{"id":"https://openalex.org/W2059106947","doi":"https://doi.org/10.1038/nrd1152","title":"Pharmacophylogenomics: genes, evolution and drug targets","display_name":"Pharmacophylogenomics: genes, evolution and drug targets","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2059106947","doi":"https://doi.org/10.1038/nrd1152","mag":"2059106947","pmid":"https://pubmed.ncbi.nlm.nih.gov/12904811"},"language":"en","primary_location":{"id":"doi:10.1038/nrd1152","doi":"https://doi.org/10.1038/nrd1152","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrd1152","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010900550","display_name":"David B. Searls","orcid":"https://orcid.org/0000-0001-7840-8274","observed_orcids":["https://orcid.org/0000-0001-7840-8274"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David B. Searls","raw_affiliation_strings":["Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, P.O. Box 1539, King of Prussia, Pennsylvania 19406, USA. David_B_Searls@gsk.com","Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, King of Prussia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, P.O. Box 1539, King of Prussia, Pennsylvania 19406, USA. David_B_Searls@gsk.com","institution_ids":["https://openalex.org/I4210114143"]},{"raw_affiliation_string":"Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, King of Prussia, USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010900550"],"corresponding_institution_ids":["https://openalex.org/I4210114143"],"apc_list":null,"apc_paid":null,"fwci":0.7623,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.57627119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2","issue":"8","first_page":"613","last_page":"623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phylogenomics","display_name":"phylogenomics","score":0.9240000247955322},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8539999723434448},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.5059999823570251},{"id":"https://openalex.org/keywords/paralogs","display_name":"paralogs","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.656000018119812},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"protein function prediction","score":0.6800000071525574},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5329999923706055},{"id":"https://openalex.org/keywords/gene-networks","display_name":"gene networks","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C70343354","wikidata":"https://www.wikidata.org/wiki/Q3381973","display_name":"Phylogenomics","level":5,"score":0.753714919090271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5607830882072449},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5546339750289917},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5362541079521179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5362424850463867},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.47336384654045105},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.46097153425216675},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.43769556283950806},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.40278664231300354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27340027689933777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18916189670562744},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrd1152","doi":"https://doi.org/10.1038/nrd1152","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrd1152","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},{"id":"pmid:12904811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12904811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Drug discovery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W695337","https://openalex.org/W68117605","https://openalex.org/W78816759","https://openalex.org/W86501616","https://openalex.org/W178306964","https://openalex.org/W791550880","https://openalex.org/W1500396877","https://openalex.org/W1511264264","https://openalex.org/W1551836412","https://openalex.org/W1617947194","https://openalex.org/W1639854378","https://openalex.org/W1679099899","https://openalex.org/W1774748215","https://openalex.org/W1805968117","https://openalex.org/W1821582542","https://openalex.org/W1834861419","https://openalex.org/W1958476169","https://openalex.org/W1966833977","https://openalex.org/W1971449260","https://openalex.org/W1978444265","https://openalex.org/W1979558568","https://openalex.org/W1981648832","https://openalex.org/W1982663312","https://openalex.org/W1982729445","https://openalex.org/W1984765576","https://openalex.org/W1987345363","https://openalex.org/W1992625839","https://openalex.org/W1994101847","https://openalex.org/W1994261741","https://openalex.org/W1995924392","