wnt1/\u03b2-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2059634693","doi":"https://doi.org/10.1159/000354477","mag":"2059634693","pmid":"https://pubmed.ncbi.nlm.nih.gov/24080828"},"language":"en","primary_location":{"id":"doi:10.1159/000354477","doi":"https://doi.org/10.1159/000354477","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000354477","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1159/000354477","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101409895","display_name":"Yueping Chen","orcid":"https://orcid.org/0000-0003-3860-1568","observed_orcids":["https://orcid.org/0000-0003-3860-1568"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueping Chen","raw_affiliation_strings":["Southern Medical University, 2010 MD TongHe, Guangzhou, China","Southern Medical University, 2010 MD TongHe, Guangzhou,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University, 2010 MD TongHe, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Southern Medical University, 2010 MD TongHe, Guangzhou,","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Chen","raw_affiliation_strings":["Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111853763","display_name":"Qingshui Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099466","display_name":"General Hospital of Guangzhou Military Command","ror":"https://ror.org/00hfbva78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099466"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingshui Yin","raw_affiliation_strings":["Orthopaedic Hospital, People's Liberation Army General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Hospital, People's Liberation Army General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong","institution_ids":["https://openalex.org/I4210099466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016018178","display_name":"Hui Gao","orcid":"https://orcid.org/0000-0002-7306-7471","observed_orcids":["https://orcid.org/0000-0002-7306-7471"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Gao","raw_affiliation_strings":["Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070055463","display_name":"Panfeng Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panfeng Dong","raw_affiliation_strings":["Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452821","display_name":"Xiaoyun Zhang","orcid":"https://orcid.org/0000-0003-2698-7299","observed_orcids":["https://orcid.org/0000-0003-2698-7299"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyun Zhang","raw_affiliation_strings":["Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080247267","display_name":"Jie Kang","orcid":"https://orcid.org/0000-0001-5413-2648","observed_orcids":["https://orcid.org/0000-0001-5413-2648"]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Kang","raw_affiliation_strings":["Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Affiliated Rui Kang Hospital of Guangxi Traditional Chinese Medical School, Nanning 530011, Guangxi Zhuang Autonomous Region,","institution_ids":["https://openalex.org/I4210113348"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":1.4115,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79829579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"32","issue":"3","first_page":"755","last_page":"765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.16539999842643738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ethanol-exposure","display_name":"ethanol exposure","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bios","display_name":"bios","score":0.7200000286102295},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.7840654850006104},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7840380668640137},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.7350724339485168},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.61443692445755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5601847171783447},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5455084443092346},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.47412610054016113},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.47133922576904297},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.46445605158805847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4579748809337616},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.437975138425827},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4194405674934387},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4166710078716278},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.379183292388916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37011513113975525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3194296061992645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17262044548988342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16597360372543335},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05941939353942871},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051155","descriptor_name":"Wnt1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051155","descriptor_name":"Wnt1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051155","descriptor_name":"Wnt1 