{"id":"https://openalex.org/W2058772405","doi":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","title":"Pulmonary arterial hypertension: New insights and new hope","display_name":"Pulmonary arterial hypertension: New insights and new hope","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2058772405","doi":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","mag":"2058772405","pmid":"https://pubmed.ncbi.nlm.nih.gov/16423196"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1843.2006.00778.x","doi":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1843.2006.00778.x","source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1843.2006.00778.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062800037","display_name":"Kevin Braun Martin","orcid":"https://orcid.org/0000-0001-7915-6515","observed_orcids":["https://orcid.org/0000-0001-7915-6515"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin B. MARTIN","raw_affiliation_strings":["Pulmonary & Critical Care, Department of Medicine, Brown Medical School, Providence VA Medical Center, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary & Critical Care, Department of Medicine, Brown Medical School, Providence VA Medical Center, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071223454","display_name":"James R. Klinger","orcid":"https://orcid.org/0000-0003-2997-5955","observed_orcids":["https://orcid.org/0000-0003-2997-5955"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. KLINGER","raw_affiliation_strings":["The Rhode Island Hospital, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rhode Island Hospital, Providence, RI, USA","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052093274","display_name":"Sharon Rounds","orcid":"https://orcid.org/0000-0002-5008-616X","observed_orcids":["https://orcid.org/0000-0002-5008-616X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sharon I. S. ROUNDS","raw_affiliation_strings":["Pulmonary & Critical Care, Department of Medicine, Brown Medical School, Providence VA Medical Center and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary & Critical Care, Department of Medicine, Brown Medical School, Providence VA Medical Center and","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052093274"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":1.4594,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.79555809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"6","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":1.0},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.949999988079071},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-basis","display_name":"genetic basis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pah-therapy","display_name":"PAH therapy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/serotonin-transporter-inhibitors","display_name":"serotonin transporter inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dichloroacetate","display_name":"dichloroacetate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.9819999933242798},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.9100000262260437},{"id":"https://openalex.org/keywords/antiproliferative-therapy","display_name":"antiproliferative therapy","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8950037360191345},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6678667068481445},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.5897347927093506},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5720874071121216},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.46187281608581543},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4176708459854126},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.41571030020713806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3567020297050476},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3566996157169342},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3548617959022522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003999","descriptor_name":"Dichloroacetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003999","descriptor_name":"Dichloroacetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1843.2006.00778.x","doi":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1843.2006.00778.x","source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},{"id":"pmid:16423196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16423196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology (Carlton, Vic.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1440-1843.2006.00778.x","doi":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2006.00778.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1843.2006.00778.x","source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058772405.pdf","grobid_xml":"https://content.openalex.org/works/W2058772405.