{"id":"https://openalex.org/W2059633914","doi":"https://doi.org/10.1097/00024382-199901000-00004","title":"MAJOR BURN TRAUMA IN RATS PROMOTES CARDIAC AND GASTROINTESTINAL APOPTOSIS","display_name":"MAJOR BURN TRAUMA IN RATS PROMOTES CARDIAC AND GASTROINTESTINAL APOPTOSIS","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2059633914","doi":"https://doi.org/10.1097/00024382-199901000-00004","mag":"2059633914","pmid":"https://pubmed.ncbi.nlm.nih.gov/9921713"},"language":"en","primary_location":{"id":"doi:10.1097/00024382-199901000-00004","doi":"https://doi.org/10.1097/00024382-199901000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199901000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044339862","display_name":"Ellis Lightfoot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ellis Lightfoot","raw_affiliation_strings":["Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235-9160, USA","Departments of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235-9160, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Departments of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110146917","display_name":"Jureta W. Horton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jureta W. Horton","raw_affiliation_strings":["Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655281","display_name":"David L. Maass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Maass","raw_affiliation_strings":["Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108451663","display_name":"D. Jean White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Jean White","raw_affiliation_strings":["Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080700269","display_name":"Richard McFarland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. McFarland","raw_affiliation_strings":["Departments of Pathology, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["Departments of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75235","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043874873","https://openalex.org/A5044339862"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":4.3645,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.94251569,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"29","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cardiac-apoptosis","display_name":"cardiac apoptosis","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.5049999952316284},{"id":"https://openalex.org/keywords/left-ventricular-pressure","display_name":"left ventricular pressure","score":0.6899999976158142},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lactated-ringer-s-solution","display_name":"lactated Ringer's solution","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8346781730651855},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.8326798677444458},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7093226313591003},{"id":"https://openalex.org/C2993242423","wikidata":"https://www.wikidata.org/wiki/Q170518","display_name":"Burn injury","level":2,"score":0.634183406829834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6217896342277527},{"id":"https://openalex.org/C2777192170","wikidata":"https://www.wikidata.org/wiki/Q7429703","display_name":"Scalding","level":2,"score":0.612475574016571},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5913614630699158},{"id":"https://openalex.org/C2776782833","wikidata":"https://www.wikidata.org/wiki/Q3454235","display_name":"Total body surface area","level":2,"score":0.5128798484802246},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.46657049655914307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4462262988090515},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4333485960960388},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3834124207496643},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3472353219985962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2885945439338684},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20194846391677856},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.17424389719963074},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09521910548210144},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00024382-199901000-00004","doi":"https://doi.org/10.1097/00024382-199901000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199901000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:9921713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9921713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2854545836","display_name":"PATHOPHYSIOLOGICAL BIOCHEMICAL CHANGES OF THERMAL INJURY","funder_award_id":"P50GM021681","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4012713439","display_name":null,"funder_award_id":"GM 21681-33","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040872439","https://openalex.org/W2041520121","https://openalex.org/W1976889996","https://openalex.org/W2319293309","https://openalex.org/W2018827447","https://openalex.org/W2139689453","https://openalex.org/W2020295337","https://openalex.org/W2202470118","https://openalex.org/W2386816311","https://openalex.org/W3176018743"],"abstract_inverted_index":{"The":[0,187],"hypothesis":[1],"that":[2,6,234,241],"cardiac":[3,21,198,239,252],"functional":[4],"abnormalities":[5],"occur":[7],"after":[8,96,146,243],"major":[9],"burn":[10,34,51,66,69,97,147,229,244],"trauma":[11,245],"are":[12],"paralleled":[13,193],"by":[14,74,170,194],"an":[15],"increased":[16,169,213],"incidence":[17],"of":[18,37,90,104,112,119,130,141,165,183,189,237],"apoptosis":[19,91,214,221,236],"in":[20,109,135,154,157,179,197,204,215,222,248],"myocytes":[22,240],"was":[23,107,150,176,192],"examined.":[24],"Adult":[25],"Sprague-Dawley":[26],"rats":[27,56],"were":[28,44,57,71,133],"given":[29],"a":[30,127,151,195],"full":[31],"thickness":[32],"scald":[33],"comprising":[35],"43+/-1%":[36],"the":[38,75,88,101,105,117,136,158,163,180,184,216,223,235,238],"total":[39],"body":[40],"surface":[41],"area":[42],"or":[43],"manipulated":[45],"identically":[46],"but":[47],"not":[48,226],"exposed":[49],"to":[50,86,250],"injury":[52,211],"(sham":[53],"burn);":[54],"burned":[55],"fluid":[58],"resuscitated":[59],"with":[60,201,228],"lactated":[61],"Ringer's":[62],"solution.":[63],"Tissues":[64,114],"from":[65,116],"and":[67,83,93,139,162,208],"sham":[68],"animals":[70,121],"then":[72],"examined":[73],"TUNEL":[76],"(TdT-mediated":[77],"dUTP":[78],"nick":[79],"end":[80],"labeling)":[81],"assay":[82],"light":[84],"microscopy":[85],"determine":[87],"presence":[89],"24":[92],"48":[94,172],"h":[95,173],"trauma.":[98,230],"In":[99],"parallel,":[100],"mechanical":[102,199,253],"function":[103,200],"heart":[106],"assayed":[108],"separate":[110],"groups":[111],"rats.":[113],"harvested":[115],"hearts":[118],"sham-treated":[120,142],"showed":[122],"essentially":[123],"no":[124],"apoptosis,":[125],"whereas":[126,220],"small":[128,217],"number":[129,164],"apoptotic":[131,155,166,190],"cells":[132,156,167,191],"noted":[134,177],"intestinal":[137],"villi":[138],"liver":[140,224],"animals.":[143],"Twenty-four":[144],"hours":[145],"trauma,":[148],"there":[149],"marked":[152],"increase":[153,227],"left":[159,185,205],"ventricle":[160],"(+916%),":[161],"remained":[168],"eightfold":[171],"postburn.":[174],"Apoptosis":[175],"predominately":[178],"subendocardial":[181],"tissue":[182],"ventricle.":[186],"appearance":[188],"decrease":[196],"significant":[202],"decreases":[203],"ventricular":[206],"pressure":[207],"+/-dP/dt(max).":[209],"Burn":[210],"also":[212],"intestine":[218],"significantly,":[219],"did":[225],"These":[231],"data":[232],"suggest":[233],"occurs":[242],"may":[246],"contribute,":[247],"part,":[249],"postburn":[251],"dysfunction.":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
