{"id":"https://openalex.org/W2058727495","doi":"https://doi.org/10.1002/hep.26655","title":"Prognostic Impact of Telomere Maintenance Gene Polymorphisms on Hepatocellular Carcinoma Patients With Chronic Hepatitis B","display_name":"Prognostic Impact of Telomere Maintenance Gene Polymorphisms on Hepatocellular Carcinoma Patients With Chronic Hepatitis B","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2058727495","doi":"https://doi.org/10.1002/hep.26655","mag":"2058727495","pmid":"https://pubmed.ncbi.nlm.nih.gov/23907815"},"language":"en","primary_location":{"id":"doi:10.1002/hep.26655","doi":"https://doi.org/10.1002/hep.26655","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.26655","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Seok Won Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok Won Jung","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039396082","display_name":"Neung Hwa Park","orcid":"https://orcid.org/0000-0002-5648-9189","observed_orcids":["https://orcid.org/0000-0002-5648-9189"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Neung Hwa Park","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","These authors contributed equally to this work as correspondence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]},{"raw_affiliation_string":"These authors contributed equally to this work as correspondence","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001822288","display_name":"Jung Woo Shin","orcid":"https://orcid.org/0000-0001-7001-0341","observed_orcids":["https://orcid.org/0000-0001-7001-0341"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Woo Shin","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110016705","display_name":"Bo Ryung Park","orcid":"https://orcid.org/0009-0004-7751-8585","observed_orcids":["https://orcid.org/0009-0004-7751-8585"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bo Ryung Park","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028997141","display_name":"Chang Jae Kim","orcid":"https://orcid.org/0000-0003-4202-2171","observed_orcids":["https://orcid.org/0000-0003-4202-2171"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Jae Kim","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780253","display_name":"Jong-Eun Lee","orcid":"https://orcid.org/0000-0001-8115-3743","observed_orcids":["https://orcid.org/0000-0001-8115-3743"]},"institutions":[{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Eun Lee","raw_affiliation_strings":["DNA Link, Incorporated, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA Link, Incorporated, Seoul, Korea","institution_ids":["https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065265685","display_name":"Eun\u2010Soon Shin","orcid":"https://orcid.org/0000-0001-8408-2696","observed_orcids":["https://orcid.org/0000-0001-8408-2696"]},"institutions":[{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Soon Shin","raw_affiliation_strings":["DNA Link, Incorporated, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA Link, Incorporated, Seoul, Korea","institution_ids":["https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644155","display_name":"Jeong\u2010Ah Kim","orcid":"https://orcid.org/0000-0002-7662-6857","observed_orcids":["https://orcid.org/0000-0002-7662-6857"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong A Kim","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea","University of Ulsan College of Medicine Department of Internal Medicine Seoul Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"University of Ulsan College of Medicine Department of Internal Medicine Seoul Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021313650","display_name":"Young\u2013Hwa Chung","orcid":"https://orcid.org/0000-0002-3408-9336","observed_orcids":["https://orcid.org/0000-0002-3408-9336"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Hwa Chung","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea","These authors contributed equally to this work as correspondence","University of Ulsan College of Medicine Department of Internal Medicine Seoul Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"These authors contributed equally to this work as correspondence","institution_ids":[]},{"raw_affiliation_string":"University of Ulsan College of Medicine Department of Internal Medicine Seoul Korea","institution_ids":["https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021313650","https://openalex.org/A5039396082"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I4210136447"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.751,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.82327536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"5","first_page":"1912","last_page":"1920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.09300000220537186,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.968999981880188},{"id":"https://openalex.org/keywords/telomere-maintenance-genes","display_name":"telomere maintenance genes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7940000295639038},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hbv-related-liver-cancer","display_name":"HBV-related liver