{"id":"https://openalex.org/W2059583192","doi":"https://doi.org/10.1185/03007990802583845","title":"Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa","display_name":"Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa","publication_year":2008,"publication_date":"2008-11-18","ids":{"openalex":"https://openalex.org/W2059583192","doi":"https://doi.org/10.1185/03007990802583845","mag":"2059583192","pmid":"https://pubmed.ncbi.nlm.nih.gov/19032135"},"language":"en","primary_location":{"id":"doi:10.1185/03007990802583845","doi":"https://doi.org/10.1185/03007990802583845","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007990802583845","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032535811","display_name":"Margaret Drehobl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Margaret Drehobl","raw_affiliation_strings":["Scripps Clinic, Clinical Research, San Diego, CA 92128, USA. Drehobl.Margaret@scrippshealth.org","Scripps Clinic, Clinical Research, San Diego, CA 92128, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Clinic, Clinical Research, San Diego, CA 92128, USA. Drehobl.Margaret@scrippshealth.org","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Scripps Clinic, Clinical Research, San Diego, CA 92128, USA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071250389","display_name":"Juan Lorente","orcid":"https://orcid.org/0000-0002-3264-0251","observed_orcids":["https://orcid.org/0000-0002-3264-0251"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Lorente Guerrero","raw_affiliation_strings":["Hospital Universitari Vall d\u2019Hebr\u00f3n, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari Vall d\u2019Hebr\u00f3n, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084288555","display_name":"Pilar Rivas-Lacarte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096656","display_name":"Hospital de Viladecans","ror":"https://ror.org/00t4w1v80","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096656"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Rivas Lacarte","raw_affiliation_strings":["Hospital de Viladecans, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Viladecans, Barcelona, Spain","institution_ids":["https://openalex.org/I4210096656"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gary Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165277","display_name":"Tampa Bay Medical Research","ror":"https://ror.org/05bhs6b69","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210165277"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Goldstein","raw_affiliation_strings":["Tampa Bay Medical Research, Inc., Palm Harbor, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampa Bay Medical Research, Inc., Palm Harbor, FL, USA","institution_ids":["https://openalex.org/I4210165277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004527595","display_name":"F. Sabater Mata De La Barata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Sabater Mata","raw_affiliation_strings":["Hospital Cl\u00ednic i Provincial, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044576161","display_name":"Stephen Luber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136119","display_name":"Rockwood Clinic","ror":"https://ror.org/046syc687","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Luber","raw_affiliation_strings":["Rockwood Clinic, Spokane, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockwood Clinic, Spokane, WA, USA","institution_ids":["https://openalex.org/I4210136119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032535811"],"corresponding_institution_ids":["https://openalex.org/I4210146328"],"apc_list":null,"apc_paid":null,"fwci":2.3646,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87949803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"12","first_page":"3531","last_page":"3542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.31929999589920044,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.8880000114440918},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/otalgia","display_name":"otalgia","score":0.6620000004768372},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5740000009536743},{"id":"https://openalex.org/keywords/children-adolescents-and-adults","display_name":"children, adolescents and adults","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clinical-cure-rate","display_name":"clinical cure rate","score":0.5130000114440918},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520550966262817},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.9035778045654297},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6082607507705688},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5238547325134277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5138764381408691},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4622459411621094},{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.4139869809150696},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37290340662002563},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.33151060342788696},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32637500762939453},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.052449703216552734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010032","descriptor_name":"Otitis Externa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019999","descriptor_name":"Pharmaceutical Solutions","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019999","descriptor_name":"Pharmaceutical