{"id":"https://openalex.org/W2058747461","doi":"https://doi.org/10.1002/hep.24037","title":"Effect of sorafenib on murine liver regeneration","display_name":"Effect of sorafenib on murine liver regeneration","publication_year":2010,"publication_date":"2010-10-11","ids":{"openalex":"https://openalex.org/W2058747461","doi":"https://doi.org/10.1002/hep.24037","mag":"2058747461","pmid":"https://pubmed.ncbi.nlm.nih.gov/21274878"},"language":"en","primary_location":{"id":"doi:10.1002/hep.24037","doi":"https://doi.org/10.1002/hep.24037","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24037","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24037","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087966123","display_name":"Caroline Hora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Caroline Hora","raw_affiliation_strings":["Department of Clinical Research, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028928677","display_name":"Pamela Romanque U","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CH","CL"],"is_corresponding":false,"raw_author_name":"Pamela Romanque","raw_affiliation_strings":["Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Santiago, Chile","Department of Clinical Research, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Clinical Research, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107024891","display_name":"Jean\u2010Fran\u00e7ois Dufour","orcid":"https://orcid.org/0000-0002-8062-1346","observed_orcids":["https://orcid.org/0000-0002-8062-1346"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jean-Fran\u00e7ois F. Dufour","raw_affiliation_strings":["Department of Clinical Research, University of Bern, Switzerland","University Clinic for Visceral Surgery and Medicine, Inselspital, Bern, Switzerland","fax: +41 31 632 97 65"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"University Clinic for Visceral Surgery and Medicine, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"fax: +41 31 632 97 65","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107024891"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":2.9763,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.90826261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"2","first_page":"577","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":1.0},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/raf-kinase-inhibition","display_name":"Raf kinase inhibition","score":0.7200000286102295},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7139999866485596},{"id":"https://openalex.org/keywords/scar-tissue","display_name":"scar tissue","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9548159837722778},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.7473801374435425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7210074663162231},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7134035229682922},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.5812617540359497},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.5738019943237305},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.5414109826087952},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.516927182674408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.513288676738739},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.48572713136672974},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.46193042397499084},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4576728343963623},{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.44574347138404846},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.44219115376472473},{"id":"https://openalex.org/C2910739307","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"Hepatocyte Growth Factor Receptor","level":5,"score":0.43358445167541504},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.42103123664855957},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.42063865065574646},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.39778807759284973},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28292155265808105},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20036935806274414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16300234198570251},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.15142062306404114},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.08219575881958008},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077214","descriptor_name":"Becaplermin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1002/hep.24037","doi":"https://doi.org/10.1002/hep.24037","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24037","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:21274878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21274878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.653.3321","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.653.3321","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.captura.uchile.cl/bitstream/handle/2250/14904/Hora_Caroline.pdf?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.862.7665","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.862.7665","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancer-du-foie.ch/wp-content/uploads/2015/07/Effect-of-Sorafenib-on-Murine-Liver-Regeneration.pdf","raw_type":"text"},{"id":"pmh:oai:boris.unibe.ch:7720","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/7720/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hora, Caroline; Romanque, Pamela; Dufour, Jean-Fran\u00e7ois (2011). Effect of sorafenib on murine liver regeneration. Hepatology, 53(2), pp. 577-86. Hoboken, N.J.: Wiley Interscience 10.1002/hep.24037 <http://dx.doi.org/10.1002/hep.24037>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/128887","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/128887","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Art\u00edculo de revista"},{"id":"pmh:oai:repositorio.uchile.cl:2250/128893","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/128893","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1002/hep.24037","doi":"https://doi.org/10.1002/hep.24037","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24037","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058747461.pdf","grobid_xml":"https://content.openalex.org/works/W2058747461.