{"id":"https://openalex.org/W2059512467","doi":"https://doi.org/10.1089/gtmb.2009.0068","title":"Association of EGFR and HER2 Polymorphisms with Risk and Clinical Features of Thyroid Cancer","display_name":"Association of EGFR and HER2 Polymorphisms with Risk and Clinical Features of Thyroid Cancer","publication_year":2009,"publication_date":"2009-10-27","ids":{"openalex":"https://openalex.org/W2059512467","doi":"https://doi.org/10.1089/gtmb.2009.0068","mag":"2059512467","pmid":"https://pubmed.ncbi.nlm.nih.gov/19860576"},"language":"en","primary_location":{"id":"doi:10.1089/gtmb.2009.0068","doi":"https://doi.org/10.1089/gtmb.2009.0068","is_oa":false,"landing_page_url":"https://doi.org/10.1089/gtmb.2009.0068","pdf_url":null,"source":{"id":"https://openalex.org/S96572642","display_name":"Genetic Testing and Molecular Biomarkers","issn_l":"1945-0257","issn":["1945-0257","1945-0265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Testing and Molecular Biomarkers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111936256","display_name":"Maha Reba\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Maha Reba\u00ef","raw_affiliation_strings":["Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002601833","display_name":"Imen Kallel","orcid":"https://orcid.org/0000-0001-9139-4233","observed_orcids":["https://orcid.org/0000-0001-9139-4233"]},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Imen Kallel","raw_affiliation_strings":["Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039793801","display_name":"Fatma Hamza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Fatma Hamza","raw_affiliation_strings":["Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082140342","display_name":"Salma Charfeddine","orcid":"https://orcid.org/0000-0003-4047-0608","observed_orcids":["https://orcid.org/0000-0003-4047-0608"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Salma Charfeddine","raw_affiliation_strings":["Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057384490","display_name":"R Kaffel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Raja Kaffel","raw_affiliation_strings":["Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078356091","display_name":"Fadhel Guermazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Fadhel Guermazi","raw_affiliation_strings":["Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Nuclear Medicine, Habib Bourguiba Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018677572","display_name":"Ahmed Reba\u00ef","orcid":"https://orcid.org/0000-0002-8954-8683","observed_orcids":["https://orcid.org/0000-0002-8954-8683"]},"institutions":[{"id":"https://openalex.org/I4210162466","display_name":"Centre of Biotechnology of Sfax","ror":"https://ror.org/05acynk65","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210162466"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Ahmed Reba\u00ef","raw_affiliation_strings":["Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Bioinformatics, Biostatistics and Signalling, Centre of Biotechnology of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210162466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018677572"],"corresponding_institution_ids":["https://openalex.org/I4210162466"],"apc_list":null,"apc_paid":null,"fwci":0.3954,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66270971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"13","issue":"6","first_page":"779","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8889999985694885},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6949999928474426},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6660000085830688},{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5989999771118164},{"id":"https://openalex.org/keywords/esr1","display_name":"ESR1","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6607354879379272},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.645011842250824},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6187167763710022},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6071146130561829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6011921167373657},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5551804304122925},{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.5427295565605164},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5305269956588745},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.523653507232666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43307065963745117},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.43302828073501587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43065422773361206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4058253765106201},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3463650941848755},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2612587809562683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2023332715034485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18917223811149597}],"mesh":[{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/gtmb.2009.0068","doi":"https://doi.org/10.1089/gtmb.2009.0068","is_oa":false,"landing_page_url":"https://doi.org/10.1089/gtmb.2009.0068","pdf_url":null,"source":{"id":"https://openalex.org/S96572642","display_name":"Genetic