Protein","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000354477","doi":"https://doi.org/10.1159/000354477","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000354477","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:24080828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24080828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5ca4e0a56a664509a253bfbd42997e94","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ca4e0a56a664509a253bfbd42997e94","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 32, Iss 3, Pp 755-765 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000354477","doi":"https://doi.org/10.1159/000354477","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000354477","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1622028638","https://openalex.org/W1967181926","https://openalex.org/W1967615329","https://openalex.org/W1970728706","https://openalex.org/W1980438612","https://openalex.org/W1981284961","https://openalex.org/W1985147506","https://openalex.org/W1985601827","https://openalex.org/W1994404723","https://openalex.org/W1994596418","https://openalex.org/W2014362480","https://openalex.org/W2020702297","https://openalex.org/W2027821655","https://openalex.org/W2035004863","https://openalex.org/W2048162688","https://openalex.org/W2050171928","https://openalex.org/W2051172891","https://openalex.org/W2059832504","https://openalex.org/W2060235532","https://openalex.org/W2061124209","https://openalex.org/W2064635099","https://openalex.org/W2068659212","https://openalex.org/W2069371353","https://openalex.org/W2073907573","https://openalex.org/W2076732234","https://openalex.org/W2080124218","https://openalex.org/W2086208375","https://openalex.org/W2089426706","https://openalex.org/W2094833579","https://openalex.org/W2106610488","https://openalex.org/W2108778569","https://openalex.org/W2113161490","https://openalex.org/W2118683764","https://openalex.org/W2139652400","https://openalex.org/W2149924247","https://openalex.org/W2153263291","https://openalex.org/W2157644862","https://openalex.org/W2159999899","https://openalex.org/W2169373397","https://openalex.org/W2320444652"],"related_works":["https://openalex.org/W2022282430","https://openalex.org/W2529485442","https://openalex.org/W4366822435","https://openalex.org/W2046954160","https://openalex.org/W7097953599","https://openalex.org/W2888564631","https://openalex.org/W2068659212","https://openalex.org/W2369294995","https://openalex.org/W2069371353","https://openalex.org/W2910842670"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"We":[1,67,79,103,110],"have":[2],"reported":[3],"in":[4,28,52,128,170,212],"a":[5],"separate":[6],"study":[7],"that":[8,51],"alcohol":[9,59,75],"exposure":[10],"triggers":[11],"activation":[12,203,218],"of":[13,23,39,46,82,145,152,161,164,181,198,204,215,219,225,232,241,248,256,261],"the":[14,56,62,136,142,213,254,262],"TNF-\u03b1":[15,40,57,226,263],"signaling":[16,41,64,124,166,206],"pathway":[17],"leading":[18],"to":[19,54,85,135,173,237],"an":[20],"adverse":[21],"shift":[22,247],"multipotential":[24],"mesenchymal":[25],"stem":[26],"cells":[27],"bone":[29],"marrow":[30],"(BMSCs)":[31],"away":[32],"from":[33,71],"osteogenesis":[34,210],"towards":[35,250],"adipogenesis.":[36,47],"However,":[37],"inhibition":[38,45,224],"only":[42],"yielded":[43],"moderate":[44],"Here":[48],"we":[49],"showed":[50],"addition":[53],"promoting":[55,268],"signaling,":[58],"also":[60,111],"suppressed":[61,169],"Wnt1/\u03b2-catenin":[63],"pathway.":[65],"METHODS:":[66],"treated":[68,130],"primary":[69],"BMSCs":[70,129,171,249],"human":[72],"subjects":[73],"with":[74,131,149,239],"for":[76,108,114,267],"24":[77],"days.":[78],"measured":[80],"changes":[81],"genes":[83,184],"related":[84],"endoplasmic":[86],"reticulum":[87],"(ER)":[88],"stress,":[89],"adipogenic":[90,190,234],"markers":[91,94],"and":[92,99,120,187,193,195,223,258,264],"osteogenic":[93,115,132,182],"using":[95],"quantitative":[96],"real-time":[97],"RT-PCR":[98],"Western":[100],"blot":[101],"analysis.":[102],"performed":[104],"Alizarin":[105],"red":[106],"staining":[107],"osteogenesis.":[109,269],"conducted":[112],"assays":[113],"biomarkers":[116],"alkaline":[117],"phosphatase,":[118],"collagen-I":[119],"osteocalcin.":[121],"RESULTS:":[122],"Wnt/\u03b2-catenin":[123,165,205,265],"was":[125,167,176],"markedly":[126],"activated":[127],"inducers":[133],"relative":[134],"control":[137],"cells,":[138],"as":[139,155,157],"indicated":[140],"by":[141,178,207,221,227],"increased":[143,158],"levels":[144,151,160],"nuclear":[146],"\u03b2-catenin":[147],"along":[148],"reduced":[150,196],"cytosolic":[153],"\u03b2-catenin,":[154],"well":[156],"protein":[159],"Wnt1.":[162],"Activation":[163],"significantly":[168],"exposed":[172],"alcohol,":[174],"which":[175],"reflected":[177],"downregulated":[179],"expression":[180],"marker":[183,191],"Osf2/Cbfa1,":[185],"osteopontin":[186],"osteocalcin,":[188],"upregulated":[189],"PPAR\u03b32":[192],"aP2,":[194],"number":[197],"calcifcation":[199],"nodules.":[200],"In":[201],"contrast,":[202],"BIO":[208,222],"favored":[209],"even":[211],"presence":[214],"alcohol.":[216],"Simultaneous":[217],"Wnt1":[220],"3,6'-dithiothalidomide":[228],"produced":[229],"synergetic":[230],"suppression":[231],"ethanol-induced":[233],"lineage":[235,252],"compared":[236],"interference":[238],"either":[240],"them":[242],"alone.":[243],"CONCLUSION:":[244],"This":[245],"remarkable":[246],"osteoblast":[251],"suggests":[253],"superiority":[255],"concordant":[257],"reciprocal":[259],"interferences":[260],"pathways":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}