{"id":"https://openalex.org/W2058970657","doi":"https://doi.org/10.3390/ph5091008","title":"Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer","display_name":"Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer","publication_year":2012,"publication_date":"2012-09-12","ids":{"openalex":"https://openalex.org/W2058970657","doi":"https://doi.org/10.3390/ph5091008","mag":"2058970657","pmid":"https://pubmed.ncbi.nlm.nih.gov/24280702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3816649"},"language":"en","primary_location":{"id":"doi:10.3390/ph5091008","doi":"https://doi.org/10.3390/ph5091008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph5091008","pdf_url":"https://www.mdpi.com/1424-8247/5/9/1008/pdf?version=1347460030","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/5/9/1008/pdf?version=1347460030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046758725","display_name":"Flora Zagouri","orcid":"https://orcid.org/0000-0001-7153-6556","observed_orcids":["https://orcid.org/0000-0001-7153-6556"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Flora Zagouri","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029860089","display_name":"Evangelos Bournakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelos Bournakis","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066877181","display_name":"Konstantinos Koutsoukos","orcid":"https://orcid.org/0000-0002-1710-125X","observed_orcids":["https://orcid.org/0000-0002-1710-125X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Koutsoukos","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056643910","display_name":"CHRISTOS A. PAPADIMITRIOU","orcid":"https://orcid.org/0000-0001-8084-0445","observed_orcids":["https://orcid.org/0000-0001-8084-0445"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos A. Papadimitriou","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 80 Vas. Sofias Ave, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046758725"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.9443,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.69780757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"9","first_page":"1008","last_page":"1020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8690000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/geldanamycin","display_name":"geldanamycin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"ductal carcinoma","score":0.699999988079071},{"id":"https://openalex.org/keywords/lobular-carcinoma","display_name":"lobular carcinoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6710000038146973},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9409999847412109},{"id":"https://openalex.org/keywords/erbb-receptor-tyrosine-kinases","display_name":"ErbB receptor tyrosine kinases","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/nvp-auy922","display_name":"NVP-AUY922","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.8016692399978638},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6925351619720459},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6809192299842834},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5745458602905273},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5714835524559021},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.5529942512512207},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4959350526332855},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48668891191482544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48472926020622253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4637020230293274},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4321558475494385},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4135759174823761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3782458007335663},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24844014644622803},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24728524684906006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.241327166557312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1403806507587433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07020255923271179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/ph5091008","doi":"https://doi.org/10.3390/ph5091008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph5091008","pdf_url":"https://www.mdpi.com/1424-8247/5/9/1008/pdf?version=1347460030","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2812410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3816649","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24280702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24280702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3816649","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3816649/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.814.5182","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.814.5182","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/44/7b/pharmaceuticals-05-01008.PMC3816649.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0b90189e63334c3383d3e74bbb80f3ee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0b90189e63334c3383d3e74bbb80f3ee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 5, Iss 9, Pp 1008-1020 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph5091008","doi":"https://doi.org/10.3390/ph5091008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph5091008","pdf_url":"https://www.mdpi.com/1424-8247/5/9/1008/pdf?version=1347460030","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326375","display_name":"Hellenic Society of Medical Oncology","ror":"https://ror.org/02ar9bs92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058970657.pdf","grobid_xml":"https://content.openalex.org/works/W2058970657.