{"id":"https://openalex.org/W2059166322","doi":"https://doi.org/10.1097/00003246-197909000-00006","title":"Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values","display_name":"Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values","publication_year":1979,"publication_date":"1979-09-01","ids":{"openalex":"https://openalex.org/W2059166322","doi":"https://doi.org/10.1097/00003246-197909000-00006","mag":"2059166322","pmid":"https://pubmed.ncbi.nlm.nih.gov/111894"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-197909000-00006","doi":"https://doi.org/10.1097/00003246-197909000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-197909000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113582852","display_name":"Arthur L. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ARTHUR L. ROSEN","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111696636","display_name":"Steven A. Gould","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEVEN GOULD","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103417216","display_name":"Lakshman R. Sehgal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAKSHMAN R. SEHGAL","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067739172","display_name":"George Noud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GEORGE NOUD","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110023420","display_name":"Hansa L. Sehgal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HANSA L. SEHGAL","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066312085","display_name":"Charles L. Rice","orcid":"https://orcid.org/0000-0002-5323-6979","observed_orcids":["https://orcid.org/0000-0002-5323-6979"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLES L. RICE","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111667800","display_name":"Gerald S. Moss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GERALD S. MOSS","raw_affiliation_strings":["Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Michael Reese Hospital and the University of Chicago, and Department of Bioengineering, University of Illinois, Chicago, Il","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5904,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82587549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"9","first_page":"380","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.17640000581741333,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hemodilution","display_name":"hemodilution","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hemoglobin-solutions","display_name":"hemoglobin solutions","score":0.9309999942779541},{"id":"https://openalex.org/keywords/p50","display_name":"P50","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/exchange-transfusion","display_name":"exchange transfusion","score":0.8069999814033508},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oxyhemoglobin-dissociation-curve","display_name":"oxygen dissociation curve","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.574999988079071},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.8700000047683716},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8856871128082275},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.839942216873169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7673757076263428},{"id":"https://openalex.org/C127503593","wikidata":"https://www.wikidata.org/wiki/Q7115970","display_name":"Oxygen\u2013haemoglobin dissociation curve","level":3,"score":0.7396538853645325},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.712332010269165},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5604777336120605},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5121605396270752},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5118102431297302},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4617246985435486},{"id":"https://openalex.org/C98270193","wikidata":"https://www.wikidata.org/wiki/Q3359522","display_name":"P50","level":4,"score":0.44635850191116333},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43202149868011475},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4252781867980957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4054108262062073},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3295990526676178},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1614583432674408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09335041046142578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08188691735267639},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005078","descriptor_name":"Exchange Transfusion, Whole Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010108","descriptor_name":"Oxyhemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-197909000-00006","doi":"https://doi.org/10.1097/00003246-197909000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-197909000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:111894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/111894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1954589562","https://openalex.org/W1507878831","https://openalex.org/W2091210193","https://openalex.org/W2054221201","https://openalex.org/W2009869571","https://openalex.org/W76113500","https://openalex.org/W2194875188","https://openalex.org/W2086304349","https://openalex.org/W1988726889","https://openalex.org/W2020064961"],"abstract_inverted_index":{"Cardiovascular":[0],"responses":[1],"have":[2],"been":[3],"studied":[4],"in":[5,79,107,118],"baboons,":[6],"after":[7],"total":[8],"exchange":[9,23],"transfusion":[10],"with":[11,82],"hemoglobin":[12,31,83,111],"solutions":[13],"having":[14],"various":[15],"P50":[16,38],"values.":[17],"At":[18],"the":[19,22,25,29,37,52,73,87,90,108,119],"end":[20],"of":[21,89,110,121],"transfusion,":[24],"hematocrit":[26],"was":[27,33],"1.5%,":[28],"mean":[30],"concentration":[32],"4.4":[34],"g/dl,":[35],"and":[36,42,58,61],"varied":[39],"between":[40],"12":[41],"26":[43],"mm":[44],"Hg.":[45],"Cardiac":[46],"output":[47,81],"did":[48],"not":[49,69,95],"change":[50],"during":[51],"study,":[53],"although":[54],"heart":[55],"rate":[56],"increased,":[57],"stroke":[59],"volume":[60],"MAP":[62],"decreased.":[63],"Hemoglobin":[64],"concentration,":[65],"per":[66],"se,":[67],"does":[68,94],"appear":[70,96],"to":[71,97,105],"be":[72],"critical":[74],"stimulus":[75],"for":[76],"an":[77],"increase":[78],"cardiac":[80],"solution.":[84],"In":[85],"addition,":[86],"position":[88],"hemoglobin-oxygen":[91],"dissociation":[92],"curve":[93],"influence":[98],"these":[99],"hemodynamic":[100],"responses.":[101],"The":[102],"physiological":[103],"response":[104],"anemia":[106],"presence":[109],"solution":[112],"appears":[113],"different":[114],"from":[115],"that":[116],"observed":[117],"absence":[120],"plasma":[122],"O2":[123],"carriers.":[124]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
