{"id":"https://openalex.org/W2058838014","doi":"https://doi.org/10.4155/cli.12.124","title":"The risks and benefits of prophylactic aspirin in vascular disease and cancer","display_name":"The risks and benefits of prophylactic aspirin in vascular disease and cancer","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2058838014","doi":"https://doi.org/10.4155/cli.12.124","mag":"2058838014"},"language":"en","primary_location":{"id":"doi:10.4155/cli.12.124","doi":"https://doi.org/10.4155/cli.12.124","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.12.124","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065614621","display_name":"P C Elwood","orcid":"https://orcid.org/0000-0003-4352-1570","observed_orcids":["https://orcid.org/0000-0003-4352-1570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C Elwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammed Mustafa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Mustafa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058078331","display_name":"Maribel Almonte","orcid":"https://orcid.org/0000-0003-1623-8323","observed_orcids":["https://orcid.org/0000-0003-1623-8323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maribel Almonte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102849724","display_name":"Gareth Morgan","orcid":"https://orcid.org/0000-0003-0429-6294","observed_orcids":["https://orcid.org/0000-0003-0429-6294","https://orcid.org/0000-0001-7884-1131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4116,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70878245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"12","first_page":"1177","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.6399999856948853},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.9729999899864197},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cancer-risk-reduction","display_name":"cancer risk reduction","score":0.7570000290870667},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cerebral-hemorrhage","display_name":"cerebral hemorrhage","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7390000224113464},{"id":"https://openalex.org/keywords/risks-and-benefits","display_name":"benefits and risks","score":0.9269999861717224},{"id":"https://openalex.org/keywords/public-health-recommendations","display_name":"public health recommendations","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9183887243270874},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.7817028760910034},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5700948238372803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4831823408603668},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4334401786327362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2589470148086548}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4155/cli.12.124","doi":"https://doi.org/10.4155/cli.12.124","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.12.124","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1500319461","https://openalex.org/W1543891416","https://openalex.org/W1556659072","https://openalex.org/W1630039729","https://openalex.org/W1735640395","https://openalex.org/W1965700064","https://openalex.org/W1969956137","https://openalex.org/W1972842820","https://openalex.org/W1974742589","https://openalex.org/W1974851196","https://openalex.org/W1986422577","https://openalex.org/W1986792617","https://openalex.org/W1987244386","https://openalex.org/W1991449500","https://openalex.org/W1995252424","https://openalex.org/W1998082977","https://openalex.org/W2005903558","https://openalex.org/W2005971868","https://openalex.org/W2010903227","https://openalex.org/W2024352468","https://openalex.org/W2025287865","https://openalex.org/W2033644031","https://openalex.org/W2035159045","https://openalex.org/W2036990165","https://openalex.org/W2037460050","https://openalex.org/W2037681348","https://openalex.org/W2042892005","https://openalex.org/W2043515240","https://openalex.org/W2048554273","https://openalex.org/W2055808034","https://openalex.org/W2061544195","https://openalex.org/W2067377514","https://openalex.org/W2068479098","https://openalex.org/W2068978328","https://openalex.org/W2085615121","https://openalex.org/W2094870097","https://openalex.org/W2096851332","https://openalex.org/W2100089051","https://openalex.org/W2102937816","https://openalex.org/W2109283444","https://openalex.org/W2111175587","https://openalex.org/W2114120215","https://openalex.org/W2116051185","https://openalex.org/W2117459641","https://openalex.org/W2120027412","https://openalex.org/W2121348098","https://openalex.org/W2123533317","https://openalex.org/W2123973590","https://openalex.org/W2126477578","https://openalex.org/W2137408480","https://openalex.org/W2138354297","https://openalex.org/W2145218953","https://openalex.org/W2146172573","https://openalex.org/W2146233513","https://openalex.org/W2146991873","https://openalex.org/W2147579615","https://openalex.org/W2151036184","https://openalex.org/W2151840649","https://openalex.org/W2152352298","https://openalex.org/W2152505303","https://openalex.org/W2153728095","https://openalex.org/W2157304020","https://openalex.org/W2161254333","https://openalex.org/W2168981163","https://openalex.org/W2170932503","https://openalex.org/W2171061276","https://openalex.org/W2188507800","https://openalex.org/W2318925269","https://openalex.org/W2320901702","https://openalex.org/W2321365042","https://openalex.org/W2321390295","https://openalex.org/W2409789556","https://openalex.org/W2548638712","https://openalex.org/W2567070649","https://openalex.org/W2760117593","https://openalex.org/W4239888262"],"related_works":["https://openalex.org/W2168926300","https://openalex.org/W1977223204","https://openalex.org/W1982898414","https://openalex.org/W3125694305","https://openalex.org/W2118928861","https://openalex.org/W2099841967","https://openalex.org/W2970015907","https://openalex.org/W7064241935","https://openalex.org/W2387727724","https://openalex.org/W2620767117"],"abstract_inverted_index":{"Substantial":[0],"evidence":[1,28,86],"from":[2,7,29,57,111],"randomized":[3],"trials":[4],"confirms":[5],"benefit":[6],"aspirin":[8,47,62,74,109,131,141],"in":[9,23,39,93,103,119,124],"the":[10,70,77,94,105,148],"secondary":[11],"reduction":[12,38],"of":[13,46,96,108,116],"vascular":[14,120],"disease":[15,121],"but":[16,84],"there":[17],"is":[18,81,100,132],"debate":[19],"about":[20,140],"its":[21],"use":[22],"primary":[24],"prevention.":[25],"More":[26],"recently,":[27],"long-term":[30],"follow":[31],"up":[32],"and":[33,123,134,137],"other":[34],"studies":[35],"indicates":[36],"a":[37,112],"cancer":[40,125],"by":[41,73],"aspirin.":[42],"The":[43],"undesirable":[44],"effects":[45],"include":[48],"gastrointestinal":[49,58],"bleeding":[50,59],"and,":[51],"rarely,":[52],"cerebral":[53,88],"bleeding.":[54],"However,":[55],"deaths":[56],"attributable":[60],"to":[61,65,145],"appear":[63],"not":[64,76,135],"be":[66,143],"increased,":[67],"suggesting":[68],"that":[69,87,102],"bleeds":[71,89],"provoked":[72],"are":[75,126],"most":[78],"serious.":[79],"There":[80],"also":[82],"suggestive,":[83],"limited,":[85],"may":[90],"occur":[91],"only":[92],"presence":[95],"uncontrolled":[97],"hypertension.":[98],"It":[99],"important":[101],"considering":[104],"risk\u2013benefit":[106],"balance":[107],"prophylaxis":[110,133],"public":[113],"health":[114],"point":[115],"view,":[117],"reductions":[118],"events":[122],"considered":[127],"together.":[128],"Furthermore,":[129],"low-dose":[130],"treatment,":[136],"so":[138],"advice":[139],"should":[142],"given":[144],"subjects":[146],"within":[147],"...":[149]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}
