{"id":"https://openalex.org/W2058993307","doi":"https://doi.org/10.1007/bf00920471","title":"Mechanisms of acute and chronic intestinal inflammation induced by indomethacin","display_name":"Mechanisms of acute and chronic intestinal inflammation induced by indomethacin","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2058993307","doi":"https://doi.org/10.1007/bf00920471","mag":"2058993307","pmid":"https://pubmed.ncbi.nlm.nih.gov/7906675"},"language":"en","primary_location":{"id":"doi:10.1007/bf00920471","doi":"https://doi.org/10.1007/bf00920471","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00920471","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013188412","display_name":"Tamaki Yamada","orcid":"https://orcid.org/0000-0002-8907-7041","observed_orcids":["https://orcid.org/0000-0002-8907-7041"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamaki Yamada","raw_affiliation_strings":["Department of Physiology, Louisiana State University Medical Center, Shreveport 71130","Departments of Physiology and Biophysics, Louisiana State University Medical Center Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Louisiana State University Medical Center, Shreveport 71130","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]},{"raw_affiliation_string":"Departments of Physiology and Biophysics, Louisiana State University Medical Center Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109833390","display_name":"Edwin A. Deitch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Deitch","raw_affiliation_strings":["Department of Surgery, Louisiana State University Medical Center, Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Louisiana State University Medical Center, Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108716265","display_name":"Robert D. Specian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Specian","raw_affiliation_strings":["Departments of Cellular Biology and Anatomy, Louisiana State University Medical Center Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular Biology and Anatomy, Louisiana State University Medical Center Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114152494","display_name":"Michael A. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael A. Perry","raw_affiliation_strings":["School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049586381","display_name":"Ryan Balfour Sartor","orcid":"https://orcid.org/0000-0002-7820-632X","observed_orcids":["https://orcid.org/0000-0002-7820-632X","https://orcid.org/0000-0002-9621-0824"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Balfour Sartor","raw_affiliation_strings":["Department of Medicine, Immunology and Microbiology Division of Digestive Disease, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Immunology and Microbiology Division of Digestive Disease, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014512255","display_name":"Matthew B. Grisham","orcid":"https://orcid.org/0000-0001-9090-721X","observed_orcids":["https://orcid.org/0000-0001-9090-721X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B. Grisham","raw_affiliation_strings":["Departments of Physiology and Biophysics, Louisiana State University Medical Center Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Biophysics, Louisiana State University Medical Center Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":5.9847,"has_fulltext":false,"cited_by_count":316,"citation_normalized_percentile":{"value":0.96978176,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"17","issue":"6","first_page":"641","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.17599999904632568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intestinal-mucosal-injury","display_name":"intestinal mucosal injury","score":0.8019999861717224},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mucosal-permeability","display_name":"mucosal permeability","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":1.0},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.41999998688697815},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7723112106323242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7158225774765015},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.6054689884185791},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.5514019727706909},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.4569443166255951},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4522165060043335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4349213242530823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4309755563735962},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42904549837112427},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4210154414176941},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36756378412246704}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00920471","doi":"https://doi.org/10.1007/bf00920471","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00920471","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},{"id":"pmid:7906675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7906675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5299999713897705},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1996376456","display_name":"INTESTINAL GOBLET CELL FUNCTION","funder_award_id":"5r01dk033720-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2641353715","display_name":"Mechanisms of Colitis Induced by Defined Bacterial Flora","funder_award_id":"R01DK040249","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3636739463","display_name":null,"funder_award_id":"DK 40249","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4316052840","display_name":null,"funder_award_id":"DK-33720","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4733363870","display_name":"Role of the Microcirculation in Intestinal Inflammation","funder_award_id":"P01DK043785","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G663048502","display_name":null,"funder_award_id":"DK-43785","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W199013364","https://openalex.org/W1597502489","https://openalex.org/W1606919860","https://openalex.org/W1632750319","https://openalex.org/W1710496838","https://openalex.org/W1786438081","https://openalex.org/W1796692248","https://openalex.org/W1815207518","https://openalex.org/W1820708208","https://openalex.org/W1896600727","https://openalex.org/W1947012729","https://openalex.org/W1982769345","https://openalex.org/W2011666294","https://openalex.org/W2014753452","https://openalex.org/W2039784446","https://openalex.org/W2045543605","https://openalex.org/W2047230911","https://openalex.org/W2052022810","https://openalex.org/W2059605635","https://openalex.org/W2087718898","https://openalex.org/W2095003217","https://openalex.org/W2113157633","https://openalex.org/W2123517269","https://openalex.org/W2130643330","https://openalex.org/W2136419595","https://openalex.org/W2160928363","https://openalex.org/W2163091610","https://openalex.org/W2169713006","https://openalex.org/W2177774817","https://openalex.org/W2182324525","https://openalex.org/W2205113102","https://openalex.org/W2266271079","https://openalex.org/W2266742768","https://openalex.org/W2281535589","https://openalex.org/W2317311329","https://openalex.org/W2417586332"],"related_works":["https://openalex.org/W1963756759","https://openalex.org/W2014753452","https://openalex.org/W2233465375","https://openalex.org/W38970891","https://openalex.org/W2017993988","https://openalex.org/W2034194966","https://openalex.org/W2016325531","https://openalex.org/W2160306898","https://openalex.org/W1982906656","https://openalex.org/W2169713006"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}