{"id":"https://openalex.org/W2059484646","doi":"https://doi.org/10.3109/00365529008998541","title":"Proliferative Response of Different Exocrine Pancreatic Cell Types to Hormonal Stimuli","display_name":"Proliferative Response of Different Exocrine Pancreatic Cell Types to Hormonal Stimuli","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2059484646","doi":"https://doi.org/10.3109/00365529008998541","mag":"2059484646","pmid":"https://pubmed.ncbi.nlm.nih.gov/1703318"},"language":"en","primary_location":{"id":"doi:10.3109/00365529008998541","doi":"https://doi.org/10.3109/00365529008998541","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365529008998541","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074627961","display_name":"Thomas Gasslander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T. Gasslander","raw_affiliation_strings":["Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","Department of, Surgery, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of, Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870332","display_name":"Staffan Smeds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Smeds","raw_affiliation_strings":["Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","Department of, Surgery, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of, Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036270477","display_name":"Lennart Blomqvist","orcid":"https://orcid.org/0000-0003-1716-2439","observed_orcids":["https://orcid.org/0000-0003-1716-2439"]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Blomqvist","raw_affiliation_strings":["Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","Department of, Surgery, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of, Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037166555","display_name":"Ingemar Ihse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151885","display_name":"Link\u00f6ping University Hospital","ror":"https://ror.org/05h1aye87","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210151885"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"I. Ihse","raw_affiliation_strings":["Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","Department of, Surgery, University Hospital, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]},{"raw_affiliation_string":"Department of, Surgery, University Hospital, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I4210151885"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151885"],"apc_list":null,"apc_paid":null,"fwci":0.8532,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.72921379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"25","issue":"11","first_page":"1103","last_page":"1110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caerulein","display_name":"caerulein","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cholecystokinin-analogue","display_name":"cholecystokinin analogue","score":0.8980000019073486},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pancreatic-cell-proliferation","display_name":"pancreatic cell proliferation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ductal-cells","display_name":"ductal cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/centroacinar-cells","display_name":"centroacinar cells","score":1.0},{"id":"https://openalex.org/keywords/hormone-stimulation","display_name":"hormonal stimulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pancreatic-growth","display_name":"pancreatic growth","score":0.597000002861023},{"id":"https://openalex.org/keywords/dna-content","display_name":"DNA content","score":0.7059999704360962},{"id":"https://openalex.org/keywords/amylase","display_name":"amylase","score":0.7860000133514404},{"id":"https://openalex.org/keywords/3h-thymidine-labeling","display_name":"3H-thymidine labeling","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8178160190582275},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8155937790870667},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.7458612322807312},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7181068062782288},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.7098037004470825},{"id":"https://openalex.org/C2991930265","wikidata":"https://www.wikidata.org/wiki/Q5062943","display_name":"Acinar cell","level":3,"score":0.7084131240844727},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6614692211151123},{"id":"https://openalex.org/C2776731452","wikidata":"https://www.wikidata.org/wiki/Q5065299","display_name":"Ceruletide","level":4,"score":0.5553786754608154},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49282148480415344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49084264039993286},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.487105131149292},{"id":"https://openalex.org/C2778677841","wikidata":"https://www.wikidata.org/wiki/Q422301","display_name":"Secretin","level":3,"score":0.4686015844345093},{"id":"https://openalex.org/C57380142","wikidata":"https://www.wikidata.org/wiki/Q863089","display_name":"Pancreatic