{"id":"https://openalex.org/W2059519293","doi":"https://doi.org/10.1213/00000539-198512000-00012","title":"Decreased Incidence and Mortality of Anaphylaxis to Chymopapain","display_name":"Decreased Incidence and Mortality of Anaphylaxis to Chymopapain","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W2059519293","doi":"https://doi.org/10.1213/00000539-198512000-00012","mag":"2059519293","pmid":"https://pubmed.ncbi.nlm.nih.gov/2865910"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-198512000-00012","doi":"https://doi.org/10.1213/00000539-198512000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198512000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111540182","display_name":"Jonathan Moss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan Moss","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030022752","display_name":"Michael F. Roizen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Roizen","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012141761","display_name":"Eugene J. Nordby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene J. Nordby","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079267921","display_name":"Ronald A. Thisted","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Thisted","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020257221","display_name":"Jeffrey L. Apfelbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Apfelbaum","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033323547","display_name":"Bruce D. Schreider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Schreider","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110139242","display_name":"DANIEL J. McDERMOTT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. McDermott","raw_affiliation_strings":["Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","and Smith Laboratories, Northbrook, Illinois","the Department of Surgery, University of Wisconsin, Madison, Wisconsin","the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","Accepted for publication July 2, 1985","Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","Smith Laboratories, Northbrook, Illinois","Supported in part by IPOI #AG 03104-03, 04"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"and Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"the Department of Surgery, University of Wisconsin, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"the Departments of Anesthesia, Medicine, and Pharmacology, University of CalifoRNia, San Francisco, CalifoRNia","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Statistics and Anesthesia & Critical Care, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Accepted for publication July 2, 1985","institution_ids":[]},{"raw_affiliation_string":"Presented in part at the annual scientific meeting of the InteRNational Anesthesia Research Society, New Orleans, March 1983","institution_ids":[]},{"raw_affiliation_string":"Smith Laboratories, Northbrook, Illinois","institution_ids":[]},{"raw_affiliation_string":"Supported in part by IPOI #AG 03104-03, 04","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111540182"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I136199984","https://openalex.org/I180670191","https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.3936,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.56305372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64","issue":"12","first_page":"1197???1201","last_page":"1197???1201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.16019999980926514,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chymopapain","display_name":"chymopapain","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chemonucleolysis","display_name":"chemonucleolysis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.453000009059906},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.972000002861023},{"id":"https://openalex.org/keywords/antihistamine-prophylaxis","display_name":"antihistamine prophylaxis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ige-antibodies","display_name":"IgE antibodies","score":0.9549999833106995},{"id":"https://openalex.org/keywords/overdiagnosis","display_name":"overdiagnosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.957922637462616},{"id":"https://openalex.org/C2780605044","wikidata":"https://www.wikidata.org/wiki/Q5118581","display_name":"Chymopapain","level":2,"score":0.9491150975227356},{"id":"https://openalex.org/C2775933838","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylaxis","level":3,"score":0.9429155588150024},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7140955924987793},{"id":"https://openalex.org/C2909843257","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylactic reactions","level":4,"score":0.6402350664138794},{"id":"https://openalex.org/C2779377019","wikidata":"https://www.wikidata.org/wiki/Q956131","display_name":"Overdiagnosis","level":2,"score":0.5950444936752319},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43351465463638306},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39518341422080994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3839094638824463},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3448111414909363},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2791016697883606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20420676469802856},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000772","descriptor_name":"Anesthesia, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002917","descriptor_name":"Chymopapain","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/00000539-198512000-00012","doi":"https://doi.org/10.1213/00000539-198512000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198512000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:2865910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2865910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2045520306","display_name":null,"funder_award_id":"AG 03104-03","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4959500010","display_name":null,"funder_award_id":"AG 03104-04","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972609181","https://openalex.org/W1970129939","https://openalex.org/W2048177478","https://openalex.org/W2062161183","https://openalex.org/W2016267862","https://openalex.org/W4236486908","https://openalex.org/W24073552","https://openalex.org/W2286755986","https://openalex.org/W291361953","https://openalex.org/W2041983832"],"abstract_inverted_index":{"A":[0],"recognized":[1],"side":[2],"effect":[3],"of":[4,15,19,47,54,77,108,127,135],"chemonucleolysis":[5,136],"is":[6],"life-threatening":[7],"anaphylaxis":[8,20,55,91,128],"to":[9,39,57,72,90,123,142],"chymopapain.":[10],"In":[11],"the":[12,43,52,60,75,117,130,149],"clinical":[13,82,131],"trials":[14,132],"chymopapain,":[16],"13":[17],"cases":[18],"were":[21,37],"reported":[22,101],"in":[23,59,80,93,120,129,137,146,151],"1585":[24],"administrations":[25,96],"(0.82%).":[26],"Two":[27],"patients":[28,138],"died.":[29],"Data":[30],"from":[31,87],"a":[32,64],"postmarketing":[33],"survey":[34],"(48,239":[35],"questionnaires)":[36],"reviewed":[38],"identify":[40],"factors":[41],"influencing":[42],"incidence":[44,53,76],"and":[45,110,133],"severity":[46],"anaphylaxis.":[48,124],"The":[49,105],"results":[50],"indicate":[51],"decreased":[56],"0.44%":[58],"1983-1984":[61],"period":[62],"(126/23,736),":[63],"level":[65],"significantly":[66],"(P":[67],"less":[68],"than":[69],"or":[70],"equal":[71],"0.001)":[73],"below":[74],"0.82%":[78],"observed":[79],"initial":[81],"trials.":[83],"Only":[84],"three":[85],"deaths":[86],"complications":[88],"related":[89],"occurred":[92],"approximately":[94],"75,000":[95],"(producing":[97],"252":[98],"anaphylactic":[99],"episodes)":[100],"since":[102],"December":[103],"1982.":[104],"prophylactic":[106],"use":[107],"antihistamines":[109],"pretreatment":[111],"with":[112,116,139],"intravenous":[113],"fluids":[114],"coincide":[115],"dramatic":[118],"reduction":[119,150],"mortality":[121],"due":[122],"However,":[125],"overdiagnosis":[126],"avoidance":[134],"IgE":[140],"antibodies":[141],"chymopapain":[143],"may":[144],"account,":[145],"part,":[147],"for":[148],"incidence.":[152]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
