{"id":"https://openalex.org/W2058909615","doi":"https://doi.org/10.1097/shk.0b013e31817048f7","title":"CYCLOOXYGENASE 2 PATHWAY AND ITS THERAPEUTIC INHIBITION IN SUPERANTIGEN-INDUCED TOXIC SHOCK","display_name":"CYCLOOXYGENASE 2 PATHWAY AND ITS THERAPEUTIC INHIBITION IN SUPERANTIGEN-INDUCED TOXIC SHOCK","publication_year":2008,"publication_date":"2008-11-11","ids":{"openalex":"https://openalex.org/W2058909615","doi":"https://doi.org/10.1097/shk.0b013e31817048f7","mag":"2058909615","pmid":"https://pubmed.ncbi.nlm.nih.gov/18496243"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0b013e31817048f7","doi":"https://doi.org/10.1097/shk.0b013e31817048f7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e31817048f7","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104490805","display_name":"Govindarajan Rajagopalan","orcid":"https://orcid.org/0000-0003-4914-8746","observed_orcids":["https://orcid.org/0000-0003-4914-8746","https://orcid.org/0000-0003-2608-8162"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Govindarajan Rajagopalan","raw_affiliation_strings":["Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. rajagopalan.govindarajan@mayo.edu","Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. rajagopalan.govindarajan@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022178171","display_name":"Yan W. Asmann","orcid":"https://orcid.org/0000-0002-8896-2647","observed_orcids":["https://orcid.org/0000-0002-8896-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan W. Asmann","raw_affiliation_strings":["Bioinformatics Support Core, Division of Biomedical Informatics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Support Core, Division of Biomedical Informatics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091119450","display_name":"Anna K. Lytle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna K. Lytle","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067288426","display_name":"Ashenafi Y. Tilahun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ashenafi Y. Tilahun","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039729230","display_name":"Jayne E. Theuer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jayne E. Theuer","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103535416","display_name":"Michele K. Smart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michele K. Smart","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067156920","display_name":"Robin Patel","orcid":"https://orcid.org/0000-0001-6344-4141","observed_orcids":["https://orcid.org/0000-0001-6344-4141"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Patel","raw_affiliation_strings":["Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109087051","display_name":"Chella S. David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chella S. David","raw_affiliation_strings":["Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039729230","https://openalex.org/A5067288426","https://openalex.org/A5091119450","https://openalex.org/A5103535416","https://openalex.org/A5104490805","https://openalex.org/A5109087051"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.9349,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74964772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"6","first_page":"721","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxic-shock-syndrome","display_name":"toxic shock syndrome","score":0.8220000267028809},{"id":"https://openalex.org/keywords/superantigens","display_name":"superantigens","score":0.9169999957084656},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-b","display_name":"staphylococcal enterotoxin B","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/eicosanoid-pathway","display_name":"eicosanoid pathway","score":0.8939999938011169},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6549999713897705},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7919999957084656},{"id":"https://openalex.org/keywords/thymocyte-apoptosis","display_name":"thymocyte apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/bioterrorism-agents","display_name":"bioterrorism agents","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.9671655893325806},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5565763115882874},{"id":"https://openalex.org/C2779821349","wikidata":"https://www.wikidata.org/wiki/Q1128440","display_name":"Toxic shock syndrome","level":4,"score":0.5160007476806641},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43752917647361755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4332781136035919},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4209473133087158},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3898268938064575},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3216424882411957},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.13478747010231018},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/shk.0b013e31817048f7","doi":"https://doi.org/10.1097/shk.0b013e31817048f7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e31817048f7","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:18496243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18496243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6243250299","display_name":"HLA class II transgenic