Testing and Molecular Biomarkers","issn_l":"1945-0257","issn":["1945-0257","1945-0265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Testing and Molecular Biomarkers","raw_type":"journal-article"},{"id":"pmid:19860576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19860576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic testing and molecular biomarkers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W51995314","https://openalex.org/W205541777","https://openalex.org/W1486000143","https://openalex.org/W1494822360","https://openalex.org/W1557061959","https://openalex.org/W1981944639","https://openalex.org/W1984658341","https://openalex.org/W1997286033","https://openalex.org/W2014938285","https://openalex.org/W2037644310","https://openalex.org/W2049449785","https://openalex.org/W2056439434","https://openalex.org/W2089881061","https://openalex.org/W2100579510","https://openalex.org/W2123864870","https://openalex.org/W2134333581","https://openalex.org/W2143600397","https://openalex.org/W2145938909","https://openalex.org/W2148174696","https://openalex.org/W2150910107","https://openalex.org/W2153164684","https://openalex.org/W2326850811","https://openalex.org/W2414119535","https://openalex.org/W2443808740","https://openalex.org/W2788320203","https://openalex.org/W2804007336","https://openalex.org/W3141948287","https://openalex.org/W3188902609"],"related_works":["https://openalex.org/W2150910107","https://openalex.org/W2148565950","https://openalex.org/W4200317955","https://openalex.org/W2770403273","https://openalex.org/W4413875687","https://openalex.org/W1988914788","https://openalex.org/W2095014871","https://openalex.org/W2119015742","https://openalex.org/W7120312784","https://openalex.org/W3128105649"],"abstract_inverted_index":{"The":[0,62],"epidermal":[1],"growth":[2],"factor":[3],"receptor":[4,191,195],"family":[5],"plays":[6],"a":[7,31,206],"critical":[8],"role":[9],"in":[10,21,30,80,108,111,187,216],"the":[11,22,41,52,81,88,92,99,102,138,188,220,229,235],"control":[12,93],"of":[13,33,43,51,87,120,219],"many":[14],"physiological":[15],"processes.":[16],"Genetic":[17],"alterations":[18],"and/or":[19],"variations":[20],"gene":[23],"encoding":[24],"these":[25,141],"receptors":[26],"have":[27,135],"been":[28],"implicated":[29],"variety":[32],"human":[34],"cancers.":[35],"In":[36,223],"this":[37],"study":[38],"we":[39],"evaluate":[40],"association":[42,167],"two":[44,142,183],"single-nucleotide":[45],"polymorphisms":[46],"(SNP),":[47],"R497K":[48,90],"and":[49,54,70,83,94,113,145,163,193,200,211],"I655V,":[50,101,232],"EGFR":[53,236],"HER2":[55,177,231],"genes,":[56],"respectively,":[57],"with":[58,66,116,176,182,240],"thyroid":[59,72,121,189,241],"cancer":[60,73,122,242],"risk.":[61,243],"analysis":[63],"was":[64,78,114,168,172,238],"performed":[65],"302":[67],"healthy":[68],"individuals":[69],"106":[71],"patients.":[74],"No":[75,165],"significant":[76,166],"difference":[77],"found":[79,173],"allelic":[82],"genotypic":[84],"frequency":[85],"distribution":[86],"SNP":[89,100,214,230],"between":[91,140,208],"patient":[95],"groups.":[96],"While":[97],"for":[98,213],"allele":[103],"G":[104],"is":[105],"more":[106],"frequent":[107],"patients":[109],"than":[110],"controls":[112],"associated":[115,175,239],"an":[117],"increased":[118],"risk":[119],"(odds":[123],"ratio":[124],"=":[125,132],"1.88;":[126],"95%":[127],"confidence":[128],"intervals:":[129],"1.18-3.01;":[130],"p":[131],"0.007).":[133],"We":[134,203],"also":[136,204],"investigated":[137],"relationship":[139],"polymorphic":[143],"sites":[144],"clinicopathological":[146],"characteristics":[147],"such":[148],"as":[149,179,181],"thyroid-stimulating":[150],"hormone":[151,190],"level,":[152],"off-thyroxin,":[153],"serum":[154],"thyroglobulin,":[155],"tumor":[156,159,161],"histology,":[157],"metastasis,":[158],"status,":[160],"stage,":[162],"survival.":[164],"observed.":[169],"Tumor":[170],"status":[171],"significantly":[174],"I655V":[178],"well":[180],"previously":[184],"studied":[185],"markers":[186],"A":[192],"estrogen":[194],"1":[196],"(ESR1)":[197],"genes":[198],"(D17S2189":[199],"D6S440,":[201],"respectively).":[202],"report":[205],"correlation":[207],"thyroglobulin":[209],"level":[210],"genotypes":[212],"rs2228480":[215],"exon":[217],"8":[218],"ESR1":[221],"gene.":[222],"conclusion,":[224],"our":[225],"results":[226],"suggest":[227],"that":[228],"but":[233],"not":[234],"R497K,":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}