juice","level":3,"score":0.46556901931762695},{"id":"https://openalex.org/C2910215949","wikidata":"https://www.wikidata.org/wiki/Q641605","display_name":"Exocrine pancreas","level":3,"score":0.4575790762901306},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44570082426071167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32538488507270813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22374951839447021},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1375453770160675},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12883907556533813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07639452815055847},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/00365529008998541","doi":"https://doi.org/10.3109/00365529008998541","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365529008998541","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:1703318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1703318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmid:1703319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1703319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W5784831","https://openalex.org/W80058243","https://openalex.org/W177747808","https://openalex.org/W1000015476","https://openalex.org/W1495681474","https://openalex.org/W1539182109","https://openalex.org/W1595460832","https://openalex.org/W1775749144","https://openalex.org/W1973233717","https://openalex.org/W1977779461","https://openalex.org/W1995810025","https://openalex.org/W1998311918","https://openalex.org/W2000392964","https://openalex.org/W2017299602","https://openalex.org/W2035723358","https://openalex.org/W2038185198","https://openalex.org/W2038586985","https://openalex.org/W2057070381","https://openalex.org/W2070676862","https://openalex.org/W2084931137","https://openalex.org/W2085209511","https://openalex.org/W2086977264","https://openalex.org/W2089097582","https://openalex.org/W2133659850","https://openalex.org/W2152520963","https://openalex.org/W2157660661","https://openalex.org/W2191378245","https://openalex.org/W2247149472","https://openalex.org/W2408355230","https://openalex.org/W2408847242","https://openalex.org/W2408918285","https://openalex.org/W2409385721","https://openalex.org/W2411287195","https://openalex.org/W2416259695","https://openalex.org/W2423790871","https://openalex.org/W2433333435","https://openalex.org/W2605911230"],"related_works":["https://openalex.org/W2058214634","https://openalex.org/W4252107181","https://openalex.org/W2275337243","https://openalex.org/W579286376","https://openalex.org/W1965973311","https://openalex.org/W73711866","https://openalex.org/W2408355230","https://openalex.org/W1998311918","https://openalex.org/W2077541529","https://openalex.org/W2408531444"],"abstract_inverted_index":{"The":[0,111,201],"trophic":[1],"effect":[2],"on":[3,58],"the":[4,8,41,72,92,95,118,126,130,142,160,170,209,218,231],"exocrine":[5,60,210],"pancreas":[6,211],"of":[7,50,69,80,144,154,193,208],"cholecystokinin":[9,219],"analogue":[10,220],"cerulein":[11,51,81,155],"was":[12,64,115,122,139,156,166,180],"studied":[13,65],"in":[14,26,31,106,117,141,159,169,177,182,197,230],"a":[15,102,133],"long-term":[16],"experiment":[17,74,132],"(20":[18],"or":[19],"160":[20,55,152],"micrograms/kg/24":[21,56,78],"h":[22,79],"for":[23],"14":[24],"days)":[25],"mice":[27],"by":[28,47,66,125,217],"measuring":[29],"changes":[30],"pancreatic":[32,61,84,112],"weight":[33,85,100],"and":[34,37,86,88,101,108,151,185,222,233],"protein,":[35],"amylase,":[36],"DNA":[38,113],"content.":[39,110],"Further,":[40],"selective":[42],"cell":[43,62,162,178,187,206,227,235],"growth":[44,228],"stimulation":[45,229],"exerted":[46],"various":[48],"doses":[49],"(4,":[52],"20,":[53,149],"54,":[54,150],"h)":[57],"different":[59],"types":[63,207],"continuous":[67],"administration":[68],"3H-thymidine.":[70],"In":[71,129],"first":[73],"animals":[75,93],"given":[76,94],"20":[77],"had":[82,98],"increased":[83,196],"amylase":[87,107],"protein":[89,109],"content,":[90],"whereas":[91],"higher":[96,127],"dose":[97],"unchanged":[99],"less":[103,190],"pronounced":[104],"increase":[105,136,165],"content":[114],"unaffected":[116],"20-micrograms":[119],"group":[120],"but":[121],"clearly":[123],"decreased":[124],"dose.":[128],"second":[131],"statistically":[134],"significant":[135],"over":[137],"controls":[138],"found":[140],"fraction":[143],"labeled":[145],"ductal":[146,186,232],"cells":[147,195],"when":[148],"micrograms":[153],"administered.":[157],"However,":[158],"acinar":[161,184],"population":[163],"an":[164],"measured":[167],"only":[168],"160-micrograms":[171],"group.":[172],"A":[173],"tendency":[174],"to":[175],"nadir":[176],"labeling":[179],"observed":[181],"both":[183],"groups":[188],"at":[189],"stimulation.":[191],"Labeling":[192],"centroacinar":[194,234],"all":[198,205],"cerulein-treated":[199],"groups.":[200],"results":[202],"show":[203],"that":[204,223],"can":[212],"be":[213],"forced":[214],"into":[215],"proliferation":[216],"used":[221],"there":[224],"is":[225],"preferential":[226],"populations.":[236]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}