{"id":"https://openalex.org/W2059160047","doi":"https://doi.org/10.1126/science.1214984","title":"SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open","display_name":"SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open","publication_year":2012,"publication_date":"2012-03-15","ids":{"openalex":"https://openalex.org/W2059160047","doi":"https://doi.org/10.1126/science.1214984","mag":"2059160047","pmid":"https://pubmed.ncbi.nlm.nih.gov/22422984","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736847"},"language":"en","primary_location":{"id":"doi:10.1126/science.1214984","doi":"https://doi.org/10.1126/science.1214984","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1214984","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024587393","display_name":"Lei Shi","orcid":"https://orcid.org/0000-0003-0752-1346","observed_orcids":["https://orcid.org/0000-0003-0752-1346","https://orcid.org/0009-0003-3088-4740"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Shi","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039450243","display_name":"Qing-Tao Shen","orcid":"https://orcid.org/0000-0003-1672-6300","observed_orcids":["https://orcid.org/0000-0003-1672-6300"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing-Tao Shen","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","2Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander Kiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kiel","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378537","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0000-0001-5412-9860"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357132","display_name":"Hongwei Wang","orcid":"https://orcid.org/0000-0001-9494-8780","observed_orcids":["https://orcid.org/0000-0001-9494-8780"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-Wei Wang","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","2Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019657763","display_name":"Thomas James Melia","orcid":"https://orcid.org/0000-0002-5798-4624","observed_orcids":["https://orcid.org/0000-0002-5798-4624"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Melia","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107942278","display_name":"James Edward Rothman","orcid":"https://orcid.org/0000-0003-4822-4161","observed_orcids":["https://orcid.org/0000-0003-4822-4161"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James E. Rothman","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045553702","display_name":"Fr\u00e9d\u00e9ric Pincet","orcid":"https://orcid.org/0000-0002-4243-2157","observed_orcids":["https://orcid.org/0000-0002-4243-2157"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Fr\u00e9d\u00e9ric Pincet","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","Laboratoire de Physique Statistique, UMR CNRS 8550 associ\u00e9e aux Universit\u00e9s Paris 6 et Paris 7, Ecole Normale Sup\u00e9rieure, 24 rue Lhomond, 75005 Paris, France","1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Laboratoire de Physique Statistique, UMR CNRS 8550 associ\u00e9e aux Universit\u00e9s Paris 6 et Paris 7, Ecole Normale Sup\u00e9rieure, 24 rue Lhomond, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241"]},{"raw_affiliation_string":"1Department of Cell Biology, School of Medicine, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045553702","https://openalex.org/A5107942278"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241","https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":9.8547,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.99212901,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"335","issue":"6074","first_page":"1355","last_page":"1359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fusion-pore","display_name":"fusion pore","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.7960000038146973},{"id":"https://openalex.org/keywords/vamp2","display_name":"VAMP2","score":0.7559999823570251},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.6039999723434448},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.6510000228881836},{"id":"https://openalex.org/keywords/pore-dilation","display_name":"pore dilation","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.7401134371757507},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.7043138742446899},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.67479008436203},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6532264947891235},{"id":"https://openalex.org/C2908790754","wikidata":"https://www.wikidata.org/wiki/Q279694","display_name":"SNARE complex","level":4,"score":0.6432347297668457},{"id":"https://openalex.org/C2780880673","wikidata":"https://www.wikidata.org/wiki/Q6964029","display_name":"Nanodisc","level":4,"score":0.6268560886383057},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5945255160331726},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.574533224105835},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.573662281036377},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5426012873649597},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5285590887069702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5052955746650696},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.4811486005783081},{"id":"https://openalex.org/C134499376","wikidata":"https://www.wikidata.org/wiki/Q14897641","display_name":"SNAP25","level":5,"score":0.4533223509788513},{"id":"https://openalex.org/C196330066","wikidata":"https://www.wikidata.org/wiki/Q7923216","display_name":"Vesicle