{"id":"https://openalex.org/W2059634664","doi":"https://doi.org/10.1177/107424849800300206","title":"Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain","display_name":"Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2059634664","doi":"https://doi.org/10.1177/107424849800300206","mag":"2059634664","pmid":"https://pubmed.ncbi.nlm.nih.gov/10684491"},"language":"en","primary_location":{"id":"doi:10.1177/107424849800300206","doi":"https://doi.org/10.1177/107424849800300206","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107424849800300206","pdf_url":null,"source":{"id":"https://openalex.org/S130832228","display_name":"Journal of Cardiovascular Pharmacology and Therapeutics","issn_l":"1074-2484","issn":["1074-2484","1940-4034"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058111361","display_name":"Gilbert R. Upchurch","orcid":"https://orcid.org/0000-0002-4679-8623","observed_orcids":["https://orcid.org/0000-0002-4679-8623"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert R. Upchurch","raw_affiliation_strings":["Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine, Department of Surgery, Brigham and Women 's Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine, Department of Surgery, Brigham and Women 's Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061025856","display_name":"Jane A. Leopold","orcid":"https://orcid.org/0000-0003-0598-8882","observed_orcids":["https://orcid.org/0000-0003-0598-8882"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane A. Leopold","raw_affiliation_strings":["Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031931286","display_name":"George N. Welch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George N. Welch","raw_affiliation_strings":["Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028396638","display_name":"Joseph Loscalzo","orcid":"https://orcid.org/0000-0002-1153-8047","observed_orcids":["https://orcid.org/0000-0002-1153-8047"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Loscalzo","raw_affiliation_strings":["Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Instittete and Evans Department of Medicine, Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1325,"currency":"USD","value_usd":1325},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.18958051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"2","first_page":"135","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyclic-stretch","display_name":"cyclic strain","score":0.8930000066757202},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.875},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.5820000171661377},{"id":"https://openalex.org/keywords/s-nitrosothiols","display_name":"S-nitrosothiols","score":0.8870000243186951},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.6919999718666077},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.47200000286102295},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7813788652420044},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6284646391868591},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6194280982017517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.593987226486206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5222476124763489},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5214375853538513},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5118993520736694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47666600346565247},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4734216332435608},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.46923214197158813},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.42002660036087036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3512246012687683},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3202582001686096},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20020654797554016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16643419861793518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15544521808624268},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1020520031452179},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08971920609474182}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/107424849800300206","doi":"https://doi.org/10.1177/107424849800300206","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107424849800300206","pdf_url":null,"source":{"id":"https://openalex.org/S130832228","display_name":"Journal of Cardiovascular Pharmacology and