Solutions","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1185/03007990802583845","doi":"https://doi.org/10.1185/03007990802583845","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007990802583845","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:19032135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19032135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317188","display_name":"Janssen Scientific Affairs","ror":"https://ror.org/04w4xsz15"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W184587488","https://openalex.org/W1547493004","https://openalex.org/W1606431564","https://openalex.org/W1969535434","https://openalex.org/W1985933892","https://openalex.org/W1992756895","https://openalex.org/W1995753136","https://openalex.org/W1999302204","https://openalex.org/W2001028523","https://openalex.org/W2008040853","https://openalex.org/W2017918003","https://openalex.org/W2029899341","https://openalex.org/W2033879664","https://openalex.org/W2040781991","https://openalex.org/W2051081446","https://openalex.org/W2078001265","https://openalex.org/W2078711214","https://openalex.org/W2080984895","https://openalex.org/W2081075970","https://openalex.org/W2093664920","https://openalex.org/W2094956788","https://openalex.org/W2100750517","https://openalex.org/W2107735508","https://openalex.org/W2126069489","https://openalex.org/W2133308029","https://openalex.org/W2163398872","https://openalex.org/W2167036679","https://openalex.org/W2197937885","https://openalex.org/W2219996007","https://openalex.org/W2334129939","https://openalex.org/W2397626928","https://openalex.org/W2411523386","https://openalex.org/W2413750710","https://openalex.org/W2418680845","https://openalex.org/W2439004981","https://openalex.org/W2473652304","https://openalex.org/W4255294947"],"related_works":["https://openalex.org/W2078711214","https://openalex.org/W2067529218","https://openalex.org/W2100750517","https://openalex.org/W2117836973","https://openalex.org/W4285386586","https://openalex.org/W2067098971","https://openalex.org/W2034536439","https://openalex.org/W2133308029","https://openalex.org/W2042858175","https://openalex.org/W2126069489"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,19,53,60,128,139,154,213,219,244,251,257,293,311,347],"efficacy":[4,44,84,185],"and":[5,29,64,71,79,135,163,188,196,216,254,278,297,301,330],"safety":[6],"of":[7,21,49,66,75,89,122,146,165,174,225,229,262,266,289,295,332,349],"ciprofloxacin":[8,95,134,147,175,187,214,230,252,335],"otic":[9,16,316,336],"solution":[10,17,317,337],"0.2%":[11,318,338],"to":[12,94,115,118,151,180,234,271,280,309,321,324],"polymyxin":[13],"B-neomycin-hydrocortisone":[14],"(PNH)":[15],"in":[18,26,144,161,172,212,218,227,264,283],"treatment":[20,140,170,223,285,348],"acute":[22,350],"diffuse":[23],"otitis":[24,50,351],"externa":[25],"children,":[27],"adolescents,":[28],"adults.":[30],"METHODS:":[31],"This":[32,326],"was":[33,46,113,131,142,159,210,248,319],"a":[34,169,222,340],"randomized,":[35],"parallel-group,":[36],"evaluator-blind,":[37],"active-controlled,":[38],"multicenter,":[39],"noninferiority":[40],"study.":[41],"The":[42,120,198],"primary":[43],"endpoint":[45],"clinical":[47,69,125,157,199,245],"cure":[48,58,126,158,200,246],"symptoms":[51,298],"at":[52,59,77,127,299],"test-of-cure":[54],"(TOC)":[55],"visit.":[56],"Clinical":[57],"end-of-treatment":[61],"(EOT)":[62],"visit":[63,130],"percentages":[65],"patients":[67,91,123,203,237],"with":[68,124,133,137,168,204,238],"improvement":[70,74],"resolution":[72],"and/or":[73],"otalgia":[76],"EOT":[78,155],"TOC":[80,129],"visits":[81],"were":[82,92,276],"secondary":[83,184],"endpoints.":[85],"RESULTS:":[86],"A":[87,287],"total":[88],"630":[90],"randomized":[93],"twice":[96],"daily":[97,105],"(n":[98,106],"=":[99,107],"318)":[100],"or":[101],"PNH":[102,189,220,258],"3":[103],"times":[104],"312)":[108],"for":[109,202,236,250,256,346],"7":[110],"days.":[111],"Ciprofloxacin":[112,315],"shown":[114],"be":[116,322],"noninferior":[117,323],"PNH.":[119,325],"percentage":[121],"86.6%":[132],"81.1%":[136],"PNH;":[138],"difference":[141,171,224,261],"5.6%":[143],"favor":[145,173,228,265],"(95%":[148,231],"CI:":[149,178,232,269],"-0.9":[150],"12.1).":[152],"At":[153],"visit,":[156],"achieved":[160],"70.0%":[162],"60.5%":[164],"patients,":[166],"respectively,":[167],"(9.5%,":[176],"95":[177],"1.2":[179],"17.9).":[181],"In":[182],"all":[183],"variables,":[186],"showed":[190],"similar":[191],"results,":[192],"including":[193],"pain":[194],"duration":[195],"resolution.":[197],"rate":[201,247],"baseline":[205,239,300],"cultures":[206,240],"showing":[207,241],"P.":[208],"aeruginosa":[209],"87.5%":[211],"group":[215,253,259],"78.6%":[217],"group,":[221],"8.9%":[226],"0.6":[233],"17.3);":[235],"S.":[242],"aureus,":[243],"72.7%":[249],"75.9%":[255],"(treatment":[260],"3.1%":[263],"PNH,":[267],"95%":[268],"-21.1%":[270],"27.4%).":[272],"Most":[273],"adverse":[274],"events":[275],"mild":[277],"unrelated":[279],"study":[281,291],"medication":[282],"both":[284],"groups.":[286],"limitation":[288],"this":[290],"is":[292],"assessment":[294],"signs":[296],"after":[302],"treatment,":[303],"which":[304],"does":[305],"not":[306],"provide":[307],"data":[308],"evaluate":[310],"interim":[312],"response.":[313],"CONCLUSIONS:":[314],"found":[320],"efficacy,":[327],"good":[328],"tolerability,":[329],"ease":[331],"administration":[333],"make":[334],"without":[339],"topical":[341],"steroid":[342],"an":[343],"attractive":[344],"option":[345],"externa.":[352]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