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W59441890","https://openalex.org/W177395109","https://openalex.org/W1758605856","https://openalex.org/W1822055970","https://openalex.org/W1840736932","https://openalex.org/W1868661801","https://openalex.org/W1876864122","https://openalex.org/W1916790479","https://openalex.org/W1919041450","https://openalex.org/W1927797304","https://openalex.org/W1965418020","https://openalex.org/W1973664081","https://openalex.org/W1974227996","https://openalex.org/W1980619986","https://openalex.org/W1987425562","https://openalex.org/W1989930057","https://openalex.org/W1994148625","https://openalex.org/W1994219663","https://openalex.org/W1996588278","https://openalex.org/W2004127755","https://openalex.org/W2005339350","https://openalex.org/W2011985298","https://openalex.org/W2012400171","https://openalex.org/W2015390870","https://openalex.org/W2017909256","https://openalex.org/W2019925583","https://openalex.org/W2023167197","https://openalex.org/W2024743180","https://openalex.org/W2030357540","https://openalex.org/W2035427061","https://openalex.org/W2036100871","https://openalex.org/W2037502378","https://openalex.org/W2039518943","https://openalex.org/W2039765797","https://openalex.org/W2040336481","https://openalex.org/W2041234387","https://openalex.org/W2043030209","https://openalex.org/W2044534634","https://openalex.org/W2048443661","https://openalex.org/W2056966654","https://openalex.org/W2069002270","https://openalex.org/W2075764782","https://openalex.org/W2076249017","https://openalex.org/W2084140785","https://openalex.org/W2090213540","https://openalex.org/W2095255029","https://openalex.org/W2095734666","https://openalex.org/W2096393477","https://openalex.org/W2098946775","https://openalex.org/W2101768152","https://openalex.org/W2106095564","https://openalex.org/W2106319447","https://openalex.org/W2108920343","https://openalex.org/W2109779629","https://openalex.org/W2111274165","https://openalex.org/W2113179574","https://openalex.org/W2113554645","https://openalex.org/W2114601292","https://openalex.org/W2116020190","https://openalex.org/W2119233090","https://openalex.org/W2121688503","https://openalex.org/W2131364104","https://openalex.org/W2131726013","https://openalex.org/W2133447422","https://openalex.org/W2139960175","https://openalex.org/W2140148084","https://openalex.org/W2141987653","https://openalex.org/W2147750581","https://openalex.org/W2149279554","https://openalex.org/W2149688277","https://openalex.org/W2150989458","https://openalex.org/W2151978982","https://openalex.org/W2152323385","https://openalex.org/W2152907844","https://openalex.org/W2153625446","https://openalex.org/W2158657788","https://openalex.org/W2162125686","https://openalex.org/W2162720389","https://openalex.org/W2162804111","https://openalex.org/W2166049758","https://openalex.org/W2166985476","https://openalex.org/W2188364927","https://openalex.org/W2191613235","https://openalex.org/W2313098007","https://openalex.org/W2313158847","https://openalex.org/W2321522617","https://openalex.org/W2326860105","https://openalex.org/W2329065056","https://openalex.org/W2331798828","https://openalex.org/W2411779599","https://openalex.org/W2418761934","https://openalex.org/W2419424321","https://openalex.org/W2473762969","https://openalex.org/W2508515774","https://openalex.org/W3023130045"],"related_works":["https://openalex.org/W826142185","https://openalex.org/W2138428172","https://openalex.org/W2142911045","https://openalex.org/W4327959658","https://openalex.org/W3176971138","https://openalex.org/W2018066429","https://openalex.org/W4303961764","https://openalex.org/W4362523151","https://openalex.org/W2273556577","https://openalex.org/W1988859466"],"abstract_inverted_index":{"Pulmonary":[0],"arterial":[1,78],"hypertension":[2],"(PAH)":[3],"is":[4,35],"a":[5],"devastating":[6],"disorder":[7],"characterized":[8],"by":[9,90,95,102],"abnormal":[10],"increased":[11],"vasoconstriction":[12],"and":[13,25,43,66,75,100],"vascular":[14],"remodelling.":[15],"In":[16],"this":[17,29],"review":[18,45],"we":[19,44],"discuss":[20,57],"the":[21,51,54],"pathophysiology,":[22],"genetic":[23],"basis":[24],"clinical":[26],"features":[27],"of":[28,33,40,53,105],"disorder.":[30],"Current":[31],"therapy":[32],"PAH":[34],"based":[36,49],"on":[37,50],"an":[38],"understanding":[39],"its":[41],"pathogenesis,":[42],"current":[46],"treatment":[47],"options":[48],"pathophysiology":[52],"disease.":[55],"We":[56],"three":[58,70],"promising":[59],"novel":[60],"therapies":[61,71],"studied":[62],"in":[63],"animal":[64],"models":[65],"human":[67],"tissue.":[68],"All":[69],"appear":[72],"to":[73],"prevent":[74],"reduce":[76],"pulmonary":[77],"medial":[79],"hyperplasia":[80],"through":[81],"their":[82],"anti-proliferative":[83],"and/or":[84],"pro-apoptotic":[85],"effects:":[86],"serotonin":[87,92],"transporter":[88],"inhibitors":[89],"blocking":[91],"uptake;":[93],"dichloroacetate":[94],"activating":[96],"voltage-gated":[97],"potassium":[98],"channels;":[99],"simvastatin":[101],"preventing":[103],"activation":[104],"small":[106],"GTPases.":[107]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}