{"id":"https://openalex.org/W2058735130","doi":"https://doi.org/10.1074/jbc.m112.355578","title":"Molecular Recognition of Candida albicans (1\u21922)-\u03b2-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues","display_name":"Molecular Recognition of Candida albicans (1\u21922)-\u03b2-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues","publication_year":2012,"publication_date":"2012-04-06","ids":{"openalex":"https://openalex.org/W2058735130","doi":"https://doi.org/10.1074/jbc.m112.355578","mag":"2058735130","pmid":"https://pubmed.ncbi.nlm.nih.gov/22493450","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3365708"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.355578","doi":"https://doi.org/10.1074/jbc.m112.355578","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.355578","pdf_url":"http://www.jbc.org/article/S0021925820500537/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820500537/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Margaret A. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Margaret A. Johnson","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada. maggie.johnson@ualberta.ca","Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada ()"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada. maggie.johnson@ualberta.ca","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada ()","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103436938","display_name":"Jonathan Cartmell","orcid":"https://orcid.org/0000-0003-4663-831X","observed_orcids":["https://orcid.org/0000-0003-4663-831X"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan Cartmell","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017732395","display_name":"Nina E. Weisser","orcid":"https://orcid.org/0000-0002-9903-2429","observed_orcids":["https://orcid.org/0000-0002-9903-2429"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Nina E. Weisser","raw_affiliation_strings":["School of Chemistry, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086719622","display_name":"Robert J. Woods","orcid":"https://orcid.org/0000-0002-2400-6293","observed_orcids":["https://orcid.org/0000-0002-2400-6293"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Robert J. Woods","raw_affiliation_strings":["Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602","School of Chemistry, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"School of Chemistry, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073005007","display_name":"David R. Bundle","orcid":"https://orcid.org/0000-0003-0497-3961","observed_orcids":["https://orcid.org/0000-0003-0497-3961"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David R. Bundle","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3236,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.87555745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"287","issue":"22","first_page":"18078","last_page":"18090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunodominant-epitopes","display_name":"immunodominant epitopes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/oligosaccharide-chain-length","display_name":"oligosaccharide chain length","score":0.6869999766349792},{"id":"https://openalex.org/keywords/glycoconjugate-vaccines","display_name":"glycoconjugate vaccines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antifungal-protection","display_name":"antifungal protection","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2778312041","wikidata":"https://www.wikidata.org/wiki/Q421360","display_name":"Trisaccharide","level":2,"score":0.7776780128479004},{"id":"https://openalex.org/C13426554","wikidata":"https://www.wikidata.org/wiki/Q416019","display_name":"Glycoconjugate","level":2,"score":0.7693920731544495},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7484233975410461},{"id":"https://openalex.org/C2779719659","wikidata":"https://www.wikidata.org/wiki/Q24577942","display_name":"Mannan","level":3,"score":0.6665065288543701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6578065752983093},{"id":"https://openalex.org/C2778297098","wikidata":"https://www.wikidata.org/wiki/Q419827","display_name":"Tetrasaccharide","level":3,"score":0.6325188875198364},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.5433387160301208},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.5431957840919495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5282242298126221},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5042401552200317},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4634110629558563},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.4441649615764618},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.4230876564979553},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3942244052886963},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31938523054122925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22872599959373474},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.17487025260925293},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15043485164642334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07444882392883301}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008351","descriptor_name":"Mannans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008351","descriptor_name":"Mannans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008351","descriptor_name":"Mannans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1074/jbc.m112.355578","doi":"https://doi.org/10.1074/jbc.m112.355578","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.355578","pdf_url":"http://www.jbc.org/article/S0021925820500537/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2658111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3365708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22493450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22493450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3365708","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3365708/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:https://researchrepository.universityofgalway.ie:10379/12099","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/12099","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:http://www.rian.ie/159155/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10379/12099","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:aran.library.nuigalway.ie/:10379/12099","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/12099","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchrepository.universityofgalway.ie:10379/12099","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/12099","pdf_url":null,"source":{"id":"https://openalex.org/S7407055151","display_name":"University