https://openalex.org/W1996874226","https://openalex.org/W1996996763","https://openalex.org/W1998777645","https://openalex.org/W2000118138","https://openalex.org/W2000253969","https://openalex.org/W2001153871","https://openalex.org/W2001580090","https://openalex.org/W2003076573","https://openalex.org/W2007215714","https://openalex.org/W2007447692","https://openalex.org/W2007513570","https://openalex.org/W2008395467","https://openalex.org/W2008900336","https://openalex.org/W2008956020","https://openalex.org/W2012185637","https://openalex.org/W2012878956","https://openalex.org/W2013340095","https://openalex.org/W2014509727","https://openalex.org/W2019672150","https://openalex.org/W2021454992","https://openalex.org/W2022488706","https://openalex.org/W2022589976","https://openalex.org/W2027957895","https://openalex.org/W2029158589","https://openalex.org/W2029353325","https://openalex.org/W2029947585","https://openalex.org/W2030640865","https://openalex.org/W2032496822","https://openalex.org/W2034568028","https://openalex.org/W2035527358","https://openalex.org/W2035611907","https://openalex.org/W2037327578","https://openalex.org/W2039263971","https://openalex.org/W2039323256","https://openalex.org/W2043648447","https://openalex.org/W2044303099","https://openalex.org/W2044305584","https://openalex.org/W2044720815","https://openalex.org/W2045040686","https://openalex.org/W2045938951","https://openalex.org/W2046564413","https://openalex.org/W2047495572","https://openalex.org/W2050214050","https://openalex.org/W2050900597","https://openalex.org/W2052262181","https://openalex.org/W2055043387","https://openalex.org/W2055097209","https://openalex.org/W2057885377","https://openalex.org/W2062220010","https://openalex.org/W2064282853","https://openalex.org/W2065172786","https://openalex.org/W2066475688","https://openalex.org/W2067007779","https://openalex.org/W2068399399","https://openalex.org/W2069420439","https://openalex.org/W2072459792","https://openalex.org/W2074370114","https://openalex.org/W2078383532","https://openalex.org/W2081614588","https://openalex.org/W2081622831","https://openalex.org/W2085808107","https://openalex.org/W2086438324","https://openalex.org/W2087892194","https://openalex.org/W2088028339","https://openalex.org/W2090663532","https://openalex.org/W2099982459","https://openalex.org/W2101963635","https://openalex.org/W2102098190","https://openalex.org/W2103320667","https://openalex.org/W2105649494","https://openalex.org/W2105865078","https://openalex.org/W2106329053","https://openalex.org/W2107251251","https://openalex.org/W2107934935","https://openalex.org/W2109650921","https://openalex.org/W2109715166","https://openalex.org/W2110705025","https://openalex.org/W2116088151","https://openalex.org/W2117436816","https://openalex.org/W2121477676","https://openalex.org/W2123411433","https://openalex.org/W2124908487","https://openalex.org/W2126541892","https://openalex.org/W2135000328","https://openalex.org/W2135123683","https://openalex.org/W2135732933","https://openalex.org/W2138024120","https://openalex.org/W2141649206","https://openalex.org/W2141864799","https://openalex.org/W2144686793","https://openalex.org/W2145250129","https://openalex.org/W2147363926","https://openalex.org/W2147659161","https://openalex.org/W2148896102","https://openalex.org/W2152529266","https://openalex.org/W2152568394","https://openalex.org/W2155238244","https://openalex.org/W2155670634","https://openalex.org/W2156346381","https://openalex.org/W2156737316","https://openalex.org/W2159266221","https://openalex.org/W2159595936","https://openalex.org/W2159596810","https://openalex.org/W2160082320","https://openalex.org/W2160667533","https://openalex.org/W2161499761","https://openalex.org/W2164034484","https://openalex.org/W2165625840","https://openalex.org/W2167015723","https://openalex.org/W2168443670","https://openalex.org/W2169929748","https://openalex.org/W2174460455","https://openalex.org/W2189322005","https://openalex.org/W2318785836","https://openalex.org/W2323638394","https://openalex.org/W2402694965","https://openalex.org/W4232581823","https://openalex.org/W4232934018","https://openalex.org/W4240629327","https://openalex.org/W4248107770","https://openalex.org/W4251304755","https://openalex.org/W4252706339","https://openalex.org/W7099253376"],"related_works":["https://openalex.org/W2158546283","https://openalex.org/W232271133","https://openalex.org/W2299787721","https://openalex.org/W2333964235","https://openalex.org/W2114676910","https://openalex.org/W4242909373","https://openalex.org/W6941552874","https://openalex.org/W4237706176","https://openalex.org/W4248056425","https://openalex.org/W2159518151"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}