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1649526546","https://openalex.org/W1775749144","https://openalex.org/W1935188315","https://openalex.org/W1971837077","https://openalex.org/W1973514550","https://openalex.org/W1974487824","https://openalex.org/W1978116541","https://openalex.org/W1980969801","https://openalex.org/W1985712533","https://openalex.org/W1987306181","https://openalex.org/W1994193851","https://openalex.org/W1997533142","https://openalex.org/W2012792646","https://openalex.org/W2019660896","https://openalex.org/W2020458656","https://openalex.org/W2020678429","https://openalex.org/W2020830322","https://openalex.org/W2033973277","https://openalex.org/W2034699101","https://openalex.org/W2052467994","https://openalex.org/W2061863220","https://openalex.org/W2068562114","https://openalex.org/W2080992186","https://openalex.org/W2081926396","https://openalex.org/W2085547877","https://openalex.org/W2095839230","https://openalex.org/W2098577325","https://openalex.org/W2099259685","https://openalex.org/W2105831274","https://openalex.org/W2106787323","https://openalex.org/W2115754856","https://openalex.org/W2116436657","https://openalex.org/W2119076869","https://openalex.org/W2124657439","https://openalex.org/W2134967094","https://openalex.org/W2138610774","https://openalex.org/W2140765540","https://openalex.org/W2146421436","https://openalex.org/W2158965278","https://openalex.org/W2163775914","https://openalex.org/W2166271687","https://openalex.org/W2247149472","https://openalex.org/W2320220355","https://openalex.org/W2321119966","https://openalex.org/W2398895833","https://openalex.org/W2505091835","https://openalex.org/W3139763557","https://openalex.org/W4210995852","https://openalex.org/W6671048025","https://openalex.org/W6758325770"],"related_works":["https://openalex.org/W7098675564","https://openalex.org/W1997052786","https://openalex.org/W2480242113","https://openalex.org/W2365132297","https://openalex.org/W2147070263","https://openalex.org/W3030435411","https://openalex.org/W2365238242","https://openalex.org/W1975381656","https://openalex.org/W2130698077","https://openalex.org/W2135224460"],"abstract_inverted_index":{"UNLABELLED:":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"is":[4,20],"a":[5,64,129],"common":[6],"cause":[7],"of":[8,14,26,37,39,75,131,166,237,256],"cancer-related":[9],"death.":[10],"Sorafenib":[11,62],"prolongs":[12],"survival":[13],"patients":[15],"with":[16],"advanced":[17],"disease":[18],"and":[19,32,51,58,119,138,152,186,216,275],"approved":[21],"for":[22,67,98],"the":[23,40,59,102,108],"systemic":[24],"treatment":[25,185,187],"unresectable":[27],"HCC.":[28],"It":[29],"possesses":[30],"antiangiogenic":[31],"antiproliferative":[33],"properties":[34],"by":[35,145],"way":[36],"inhibition":[38],"receptor":[41,48],"tyrosine":[42],"kinases":[43],"vascular":[44],"endothelial":[45],"growth":[46,53,154],"factor":[47,54,155],"2":[49],"(VEGFR-2)":[50],"platelet-derived":[52],"receptor-beta":[55],"1/2":[56],"(PDGFR-\u03b2)":[57],"kinase":[60,141],"RAF.":[61],"represents":[63],"candidate":[65],"compound":[66],"adjuvant":[68],"therapy":[69],"in":[70,160,240,251,261,269],"HCC":[71],"patients.":[72],"The":[73],"aim":[74],"our":[76],"study":[77,283],"was":[78,126,169,259],"to":[79,204],"investigate":[80],"whether":[81],"sorafenib":[82,89,184,244,272,286],"affects":[83],"liver":[84,133,148,161,181,198,291,303],"regeneration.":[85,182,304],"C57BL6":[86],"mice":[87,262],"received":[88],"orally":[90],"at":[91,200,225],"30":[92],"mg/kg/day":[93],"or":[94,106,112],"its":[95],"vehicle":[96],"either":[97],"14":[99],"days":[100],"until":[101],"day":[103,109,174,190],"before":[104,175,295],"hepatectomy":[105,300],"starting":[107],"after":[110,122,191,245,273,299],"surgery":[111,176,192,274],"both.":[113],"Animals":[114],"were":[115,143,158,249,267],"sacrificed":[116],"24,":[117],"72,":[118],"120":[120,201,226],"hours":[121,202],"hepatectomy.":[123],"Liver":[124],"regeneration":[125,199,292],"calculated":[127],"as":[128],"percent":[130],"initial":[132],"weight.":[134],"Bromodeoxyuridine":[135],"(BrdU)":[136],"incorporation":[137,233],"phospho-extracellular":[139],"signal-regulated":[140],"(pERK1/2)":[142],"determined":[144],"immunohistochemistry":[146],"on":[147,180,197,277,290],"sections.":[149,279],"VEGF-A,":[150],"PDGF-BB,":[151],"hepatocyte":[153],"(HGF)":[156],"levels":[157,248,258],"measured":[159],"tissue":[162,168],"homogenates.":[163],"Histological":[164],"analysis":[165],"scar":[167],"performed.":[170],"Treatment":[171],"stopped":[172],"1":[173,189],"had":[177,193],"no":[178],"impact":[179,289],"Continuous":[183],"started":[188],"statistically":[194],"significant":[195],"effects":[196],"compared":[203],"vehicle-treated":[205],"control":[206,212,221],"animals":[207,270],"(72%":[208],"\u00b1":[209,214,218,223],"12":[210],"versus":[211,220],"88%":[213],"15":[215],"70%":[217],"13":[219],"86%":[222],"5":[224],"hours,":[227],"both":[228,241],"P":[229],"\u2264":[230],"0.02).":[231],"BrdU":[232],"showed":[234],"decreased":[235],"numbers":[236],"positive":[238],"nuclei":[239],"groups":[242],"receiving":[243,263,271],"surgery.":[246],"Phospho-ERK":[247],"reduced":[250],"sorafenib-treated":[252],"animals.":[253],"An":[254],"increase":[255],"VEGF-A":[257],"observed":[260,268],"sorafenib.":[264],"Wound-healing":[265],"complications":[266],"confirmed":[276],"histological":[278],"CONCLUSION:":[280],"This":[281],"preclinical":[282],"shows":[284],"that":[285],"did":[287],"not":[288],"when":[293],"ceased":[294],"surgery;":[296],"however,":[297],"administration":[298],"affected":[301],"late":[302]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}