Therapeutics","issn_l":"1074-2484","issn":["1074-2484","1940-4034"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:10684491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10684491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W10965608","https://openalex.org/W69488511","https://openalex.org/W1545343336","https://openalex.org/W1965588557","https://openalex.org/W1978099891","https://openalex.org/W1978697700","https://openalex.org/W1986733870","https://openalex.org/W1993953283","https://openalex.org/W2002192155","https://openalex.org/W2004829388","https://openalex.org/W2006504630","https://openalex.org/W2025185754","https://openalex.org/W2044918962","https://openalex.org/W2051864488","https://openalex.org/W2059379142","https://openalex.org/W2082494120","https://openalex.org/W2092145002","https://openalex.org/W2092643965","https://openalex.org/W2104238956","https://openalex.org/W2135189810","https://openalex.org/W2143873872","https://openalex.org/W2157603347","https://openalex.org/W2158592093","https://openalex.org/W2169182236","https://openalex.org/W2344300526","https://openalex.org/W2409629223","https://openalex.org/W2412793515","https://openalex.org/W2414258520","https://openalex.org/W2414392119","https://openalex.org/W2418286379","https://openalex.org/W2506095365","https://openalex.org/W4230675525","https://openalex.org/W4285719527","https://openalex.org/W4300643482"],"related_works":["https://openalex.org/W2158592093","https://openalex.org/W7098115900","https://openalex.org/W2506095365","https://openalex.org/W2950430463","https://openalex.org/W2507124899","https://openalex.org/W2106971003","https://openalex.org/W2757655070","https://openalex.org/W2019717794","https://openalex.org/W2152724821","https://openalex.org/W2064282645"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nitric":[1],"oxide":[2],"(NO),":[3],"a":[4,143,187],"potent":[5],"vasodilator":[6],"and":[7,67,95,126,130,151,172,202,229,273,285,293,304],"inhibitor":[8],"of":[9,21,46,61,73,87,97,145,163,179,249,260,283,290,358,365,374],"platelet":[10],"function,":[11],"is":[12],"elaborated":[13],"constitutively":[14],"by":[15,23,41,64,158,300,345,381],"endothelial":[16,24,102,111,267,294,348,385],"cells":[17,112,217,268,349],"through":[18],"the":[19,42,44,58,65,71,80,85,93,161,177,247,253,281,366],"oxidation":[20],"l-arginine":[22],"NO":[25,39,62,77,99,181,251,295,343,359],"synthase.":[26],"Although":[27],"several":[28],"biochemical":[29],"agonists,":[30],"such":[31],"as":[32,166],"bradykinin,":[33],"have":[34,49,55,69],"been":[35,50],"shown":[36],"to":[37,133,219,244,257,276,354,371,383],"stimulate":[38],"production":[40,63,289,344,360],"endothelium,":[43,66],"effects":[45,72,86,248],"physical":[47],"factors":[48],"less":[51],"well":[52],"characterized.":[53],"We":[54],"previously":[56],"examined":[57,70],"shear-stress-dependent":[59],"induction":[60],"others":[68],"transmural":[74],"pressure":[75],"on":[76,101,115,252],"production.":[78],"In":[79,176,241,280],"current":[81],"study,":[82],"we":[83,263,315],"analyzed":[84],"cyclic":[88,140,184,204,261,278,287,355],"strain":[89,141,185,205,221,375],"or":[90,138],"load":[91],"in":[92,119,154,192,210,320,332,361,363],"presence":[94,282],"absence":[96,178],"an":[98,180,242,327],"agonist":[100],"cell":[103,168,174,223,321,386],"proliferation.":[104,387],"METHODS":[105],"AND":[106],"RESULTS:":[107],"Subconfluent":[108],"human":[109,265,346],"microvascular":[110,266,347],"were":[113,156,167,298],"grown":[114],"deformable":[116],"culture":[117],"plates":[118],"media":[120,155],"containing":[121],"10%":[122],"fetal":[123],"bovine":[124],"serum":[125],"1":[127,146,270],"mM":[128],"l-arginine,":[129],"then":[131],"subjects":[132],"either":[134],"0,":[135],"11,":[136],"18,":[137],"27%":[139,220,277,286],"at":[142,160],"frequency":[144],"Hz.":[147],"Nitrogen":[148],"oxides":[149,194,212,292],"(S-nitrosothiols":[150],"free":[152],"NO)":[153],"measured":[157],"photolysis-chemiluminescence":[159],"end":[162],"24":[164],"hours,":[165],"number,":[169],"[(3)H]thymidine":[170,230,333],"incorporation,":[171],"total":[173],"protein.":[175],"agonist,":[182],"11%":[183],"produced":[186,206],"73":[188],"+/-":[189,227,234,302,306,324,329],"17%":[190],"increase":[191,209,319,331],"nitrogen":[193,211,291],"compared":[195,213,238,311],"with":[196,214,239,269,312],"control":[197],"(P":[198,309,335],"<.05),":[199],"whereas":[200],"18":[201],"27":[203],"no":[207,317],"significant":[208,318],"control.":[215,240],"However,":[216],"subjected":[218,274,370],"increased":[222,299,372],"number":[224,322],"(by":[225,232],"98":[226],"17%)":[228],"incorporation":[231,334],"16":[233],"4%,":[235],"P":[236],"<.05)":[237],"attempt":[243],"examine":[245],"further":[246],"endogenous":[250,342],"cells'":[254],"proliferation":[255],"response":[256,353],"increasing":[258],"levels":[259,373],"strain,":[262,288],"incubated":[264],"\u00b5M":[271],"bradykinin":[272,284],"them":[275],"strain.":[279,356],"synthase":[296],"activity":[297],"110":[301],"37%":[303],"135":[305],"7%,":[307],"respectively":[308],"<.05":[310],"control);":[313],"however,":[314],"observed":[316],"(5":[323],"5%),":[325],"despite":[326],"86":[328],"7%":[330],"<.05).":[336],"CONCLUSION:":[337],"These":[338],"results":[339],"suggest":[340],"that":[341,368],"regulates":[350],"their":[351],"growth":[352],"Modulation":[357],"vivo":[362],"areas":[364],"vasculature":[367],"are":[369],"may":[376],"represent":[377],"one":[378],"potential":[379],"mechanism":[380],"which":[382],"alter":[384]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
