{"id":"https://openalex.org/W2059634360","doi":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","title":"Intestinal microbial conversion of cholesterol to coprostanol in man","display_name":"Intestinal microbial conversion of cholesterol to coprostanol in man","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2059634360","doi":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","mag":"2059634360","pmid":"https://pubmed.ncbi.nlm.nih.gov/2223037"},"language":"en","primary_location":{"id":"doi:10.1111/j.1699-0463.1990.tb05004.x","doi":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","pdf_url":null,"source":{"id":"https://openalex.org/S135377718","display_name":"Apmis","issn_l":"0903-4641","issn":["0903-4641","1600-0463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017555502","display_name":"Tore Midtvedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"T. Midtvedt","raw_affiliation_strings":["Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109091752","display_name":"E. Lingaas","orcid":"https://orcid.org/0009-0008-3702-2859","observed_orcids":["https://orcid.org/0009-0008-3702-2859"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"E. Lingaas","raw_affiliation_strings":["Kaptein W. Wilhelmsen og Rues Bacteriological Institute, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaptein W. Wilhelmsen og Rues Bacteriological Institute, National Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031248357","display_name":"Bodil Carlstedt\u2010Duke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B. Carlstedt\u2010Duke","raw_affiliation_strings":["Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065633552","display_name":"Torgeir H\u00f8verstad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. H\u00d6Verstad","raw_affiliation_strings":["Department of Medicine A, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine A, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113731765","display_name":"Ann\u2010Christine Midtvedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. C. Midtvedt","raw_affiliation_strings":["Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075972250","display_name":"Henri Saxerholt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H. Saxerholt","raw_affiliation_strings":["Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030642397","display_name":"Martin Steinbakk","orcid":"https://orcid.org/0000-0001-6406-1812","observed_orcids":["https://orcid.org/0000-0001-6406-1812"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"M. Steinbakk","raw_affiliation_strings":["Kaptein W. Wilhelmsen og Rues Bacteriological Institute, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaptein W. Wilhelmsen og Rues Bacteriological Institute, National Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087843535","display_name":"K. E. Norin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"K. E. Norin","raw_affiliation_strings":["Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017555502"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":null,"fwci":0.3588,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.52450654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"98","issue":"7-12","first_page":"839","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5659999847412109},{"id":"https://openalex.org/keywords/coprostanol","display_name":"coprostanol","score":1.0},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antibiotic-effects-on-gut-flora","display_name":"antibiotic effects on gut flora","score":0.6629999876022339},{"id":"https://openalex.org/keywords/anaerobic-gram-positive-bacteria","display_name":"anaerobic Gram-positive bacteria","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bile-acid-synthesis","display_name":"bile acid synthesis","score":0.5600000023841858},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.6620000004768372},{"id":"https://openalex.org/keywords/clindamycin","display_name":"clindamycin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.6819999814033508},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nalidixic-acid","display_name":"nalidixic acid","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ofloxacin","display_name":"ofloxacin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bacitracin","display_name":"bacitracin","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2777585577","wikidata":"https://www.wikidata.org/wiki/Q5168983","display_name":"Coprostanol","level":4,"score":0.8796868324279785},{"id":"https://openalex.org/C2779860364","wikidata":"https://www.wikidata.org/wiki/Q61954719","display_name":"Bacitracin","level":3,"score":0.6270392537117004},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6248210668563843},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.6193062663078308},{"id":"https://openalex.org/C2775876089","wikidata":"https://www.wikidata.org/wiki/Q281082","display_name":"Nalidixic acid","level":4,"score":0.5833934545516968},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.5281491279602051},{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.518682599067688},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.5121293067932129},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4974267780780792},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4837810695171356},{"id":"https://openalex.org/C2780626017","wikidata":"https://www.wikidata.org/wiki/Q1321320","display_name":"Tinidazole","level":4,"score":0.47830894589424133},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.446821391582489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40130555629730225},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.39091673493385315},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34074413776397705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32630792260169983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3034176826477051},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.22469624876976013},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15969008207321167},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.11126479506492615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004083","descriptor_name":"Cholestanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1699-0463.1990.tb05004.x","doi":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1699-0463.1990.tb05004.x","pdf_url":null,"source":{"id":"https://openalex.org/S135377718","display_name":"Apmis","issn_l":"0903-4641","issn":["0903-4641","1600-0463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS","raw_type":"journal-article"},{"id":"pmid:2223037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2223037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W122697214","https://openalex.org/W1568836064","https://openalex.org/W1772798798","https://openalex.org/W1973337008","https://openalex.org/W1974892612","https://openalex.org/W1991999444","https://openalex.org/W2016348640","https://openalex.org/W2017077333","https://openalex.org/W2017973950","https://openalex.org/W2020287445","https://openalex.org/W2039031456","https://openalex.org/W2053197082","https://openalex.org/W2080463137","https://openalex.org/W2134149420","https://openalex.org/W2416660116"],"related_works":["https://openalex.org/W1991999444","https://openalex.org/W3197553619","https://openalex.org/W1986418038","https://openalex.org/W2046142611","https://openalex.org/W2081778245","https://openalex.org/W2151941036","https://openalex.org/W2034976321","https://openalex.org/W2158538399","https://openalex.org/W4392273476","https://openalex.org/W2974988722"],"abstract_inverted_index":{"The":[0],"intestinal":[1,145],"microbial":[2],"conversion":[3,59,80,116,146],"of":[4,13,50,60,70,96,117,130,147,156],"cholesterol":[5,51,118],"to":[6,81,119,124],"coprostanol":[7,120],"has":[8],"been":[9],"measured":[10],"in":[11,94,103,143,151],"groups":[12,85,105],"healthy":[14],"subjects":[15,45,114],"before,":[16],"during":[17],"and":[18,75],"after":[19,127],"they":[20,41],"received":[21,42],"the":[22,44,62,79,84,97,104,128,131,144,152,157],"antibiotics":[23,139],"ampicillin,":[24],"bacitracin,":[25,71],"clindamycin,":[26,72],"co-trimoxazole,":[27,107],"doxycycline,":[28,89],"erythromycin,":[29,73],"metronidazole,":[30],"nalidixic":[31,108],"acid,":[32],"ofloxacin":[33],"or":[34,66,88,110],"vancomycin":[35,76],"orally":[36,137],"for":[37],"6":[38,113],"days.":[39],"Before":[40],"antibiotics,":[43],"demonstrated":[46],"two":[47],"distinct":[48],"patterns":[49],"conversion.":[52,68],"One":[53],"pattern":[54],"was":[55,121],"characterised":[56],"by":[57,64],"extensive":[58],"cholesterol,":[61,148],"other":[63],"little":[65],"no":[67,115],"Intake":[69],"metronidazole":[74],"significantly":[77],"reduced":[78],"coprostanol.":[82],"In":[83,112],"receiving":[86,106],"ampicillin":[87],"marked":[90],"reductions":[91],"were":[92,101],"found":[93,102,122],"most":[95],"subjects.":[98],"No":[99],"alterations":[100,142],"acid":[109],"ofloxacin.":[111],"up":[123],"5":[125],"weeks":[126],"end":[129],"antibiotic":[132],"intake.":[133],"We":[134],"conclude":[135],"that":[136],"given":[138],"may":[140],"cause":[141],"reflecting":[149],"changes":[150],"anaerobic,":[153],"Gram-positive":[154],"component":[155],"gut":[158],"flora.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