cancer","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8958802223205566},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8337665796279907},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5843874216079712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.567341148853302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5569004416465759},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5154667496681213},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.454702228307724},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4311818480491638},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39599359035491943},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3668329417705536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32219183444976807},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2756105959415436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24293893575668335},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.08694303035736084}],"mesh":[{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.26655","doi":"https://doi.org/10.1002/hep.26655","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.26655","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:23907815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23907815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1974907504","https://openalex.org/W1977301309","https://openalex.org/W1983856113","https://openalex.org/W1984941194","https://openalex.org/W1985910710","https://openalex.org/W1990849983","https://openalex.org/W2001566280","https://openalex.org/W2019063243","https://openalex.org/W2035720189","https://openalex.org/W2037803457","https://openalex.org/W2045338804","https://openalex.org/W2048662077","https://openalex.org/W2055585661","https://openalex.org/W2057378223","https://openalex.org/W2060423420","https://openalex.org/W2062395030","https://openalex.org/W2068428255","https://openalex.org/W2079378073","https://openalex.org/W2085760291","https://openalex.org/W2085829147","https://openalex.org/W2086055165","https://openalex.org/W2092476887","https://openalex.org/W2099395083","https://openalex.org/W2102945991","https://openalex.org/W2113307719","https://openalex.org/W2114839347","https://openalex.org/W2116683428","https://openalex.org/W2117981680","https://openalex.org/W2143239393","https://openalex.org/W2144289593","https://openalex.org/W2145950913","https://openalex.org/W2147017705","https://openalex.org/W2150490516","https://openalex.org/W2154841493","https://openalex.org/W2155635136","https://openalex.org/W2160621707","https://openalex.org/W2162299386","https://openalex.org/W2162530578","https://openalex.org/W2163486683","https://openalex.org/W2169002350","https://openalex.org/W4210973123"],"related_works":["https://openalex.org/W2786271517","https://openalex.org/W3004755191","https://openalex.org/W2011749329","https://openalex.org/W2406330191","https://openalex.org/W3035750210","https://openalex.org/W2013301628","https://openalex.org/W2947728824","https://openalex.org/W1974907504","https://openalex.org/W2318978284","https://openalex.org/W4400144630"],"abstract_inverted_index":{"UNLABELLED:":[0],"Our":[1],"goal":[2],"was":[3,98,164,172,196,231],"to":[4],"determine":[5],"whether":[6],"single-nucleotide":[7],"polymorphisms":[8],"(SNPs)":[9],"of":[10,20,34,63,74,80,95,134,180,184,252,263,268],"telomere":[11,36,253],"maintenance":[12,37,254],"genes":[13,38,255],"influence":[14],"the":[15,72,78,101,110,128,156,167,178,185,234,250,261,266],"development":[16,79,97,262],"and":[17,44,67,82,112,143,159,189,229,265],"clinical":[18],"outcomes":[19],"patients":[21,41,66,200,270],"with":[22,42,77,201,203,212,271],"hepatitis":[23,46],"B":[24,47],"virus":[25,48],"(HBV)-associated":[26],"hepatocellular":[27],"carcinoma":[28],"(HCC).":[29],"We":[30,70],"evaluated":[31],"20":[32],"SNPs":[33,55,150,188,251],"five":[35,186],"in":[39,59,108,166,233,260],"702":[40],"HCC":[43,65,81,96,202,264,269],"351":[45],"surface":[49],"antigen-positive":[50],"controls":[51],"without":[52],"HCC.":[53],"Significant":[54],"were":[56],"then":[57],"validated":[58,165],"an":[60],"independent":[61],"cohort":[62,236],"857":[64],"429":[68],"controls.":[69],"assessed":[71],"association":[73,176],"each":[75],"SNP":[76,107],"overall":[83,157,190],"survival":[84,162,194,267],"through":[85],"a":[86,152,160,173,257],"multivariate":[87],"Cox":[88],"proportional":[89],"analysis.":[90],"A":[91],"significantly":[92,197],"increased":[93],"risk":[94],"identified":[99],"for":[100,199],"telomerase-associated":[102],"protein":[103],"1":[104,136,148],"(TEP1)":[105],"rs1713449":[106],"both":[109],"discovery":[111],"replication":[113,168,235],"phases":[114],"(combined":[115],"odds":[116],"ratio":[117],"=":[118,121,224,243],"1.42,":[119],"P":[120,223,242],"9.378":[122],"\u00d7":[123,226],"10(-5)":[124,227],").":[125],"In":[126],"addition,":[127],"TEP1":[129,131],"rs1713449,":[130],"rs872072,":[132],"protection":[133],"telomeres":[135],"homolog":[137],"rs7784168,":[138],"telomerase":[139],"reverse":[140],"transcriptase":[141],"rs13167280,":[142],"telomeric":[144],"repeat":[145],"binding":[146],"factor":[147],"rs2306494":[149],"had":[151],"significant":[153,174],"effect":[154,163],"on":[155],"survival,":[158],"similar":[161],"cohort.":[169],"Moreover,":[170],"there":[171],"dose-dependent":[175],"between":[177],"number":[179],"putatively":[181,207],"high-risk":[182,208,216],"genotypes":[183,209,217],"aforementioned":[187],"survival.":[191],"The":[192],"median":[193],"time":[195],"prolonged":[198],"two":[204],"or":[205,214],"fewer":[206],"versus":[210,219,238],"those":[211],"three":[213],"more":[215],"(85":[218],"44":[220],"months,":[221,240],"log-rank":[222,241],"4.483":[225],"),":[228],"this":[230],"demonstrated":[232],"(52":[237],"37":[239],"0.026).":[244],"CONCLUSION:":[245],"These":[246],"observations":[247],"suggest":[248],"that":[249],"play":[256],"potential":[258],"role":[259],"chronic":[272],"HBV":[273],"infections.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}