{"id":"https://openalex.org/W2059368317","doi":"https://doi.org/10.1163/156855900300109530","title":"Effects of a membrane-metallopeptidase blocking agent thiorphan in long-term cultures of human bone marrow","display_name":"Effects of a membrane-metallopeptidase blocking agent thiorphan in long-term cultures of human bone marrow","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2059368317","doi":"https://doi.org/10.1163/156855900300109530","mag":"2059368317","pmid":"https://pubmed.ncbi.nlm.nih.gov/11204028"},"language":"en","primary_location":{"id":"doi:10.1163/156855900300109530","doi":"https://doi.org/10.1163/156855900300109530","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156855900300109530","pdf_url":null,"source":{"id":"https://openalex.org/S4210178664","display_name":"Haematologia","issn_l":"0017-6559","issn":["0017-6559","1568-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320561","host_organization_name":"Brill","host_organization_lineage":["https://openalex.org/P4310320561","https://openalex.org/P4310313990"],"host_organization_lineage_names":["Brill","De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065855077","display_name":"S Janda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Silvana Stanovi\u0107 Janda","raw_affiliation_strings":["Ruder Boskovi\u0107 Institute, Department of Molecular Medicine, Zagreb, Croatia. stanovic@rudjer.irb.hr","Ruder Boskovi\u0107 Institute, Department of Molecular Medicine, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruder Boskovi\u0107 Institute, Department of Molecular Medicine, Zagreb, Croatia. stanovic@rudjer.irb.hr","institution_ids":["https://openalex.org/I4210123216"]},{"raw_affiliation_string":"Ruder Boskovi\u0107 Institute, Department of Molecular Medicine, Zagreb, Croatia","institution_ids":["https://openalex.org/I4210123216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108665715","display_name":"Igor Aurer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Aurer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089431990","display_name":"Mirna Su\u010di\u0107","orcid":"https://orcid.org/0000-0001-6918-8580","observed_orcids":["https://orcid.org/0000-0001-6918-8580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirna Su\u010di\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030904173","display_name":"Mladen Petrove\u010dki","orcid":"https://orcid.org/0000-0003-3943-0561","observed_orcids":["https://orcid.org/0000-0003-3943-0561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mladen Petrove\u010dki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112248465","display_name":"Boris Labar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris Labar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056249364","display_name":"Milivoj Borani\u0107","orcid":"https://orcid.org/0000-0003-2780-7165","observed_orcids":["https://orcid.org/0000-0003-2780-7165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milivoj Borani\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084147828","display_name":"Branka Golubi\u0107\u2010\u0106epuli\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branka Golubi\u0107-\u0106epuli\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14076596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"30","issue":"4","first_page":"289","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiorphan","display_name":"thiorphan","score":1.0},{"id":"https://openalex.org/keywords/cd10","display_name":"CD10","score":0.968999981880188},{"id":"https://openalex.org/keywords/calla","display_name":"CALLA","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.75},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/long-term-bone-marrow-culture","display_name":"long-term bone marrow culture","score":0.7310000061988831},{"id":"https://openalex.org/keywords/clonogenic-activity","display_name":"clonogenic activity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2781372283","wikidata":"https://www.wikidata.org/wiki/Q7784695","display_name":"Thiorphan","level":4,"score":0.7911925315856934},{"id":"https://openalex.org/C2993373878","wikidata":"https://www.wikidata.org/wiki/Q9621","display_name":"Human bone","level":3,"score":0.6466073393821716},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5662021636962891},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.5325037240982056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4946841895580292},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3828129172325134},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3483324646949768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2675884962081909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25294697284698486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2209492325782776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16206997632980347},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10351118445396423},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09181162714958191},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0743398368358612},{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.063172847032547},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015244","descriptor_name":"Thiorphan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1163/156855900300109530","doi":"https://doi.org/10.1163/156855900300109530","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156855900300109530","pdf_url":null,"source":{"id":"https://openalex.org/S4210178664","display_name":"Haematologia","issn_l":"0017-6559","issn":["0017-6559","1568-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320561","host_organization_name":"Brill","host_organization_lineage":["https://openalex.org/P4310320561","https://openalex.org/P4310313990"],"host_organization_lineage_names":["Brill","De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologia","raw_type":"journal-article"},{"id":"pmid:11204028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11204028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047802214","https://openalex.org/W1965236178","https://openalex.org/W2041225767","https://openalex.org/W2600323306","https://openalex.org/W2945858197","https://openalex.org/W2087074974","https://openalex.org/W2755018889","https://openalex.org/W7112413657","https://openalex.org/W3083954997","https://openalex.org/W2514437153"],"abstract_inverted_index":{"Thiorphan":[0],"[(DL-3-mercapto-2-benzylpropanoyl)-glycine],":[1],"a":[2],"drug":[3],"blocking":[4],"the":[5,25,38,42,48],"activity":[6],"of":[7,19,24,37,47],"membrane":[8],"metalloendopeptidase":[9],"EC":[10],"3.4.24.11":[11],"(CD10,":[12],"CALLA),":[13],"was":[14,27,57],"added":[15],"to":[16],"long-term":[17],"cultures":[18,26],"human":[20],"bone":[21],"marrow.":[22],"Progression":[23],"assessed":[28],"by":[29,45],"cell":[30],"counts,":[31],"cytology":[32],"and":[33,44],"clonogenic":[34],"(GM-CFU)":[35],"ability":[36],"non-adherent":[39],"cells":[40],"in":[41],"supernatant":[43],"morphology":[46],"adherent":[49],"stromal":[50],"layer.":[51],"A":[52],"stimulatory":[53],"effect":[54],"on":[55],"hematopoiesis":[56],"noted.":[58]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}