of Galway Research Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"doi:10.13025/25852","doi":"https://doi.org/10.13025/25852","is_oa":true,"landing_page_url":"https://doi.org/10.13025/25852","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.355578","doi":"https://doi.org/10.1074/jbc.m112.355578","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.355578","pdf_url":"http://www.jbc.org/article/S0021925820500537/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4039635922","display_name":"Integrating Experiment and Theory to Characterize Diagnostic Antibody Specificity","funder_award_id":"R01GM094919","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5253638501","display_name":"Resource for Integrated Glycotechnology","funder_award_id":"P41GM103390","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G596277974","display_name":null,"funder_award_id":"RR 005351","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6760459980","display_name":"Resource for Integrated Glycotechnology","funder_award_id":"P41RR005351","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058735130.pdf","grobid_xml":"https://content.openalex.org/works/W2058735130.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W64140222","https://openalex.org/W633547788","https://openalex.org/W937515754","https://openalex.org/W1523765851","https://openalex.org/W1536698017","https://openalex.org/W1884435079","https://openalex.org/W1966613156","https://openalex.org/W1970467918","https://openalex.org/W1980829326","https://openalex.org/W1986191025","https://openalex.org/W1989228404","https://openalex.org/W1991691232","https://openalex.org/W1999992455","https://openalex.org/W2000075765","https://openalex.org/W2009654960","https://openalex.org/W2013043292","https://openalex.org/W2013638037","https://openalex.org/W2014860988","https://openalex.org/W2017975787","https://openalex.org/W2022268596","https://openalex.org/W2022652050","https://openalex.org/W2025880126","https://openalex.org/W2028743831","https://openalex.org/W2029377282","https://openalex.org/W2038622833","https://openalex.org/W2043000981","https://openalex.org/W2047334547","https://openalex.org/W2051405598","https://openalex.org/W2060289095","https://openalex.org/W2064817138","https://openalex.org/W2066807229","https://openalex.org/W2069123478","https://openalex.org/W2071287957","https://openalex.org/W2071486470","https://openalex.org/W2076755375","https://openalex.org/W2084069365","https://openalex.org/W2085387269","https://openalex.org/W2098943363","https://openalex.org/W2100816704","https://openalex.org/W2118420662","https://openalex.org/W2134967712","https://openalex.org/W2135037409","https://openalex.org/W2137575148","https://openalex.org/W2139574393","https://openalex.org/W2156792116","https://openalex.org/W2158200334","https://openalex.org/W2166021114","https://openalex.org/W2487856913","https://openalex.org/W4248714559","https://openalex.org/W4249923656"],"related_works":["https://openalex.org/W1966613156","https://openalex.org/W2312357577","https://openalex.org/W3165028084","https://openalex.org/W2013043292","https://openalex.org/W2275073002","https://openalex.org/W2487856913","https://openalex.org/W24797660","https://openalex.org/W2043000981","https://openalex.org/W2072237621","https://openalex.org/W1885188225"],"abstract_inverted_index":{"A":[0],"self-consistent":[1],"model":[2],"of":[3,68,88,95,109,135,163,175,180],"\u03b2-mannan":[4],"oligosaccharides":[5],"bound":[6],"to":[7,61,113,133,160,172],"a":[8,96,99,153,176,181],"monoclonal":[9],"antibody,":[10],"C3.1,":[11,137],"that":[12,43,119,134],"protects":[13],"mice":[14],"against":[15],"Candida":[16],"albicans":[17],"has":[18],"been":[19],"developed":[20],"through":[21],"chemical":[22,127],"mapping,":[23],"NMR":[24],"spectroscopic,":[25],"and":[26,34,54,71,171],"computational":[27],"studies.":[28],"This":[29],"antibody":[30],"optimally":[31],"binds":[32],"di-":[33,70],"trisaccharide":[35,72,154],"epitopes,":[36],"whereas":[37],"larger":[38],"oligomers":[39],"bind":[40,56],"with":[41,46,84,152],"affinities":[42],"markedly":[44],"decrease":[45],"increasing":[47],"chain":[48],"length.":[49],"The":[50,156],"(1\u21922)-\u03b2-linked":[51],"di-,":[52],"tri-,":[53],"tetramannosides":[55],"in":[57,101,146,169],"helical":[58],"conformations":[59],"similar":[60,132],"the":[62,69,77,81,85,102,110,114,161,173],"solution":[63],"global":[64],"minimum.":[65],"Antibody":[66],"recognition":[67,130],"is":[73],"primarily":[74],"dependent":[75],"on":[76],"mannose":[78],"unit":[79],"at":[80],"reducing":[82,115],"end,":[83],"hydrophobic":[86],"face":[87],"this":[89],"sugar":[90,111],"being":[91],"tightly":[92],"bound.":[93],"Recognition":[94],"tetrasaccharide":[97],"involves":[98],"frameshift":[100],"ligand":[103],"interaction,":[104],"shown":[105],"by":[106,126,139],"strong":[107],"binding":[108],"adjacent":[112],"end.":[116],"We":[117],"show":[118],"frameshifting":[120],"may":[121],"also":[122,144],"be":[123],"deliberately":[124],"induced":[125],"modifications.":[128],"Molecular":[129],"patterns":[131],"mAb":[136],"determined":[138],"saturation":[140],"transfer":[141],"difference-NMR,":[142],"were":[143],"observed":[145],"polyclonal":[147],"sera":[148],"from":[149],"rabbits":[150],"immunized":[151],"glycoconjugate.":[155],"latter":[157],"observation":[158],"points":[159],"importance":[162],"internal":[164],"residues":[165],"as":[166],"immunodominant":[167],"epitopes":[168],"(1\u21922)-\u03b2-mannans":[170],"viability":[174],"glycoconjugate":[177],"vaccine":[178],"composed":[179],"minimal":[182],"length":[183],"oligosaccharide":[184],"hapten.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