fusion","level":5,"score":0.43704551458358765},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.41675424575805664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3807733654975891},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.37539738416671753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2504037022590637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23970025777816772},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2023705244064331},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011510","descriptor_name":"Proteolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050600","descriptor_name":"SNARE Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050600","descriptor_name":"SNARE Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050825","descriptor_name":"Synaptosomal-Associated Protein 25","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050825","descriptor_name":"Synaptosomal-Associated Protein 25","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050827","descriptor_name":"Syntaxin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050827","descriptor_name":"Syntaxin 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050988","descriptor_name":"Vesicle-Associated Membrane Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050988","descriptor_name":"Vesicle-Associated Membrane Protein 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.1214984","doi":"https://doi.org/10.1126/science.1214984","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1214984","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:22422984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22422984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2729332","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3736847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736847","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1408369","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1408369/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCIENCE , 335 (6074) pp. 1355-1359. (2012)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2729332","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3736847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5232226708","display_name":"Regulation of Membrane Fusion in Exocytosis","funder_award_id":"R01DK027044","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8438947245","display_name":"Mechanisms of Intracellular Membrane Fusion","funder_award_id":"R37DK027044","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1534237617","https://openalex.org/W1598629441","https://openalex.org/W1599906730","https://openalex.org/W1822252127","https://openalex.org/W1861338253","https://openalex.org/W1968306435","https://openalex.org/W1972675000","https://openalex.org/W1975642381","https://openalex.org/W1978916680","https://openalex.org/W1998987638","https://openalex.org/W2009685989","https://openalex.org/W2009759632","https://openalex.org/W2012668770","https://openalex.org/W2015737472","https://openalex.org/W2019594298","https://openalex.org/W2024234199","https://openalex.org/W2027775552","https://openalex.org/W2031212561","https://openalex.org/W2031949867","https://openalex.org/W2035899761","https://openalex.org/W2039794026","https://openalex.org/W2050004917","https://openalex.org/W2051103934","https://openalex.org/W2054946185","https://openalex.org/W2069500280","https://openalex.org/W2078504352","https://openalex.org/W2085680244","https://openalex.org/W2094479838","https://openalex.org/W2102074396","https://openalex.org/W2114795136","https://openalex.org/W2117213358","https://openalex.org/W2119619424","https://openalex.org/W2137639709","https://openalex.org/W2140717014","https://openalex.org/W2141704011","https://openalex.org/W2144447780","https://openalex.org/W2154100802","https://openalex.org/W2154649008"],"related_works":["https://openalex.org/W1984444179","https://openalex.org/W3123168270","https://openalex.org/W2486031807","https://openalex.org/W2599136341","https://openalex.org/W2269729153","https://openalex.org/W2902332755","https://openalex.org/W2583343198","https://openalex.org/W2203780822","https://openalex.org/W2465474420","https://openalex.org/W3004788125"],"abstract_inverted_index":{"Neurotransmitters":[0],"are":[1],"released":[2],"through":[3],"nascent":[4,119],"fusion":[5,23,36],"pores,":[6],"which":[7],"ordinarily":[8],"dilate":[9],"after":[10],"bilayer":[11,20,62],"fusion,":[12,63],"preventing":[13],"consistent":[14],"biochemical":[15],"studies.":[16],"We":[17,47,96],"used":[18],"lipid":[19],"nanodiscs":[21],"as":[22],"partners;":[24],"their":[25,103],"rigid":[26],"protein":[27,45,93],"framework":[28],"prevents":[29,117],"dilation":[30],"and":[31,85],"reveals":[32],"properties":[33],"of":[34,61,66,74,90],"the":[35,69,86,108,118],"pore":[37,120],"induced":[38],"by":[39],"SNARE":[40,53,82,104],"(soluble":[41],"N-ethylmaleimide-sensitive":[42],"factor":[43],"attachment":[44],"receptor).":[46],"found":[48],"that":[49,98,116],"although":[50],"only":[51],"one":[52],"per":[54],"nanodisc":[55],"is":[56],"required":[57],"for":[58],"maximum":[59],"rates":[60],"efficient":[64],"release":[65],"content":[67],"on":[68],"physiologically":[70],"relevant":[71],"time":[72],"scale":[73],"synaptic":[75],"transmission":[76],"apparently":[77],"requires":[78],"three":[79],"or":[80],"more":[81],"complexes":[83],"(SNAREpins)":[84],"native":[87],"transmembrane":[88,105],"domain":[89],"vesicle-associated":[91],"membrane":[92],"2":[94],"(VAMP2).":[95],"suggest":[97],"several":[99],"SNAREpins":[100],"simultaneously":[101],"zippering":[102],"helices":[106],"within":[107],"freshly":[109],"fused":[110],"bilayers":[111],"provide":[112],"a":[113],"radial":[114],"force":[115],"from":[121],"resealing":[122],"during":[123],"synchronous":[124],"neurotransmitter":[125],"release.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":31},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}