{"id":"https://openalex.org/W2058720902","doi":"https://doi.org/10.1021/op030037e","title":"An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol","display_name":"An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol","publication_year":2003,"publication_date":"2003-12-10","ids":{"openalex":"https://openalex.org/W2058720902","doi":"https://doi.org/10.1021/op030037e","mag":"2058720902"},"language":"en","primary_location":{"id":"doi:10.1021/op030037e","doi":"https://doi.org/10.1021/op030037e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/op030037e","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085781108","display_name":"Thomas Peter Sabroe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Thomas Peter Sabroe","raw_affiliation_strings":["Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078583690","display_name":"Henrik Pedersen","orcid":"https://orcid.org/0000-0003-4911-5119","observed_orcids":["https://orcid.org/0000-0003-4911-5119"]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Pedersen","raw_affiliation_strings":["Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014398538","display_name":"Ernst Binderup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165112","display_name":"Leo Pharma (Denmark)","ror":"https://ror.org/05tzrdd39","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ernst Binderup","raw_affiliation_strings":["Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Process Development and Medicinal Chemistry, LEO Pharma, DK-2750 Ballerup, Denmark","institution_ids":["https://openalex.org/I4210165112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085781108"],"corresponding_institution_ids":["https://openalex.org/I4210165112"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.15076811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"133","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-analogs","display_name":"vitamin D analogs","score":0.8809999823570251},{"id":"https://openalex.org/keywords/key-intermediate-synthesis","display_name":"key intermediate synthesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/vitamin-d2","display_name":"vitamin D2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/organolithium-reagents","display_name":"organolithium reagents","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cerium-iii-chloride","display_name":"cerium(III) chloride","score":0.8040000200271606},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.4230000078678131},{"id":"https://openalex.org/keywords/drug-synthesis","display_name":"drug synthesis","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.7669599056243896},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5955750346183777},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5775192975997925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5683858394622803},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5450875759124756},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.45548078417778015},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18839949369430542},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16929173469543457},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11159646511077881},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06288465857505798},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/op030037e","doi":"https://doi.org/10.1021/op030037e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/op030037e","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research & Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1976278863","https://openalex.org/W2046143876","https://openalex.org/W2053683569","https://openalex.org/W2069626566","https://openalex.org/W2520916097"],"related_works":["https://openalex.org/W2055116843","https://openalex.org/W2172053709","https://openalex.org/W2950816295","https://openalex.org/W4399067625","https://openalex.org/W2010466361","https://openalex.org/W4254197220","https://openalex.org/W941090345","https://openalex.org/W2337885742","https://openalex.org/W1965261951","https://openalex.org/W2006109141"],"abstract_inverted_index":{"In":[0],"the":[1,6,9,13,29],"key":[2,10,41],"synthetic":[3],"step":[4],"in":[5,37,49],"manufacture":[7],"of":[8],"intermediate":[11,42],"for":[12],"biologically":[14],"active":[15],"vitamin":[16,46],"D":[17,47],"analogue,":[18],"seocalcitol,":[19],"a":[20],"more":[21],"practical":[22],"and":[23,33],"attractive":[24],"procedure":[25],"is":[26,43],"achieved":[27],"using":[28],"commercially":[30],"available":[31],"EtMgBr":[32],"CeCl":[34],"3,":[35],"resulting":[36],"79%":[38],"yield.":[39,59],"The":[40],"synthesised":[44],"from":[45],"2":[48],"10":[50],"steps":[51],"with":[52],"only":[53],"three":[54],"isolations,":[55],"giving":[56],"21%":[57],"overall":[58]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}