{"id":"https://openalex.org/W2058725644","doi":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","title":"THE EFFECT OF SOME \u03b12\u2010ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON GASTROINTESTINAL TRANSIT IN MICE: INFLUENCE OF MORPHINE, CASTOR OIL AND GLUCOSE","display_name":"THE EFFECT OF SOME \u03b12\u2010ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON GASTROINTESTINAL TRANSIT IN MICE: INFLUENCE OF MORPHINE, CASTOR OIL AND GLUCOSE","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2058725644","doi":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","mag":"2058725644","pmid":"https://pubmed.ncbi.nlm.nih.gov/8094327"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1681.1993.tb01495.x","doi":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066524696","display_name":"Badreldin H. Ali","orcid":"https://orcid.org/0000-0001-6491-6278","observed_orcids":["https://orcid.org/0000-0001-6491-6278"]},"institutions":[{"id":"https://openalex.org/I149840157","display_name":"Al-Arab Medical University","ror":"https://ror.org/03ke9vf24","country_code":"LY","type":"education","lineage":["https://openalex.org/I149840157"]}],"countries":["LY"],"is_corresponding":true,"raw_author_name":"B. H. Ali","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya","institution_ids":["https://openalex.org/I149840157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017941060","display_name":"A.A. Bashir","orcid":"https://orcid.org/0000-0002-6559-9283","observed_orcids":["https://orcid.org/0000-0002-6559-9283"]},"institutions":[{"id":"https://openalex.org/I149840157","display_name":"Al-Arab Medical University","ror":"https://ror.org/03ke9vf24","country_code":"LY","type":"education","lineage":["https://openalex.org/I149840157"]}],"countries":["LY"],"is_corresponding":false,"raw_author_name":"A. A. Bashir","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya","institution_ids":["https://openalex.org/I149840157"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066524696"],"corresponding_institution_ids":["https://openalex.org/I149840157"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4784,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.64015724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"1","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8730000257492065},{"id":"https://openalex.org/keywords/alpha2-adrenoceptor-antagonists","display_name":"alpha2-adrenoceptor antagonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-transit","display_name":"gastrointestinal transit","score":0.9950000047683716},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tizanidine","display_name":"tizanidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/b-ht-920","display_name":"B-HT 920","score":0.9900000095367432},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idazoxan","display_name":"idazoxan","score":1.0},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/castor-oil","display_name":"castor oil","score":0.8130000233650208},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.9599999785423279},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8930000066757202},{"id":"https://openalex.org/keywords/charcoal-meal-test","display_name":"charcoal meal test","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2777676773","wikidata":"https://www.wikidata.org/wiki/Q412226","display_name":"Yohimbine","level":4,"score":0.918044924736023},{"id":"https://openalex.org/C2780939551","wikidata":"https://www.wikidata.org/wiki/Q5987770","display_name":"Idazoxan","level":5,"score":0.9029074907302856},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.7926058769226074},{"id":"https://openalex.org/C2911073721","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal transit","level":2,"score":0.6977800726890564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6056830883026123},{"id":"https://openalex.org/C2779761043","wikidata":"https://www.wikidata.org/wiki/Q423538","display_name":"Tizanidine","level":3,"score":0.5848701000213623},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49432921409606934},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46449047327041626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44963639974594116},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4141901433467865},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2908179759979248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27509838342666626},{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.2715272307395935},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1255285143852234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0828421413898468},{"id":"https://openalex.org/C2779012798","wikidata":"https://www.wikidata.org/wiki/Q117060","display_name":"Spasticity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002368","descriptor_name":"Castor Oil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1681.1993.tb01495.x","doi":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1681.1993.tb01495.x","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:8094327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8094327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental pharmacology & physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W144690374","https://openalex.org/W1980499900","https://openalex.org/W1989632862","https://openalex.org/W2002674925","https://openalex.org/W2003290596","https://openalex.org/W2022629335","https://openalex.org/W2040810388","https://openalex.org/W2058879711","https://openalex.org/W2060515060","https://openalex.org/W2070308702","https://openalex.org/W2070477631","https://openalex.org/W2075197880","https://openalex.org/W2086166704","https://openalex.org/W2089378788","https://openalex.org/W2125535640","https://openalex.org/W2138468089","https://openalex.org/W2140755810","https://openalex.org/W2142367997","https://openalex.org/W2143051404","https://openalex.org/W2265693567","https://openalex.org/W2308052730","https://openalex.org/W2421041331","https://openalex.org/W2473938287","https://openalex.org/W4407023762"],"related_works":["https://openalex.org/W2416561521","https://openalex.org/W7071184433","https://openalex.org/W2094261855","https://openalex.org/W2151755964","https://openalex.org/W2076772936","https://openalex.org/W2333098316","https://openalex.org/W2129608232","https://openalex.org/W1861656701","https://openalex.org/W2125535640","https://openalex.org/W2039819600"],"abstract_inverted_index":{"1.":[0],"The":[1,36,111],"effects":[2],"of":[3,6,102,114,122,184],"graded":[4],"doses":[5],"the":[7,16,31,47,50,55,100,120,142,182],"alpha":[8,17],"2-adrenoceptor":[9,18],"agonists":[10,37],"clonidine,":[11],"tizanidine":[12,65,174],"and":[13,15,21,40,46,68,87,106,130,177,189],"BHT-920,":[14],"antagonists":[19,48],"yohimbine":[20,73,103,149],"idazoxan,":[22],"on":[23,141],"gastrointestinal":[24,44,56,92,123,145],"transit":[25,124,146],"were":[26],"investigated":[27],"in":[28,43,144,164],"mice":[29],"using":[30],"charcoal":[32],"meal":[33],"test.":[34],"2.":[35],"produced":[38,49,125],"significant":[39,139],"dose-dependent":[41],"decreases":[42],"transit,":[45,57],"opposite":[51],"effect.":[52],"In":[53],"affecting":[54],"clonidine":[58,127],"(1":[59,81,108,128,154,172],"mg/kg)":[60,67,75,89,105,129,151,176,180],"was":[61,76,96],"as":[62,64,77,79],"effective":[63,78],"(12":[66,175],"BHT-920":[69,131,178],"(40":[70,132,179],"mg/kg),":[71,173],"while":[72],"(2":[74,104,150],"idazoxan":[80,107,153],"mg/kg).":[82,109,133,155],"3.":[83],"Morphine":[84],"(2,":[85],"4":[86],"8":[88],"significantly":[90,97],"inhibited":[91],"transit.":[93],"This":[94],"effect":[95,140],"reversed":[98],"by":[99,126,148],"co-administration":[101],"4.":[110],"acute":[112],"administration":[113],"glucose":[115],"(5.04":[116],"g/kg,":[117],"i.p.)":[118],"potentiated":[119],"inhibition":[121],"Glucose":[134],"treatment,":[135],"however,":[136],"had":[137],"no":[138],"increase":[143],"induced":[147,162],"or":[152],"5.":[156],"Castor":[157],"oil":[158],"(0.25":[159],"mL/mouse,":[160],"orally)":[161],"diarrhoea":[163,185],"saline-treated":[165],"animals":[166],"within":[167],"about":[168],"45":[169],"min.":[170],"Clonidine":[171],"delayed":[181],"occurrence":[183],"to":[186],"2.1,":[187],"1.2":[188],"1.4":[190],"h,":[191],"respectively.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}