mouse models for S. aureus infections and superantigens","funder_award_id":"R01AI068741","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1521499119","https://openalex.org/W1534409678","https://openalex.org/W1539392991","https://openalex.org/W1608768669","https://openalex.org/W1768137357","https://openalex.org/W1967031534","https://openalex.org/W1972416794","https://openalex.org/W1976053940","https://openalex.org/W1983229673","https://openalex.org/W1983846118","https://openalex.org/W1990778416","https://openalex.org/W2003359862","https://openalex.org/W2009091144","https://openalex.org/W2010720008","https://openalex.org/W2019327411","https://openalex.org/W2032890559","https://openalex.org/W2037991981","https://openalex.org/W2039739577","https://openalex.org/W2042397891","https://openalex.org/W2043688330","https://openalex.org/W2062938379","https://openalex.org/W2065001772","https://openalex.org/W2067125561","https://openalex.org/W2068044231","https://openalex.org/W2072696221","https://openalex.org/W2073202677","https://openalex.org/W2077944937","https://openalex.org/W2082936029","https://openalex.org/W2084224278","https://openalex.org/W2106323366","https://openalex.org/W2108819945","https://openalex.org/W2111762914","https://openalex.org/W2115507879","https://openalex.org/W2126043069","https://openalex.org/W2128515425","https://openalex.org/W2129959902","https://openalex.org/W2131272563","https://openalex.org/W2133732201","https://openalex.org/W2137179791","https://openalex.org/W2137918904","https://openalex.org/W2138975629","https://openalex.org/W2141869563","https://openalex.org/W2143378100","https://openalex.org/W2145825115","https://openalex.org/W2150451033","https://openalex.org/W2151340873","https://openalex.org/W3188209924","https://openalex.org/W4297085868","https://openalex.org/W6666107276"],"related_works":["https://openalex.org/W2982170351","https://openalex.org/W1967005844","https://openalex.org/W2127161843","https://openalex.org/W1922711553","https://openalex.org/W2272152428","https://openalex.org/W2252849991","https://openalex.org/W2058604910","https://openalex.org/W2171567992","https://openalex.org/W2003633341","https://openalex.org/W2045941058"],"abstract_inverted_index":{"Bacterial":[0],"superantigens":[1,24,66],"are":[2,8,79],"a":[3,29,191],"family":[4],"of":[5,16,31,54,83,90,92,108,127,157,177,188,205,215],"exotoxins":[6],"that":[7,202],"the":[9,47,57,84,105,112,175,178],"most":[10],"potent":[11],"T-cell":[12,63,227],"activators":[13],"known.":[14],"Because":[15],"their":[17],"ability":[18],"to":[19,38,49,68,219],"induce":[20],"strong":[21],"immune":[22],"activation,":[23],"have":[25,46],"been":[26],"implicated":[27],"in":[28,88,181,222],"variety":[30],"diseases":[32],"ranging":[33],"from":[34],"self-limiting":[35],"food":[36],"poisoning":[37],"more":[39],"severe":[40],"toxic":[41],"shock":[42],"syndrome":[43],"(TSS)":[44],"and":[45,76,229],"potential":[48],"be":[50,197],"used":[51],"as":[52,169],"agents":[53],"bioterrorism.":[55],"Nonetheless,":[56],"precise":[58],"molecular":[59,106],"mechanisms":[60],"by":[61,65,120,141,167,171,190],"which":[62],"activation":[64],"lead":[67],"acute":[69],"systemic":[70,147],"inflammatory":[71],"response,":[72],"multiple":[73],"organ":[74],"dysfunction,":[75],"ultimately":[77],"death":[78],"unclear.":[80],"Inadequate":[81],"understanding":[82],"pathogenesis":[85,107],"has":[86],"resulted":[87],"lack":[89],"development":[91],"effective":[93],"therapy":[94],"for":[95],"superantigen-induced":[96,109],"TSS.":[97],"To":[98],"fill":[99],"these":[100],"deficiencies,":[101],"we":[102,183],"systematically":[103],"dissected":[104],"TSS":[110],"using":[111],"humanized":[113],"human":[114],"leukocyte":[115],"antigen-DR3":[116],"transgenic":[117],"mouse":[118],"model":[119],"microarray-based":[121],"gene":[122,138],"expression":[123,126],"profiling.":[124],"Splenic":[125],"prostaglandin-endoperoxide":[128],"synthase":[129],"2":[130,135],"(PTGS-2;":[131],"also":[132],"called":[133],"cyclooxygenase":[134],"or":[136,226],"COX-2)":[137],"was":[139,217],"increased":[140],"several":[142,158],"hundred":[143],"folds":[144],"shortly":[145],"after":[146,210],"superantigen":[148],"(staphylococcal":[149],"enterotoxin":[150],"B":[151],"[SEB])":[152],"exposure.":[153],"In":[154],"addition,":[155],"expressions":[156],"genes":[159],"associated":[160],"with":[161,212],"eicosanoid":[162],"pathway":[163,180],"were":[164],"significantly":[165],"modulated":[166],"SEB,":[168],"analyzed":[170],"dedicated":[172],"software.":[173],"Given":[174],"importance":[176],"COX-2":[179,189],"inflammation,":[182],"examined":[184],"whether":[185],"therapeutic":[186],"inhibition":[187],"highly":[192],"selective":[193],"inhibitor,":[194],"CAY10404,":[195],"could":[196],"beneficial.":[198],"Our":[199],"studies":[200],"showed":[201],"i.p.":[203],"administration":[204],"CAY10404":[206],"(50":[207],"mg/kg)":[208],"immediately":[209],"challenge":[211],"10":[213],"microg":[214],"SEB":[216],"unable":[218],"inhibit":[220],"SEB-induced":[221],"vivo":[223],"cytokine/chemokine":[224],"production":[225],"activation/proliferation":[228],"did":[230],"not":[231],"prevent":[232],"superantigen-associated":[233],"thymocyte":[234],"apoptosis.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