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1584143182","https://openalex.org/W1861588860","https://openalex.org/W1965338159","https://openalex.org/W1969735755","https://openalex.org/W1970081412","https://openalex.org/W1970392870","https://openalex.org/W1970700441","https://openalex.org/W1975354656","https://openalex.org/W1987253577","https://openalex.org/W1988675578","https://openalex.org/W1989350070","https://openalex.org/W1993481510","https://openalex.org/W2001215449","https://openalex.org/W2002878333","https://openalex.org/W2005131012","https://openalex.org/W2006148642","https://openalex.org/W2011952211","https://openalex.org/W2014514145","https://openalex.org/W2016949830","https://openalex.org/W2016976719","https://openalex.org/W2017399352","https://openalex.org/W2021593763","https://openalex.org/W2021780216","https://openalex.org/W2021970375","https://openalex.org/W2028978816","https://openalex.org/W2030392116","https://openalex.org/W2033620285","https://openalex.org/W2035428017","https://openalex.org/W2036091065","https://openalex.org/W2038441129","https://openalex.org/W2042985720","https://openalex.org/W2046329541","https://openalex.org/W2047367472","https://openalex.org/W2047782251","https://openalex.org/W2051291394","https://openalex.org/W2052701304","https://openalex.org/W2056693633","https://openalex.org/W2060902443","https://openalex.org/W2070788764","https://openalex.org/W2071057846","https://openalex.org/W2072189442","https://openalex.org/W2075655675","https://openalex.org/W2077244922","https://openalex.org/W2077785228","https://openalex.org/W2080384696","https://openalex.org/W2080607777","https://openalex.org/W2082581177","https://openalex.org/W2084545157","https://openalex.org/W2087689873","https://openalex.org/W2092477354","https://openalex.org/W2096491522","https://openalex.org/W2099546104","https://openalex.org/W2100881236","https://openalex.org/W2108255072","https://openalex.org/W2112133866","https://openalex.org/W2116082448","https://openalex.org/W2116393881","https://openalex.org/W2118136186","https://openalex.org/W2124018299","https://openalex.org/W2124705172","https://openalex.org/W2131384028","https://openalex.org/W2137417707","https://openalex.org/W2137603765","https://openalex.org/W2139306838","https://openalex.org/W2140591508","https://openalex.org/W2145760315","https://openalex.org/W2147891181","https://openalex.org/W2154483009","https://openalex.org/W2154762345","https://openalex.org/W2157360354","https://openalex.org/W2158003079","https://openalex.org/W2158294714","https://openalex.org/W2158780525","https://openalex.org/W2166051550","https://openalex.org/W2166999544","https://openalex.org/W2169402489","https://openalex.org/W2171243763","https://openalex.org/W2171708713","https://openalex.org/W2176761132","https://openalex.org/W2510726666","https://openalex.org/W2608585668","https://openalex.org/W2911920126","https://openalex.org/W4285719527","https://openalex.org/W6634821297","https://openalex.org/W6675065306","https://openalex.org/W6682968727"],"related_works":["https://openalex.org/W1859918890","https://openalex.org/W7096335980","https://openalex.org/W2006148642","https://openalex.org/W2158003079","https://openalex.org/W581707937","https://openalex.org/W2029243355","https://openalex.org/W7133429972","https://openalex.org/W2090758787","https://openalex.org/W2794088236","https://openalex.org/W2996635613"],"abstract_inverted_index":{"Hsp90":[0,74,96,108,149,172],"is":[1,146],"an":[2],"abundant":[3],"protein":[4,21,27],"in":[5,42,79,101,139,156,163],"mammalian":[6],"cells.":[7],"It":[8,31],"forms":[9],"several":[10],"discrete":[11],"complexes,":[12],"each":[13],"containing":[14],"distinct":[15],"groups":[16],"of":[17,36,65,69,88,116,133,142],"co-chaperones":[18],"that":[19,38,151],"assist":[20],"folding":[22],"and":[23,29,62,105],"refolding":[24],"during":[25],"stress,":[26],"transport":[28],"degradation.":[30],"interacts":[32],"with":[33,165],"a":[34,63,93,114,117],"variety":[35,64],"proteins":[37],"play":[39],"key":[40],"roles":[41],"breast":[43,80,89,121,168],"neoplasia":[44],"including":[45],"estrogen":[46],"receptors,":[47],"tumor":[48],"suppressor":[49],"p53":[50],"protein,":[51],"angiogenesis":[52],"transcription":[53],"factor":[54],"HIF-1alpha,":[55],"antiapoptotic":[56],"kinase":[57,61],"Akt,":[58],"Raf-1":[59],"MAP":[60],"receptor":[66],"tyrosine":[67],"kinases":[68],"the":[70,85,140,147],"erbB":[71],"family.":[72],"Elevated":[73],"expression":[75,97],"has":[76,98,110,152],"been":[77,99,111,154],"documented":[78],"ductal":[81],"carcinomas":[82,104],"contributing":[83],"to":[84,126],"proliferative":[86],"activity":[87],"cancer":[90,122,143],"cells;":[91],"whilst":[92,170],"significantly":[94],"decreased":[95],"shown":[100],"infiltrative":[102],"lobular":[103,106],"neoplasia.":[107],"overexpression":[109],"proposed":[112],"as":[113],"component":[115],"mechanism":[118],"through":[119],"which":[120],"cells":[123],"become":[124],"resistant":[125],"various":[127],"stress":[128],"stimuli.":[129],"Therefore,":[130],"pharmacological":[131],"inhibition":[132],"HSPs":[134],"can":[135],"provide":[136],"therapeutic":[137],"opportunities":[138],"field":[141],"treatment.":[144],"17-allylamino,17-demethoxygeldanamycin":[145],"first":[148],"inhibitor":[150],"clinically":[153],"investigated":[155],"phase":[157],"II":[158],"trial,":[159],"yielding":[160],"promising":[161],"results":[162],"patients":[164],"HER2-overexpressing":[166],"metastatic":[167],"cancer,":[169],"other":[171],"inhibitors":[173],"(retaspimycin":[174],"HCL,":[175],"NVP-AUY922,":[176],"NVP-BEP800,":[177],"CNF2024/BIIB021,":[178],"SNX-5422,":[179],"STA-9090,":[180],"etc.)":[181],"are":[182],"currently":[183],"under":[184],"evaluation.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
