{"id":"https://openalex.org/W2058718704","doi":"https://doi.org/10.2106/00004623-200506000-00012","title":"ARTICULAR CARTILAGE DEGENERATION IN POST-COLLAPSE OSTEONECROSIS OF THE FEMORAL HEAD","display_name":"ARTICULAR CARTILAGE DEGENERATION IN POST-COLLAPSE OSTEONECROSIS OF THE FEMORAL HEAD","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2058718704","doi":"https://doi.org/10.2106/00004623-200506000-00012","mag":"2058718704","pmid":"https://pubmed.ncbi.nlm.nih.gov/15930536"},"language":"en","primary_location":{"id":"doi:10.2106/00004623-200506000-00012","doi":"https://doi.org/10.2106/00004623-200506000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.2106/00004623-200506000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S128848949","display_name":"Journal of Bone and Joint Surgery","issn_l":"0021-9355","issn":["0021-9355","1058-2436","1535-1386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Bone and Joint Surgery-American Volume","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090368197","display_name":"Robert A. Magnussen","orcid":"https://orcid.org/0000-0001-9864-1508","observed_orcids":["https://orcid.org/0000-0001-9864-1508"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"ROBERT A. MAGNUSSEN","raw_affiliation_strings":["Department of Orthopaedics, Vanderbilt University, 137 Medical Center South, Nashville, TN 37232","Department of Orthopaedics, Vanderbilt University, 137 Medical Center South, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Vanderbilt University, 137 Medical Center South, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Orthopaedics, Vanderbilt University, 137 Medical Center South, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"FARSHID GUILAK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FARSHID GUILAK","raw_affiliation_strings":["Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Box 3093, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Box 3093, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":null,"display_name":"THOMAS P. VAIL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THOMAS P. VAIL","raw_affiliation_strings":["Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Box 3332, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Box 3332, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090368197"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":2.1484,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.86055583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"6","first_page":"1272","last_page":"1272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avascular-necrosis-of-the-femoral-head","display_name":"osteonecrosis of the femoral head","score":0.9959999918937683},{"id":"https://openalex.org/keywords/articular-cartilage-degeneration","display_name":"articular cartilage degeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/radiological-staging","display_name":"radiological staging","score":0.843999981880188},{"id":"https://openalex.org/keywords/cartilage-biomechanics","display_name":"cartilage biomechanics","score":0.906000018119812},{"id":"https://openalex.org/keywords/cartilage-histology","display_name":"cartilage histology","score":0.9589999914169312},{"id":"https://openalex.org/keywords/femoral-head-collapse","display_name":"femoral head collapse","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2779100257","wikidata":"https://www.wikidata.org/wiki/Q582849","display_name":"Femoral head","level":2,"score":0.8768466114997864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8402777910232544},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7426674962043762},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.6463745832443237},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.5813209414482117},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5055975914001465},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.47889652848243713},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.4517887234687805},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.44858598709106445},{"id":"https://openalex.org/C2909674901","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Cartilage damage","level":5,"score":0.44097796082496643},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.43581804633140564},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.403658002614975},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.328019917011261},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3235906958580017},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29220718145370483},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23491638898849487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019637","descriptor_name":"Orthopedic Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2106/00004623-200506000-00012","doi":"https://doi.org/10.2106/00004623-200506000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.2106/00004623-200506000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S128848949","display_name":"Journal of Bone and Joint Surgery","issn_l":"0021-9355","issn":["0021-9355","1058-2436","1535-1386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Bone and Joint Surgery-American Volume","raw_type":"journal-article"},{"id":"doi:10.2106/jbjs.d.01936","doi":"https://doi.org/10.2106/jbjs.d.01936","is_oa":false,"landing_page_url":"https://doi.org/10.2106/jbjs.d.01936","pdf_url":null,"source":{"id":"https://openalex.org/S128848949","display_name":"Journal of Bone and Joint Surgery","issn_l":"0021-9355","issn":["0021-9355","1058-2436","1535-1386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Bone and Joint Surgery (American)","raw_type":"journal-article"},{"id":"pmid:15930536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15930536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of bone and joint surgery. American volume","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2189290587","display_name":null,"funder_award_id":"AR 50245","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2255368047","display_name":"ENHANCED RESEARCH TRAINING PROGRAM FOR MEDICAL STUDENTS","funder_award_id":"T35GM008679","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2836112867","display_name":null,"funder_award_id":"AR48182","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3340408562","display_name":"Biomechanics and Inflammation in Osteoarthritis","funder_award_id":"P01AR050245","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3851968304","display_name":null,"funder_award_id":"AG 15768","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6454837097","display_name":"Viscoelastic Properties of Normal and OA Chondrons","funder_award_id":"R01AG015768","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7633619524","display_name":"Mechanical and Osmotic Signaling in Chondrocytes","funder_award_id":"R01AR048182","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W12671366","https://openalex.org/W206711978","https://openalex.org/W300208199","https://openalex.org/W1551640722","https://openalex.org/W1902391833","https://openalex.org/W1969359829","https://openalex.org/W1975272969","https://openalex.org/W1976275939","https://openalex.org/W1978673398","https://openalex.org/W2005688553","https://openalex.org/W2010335941","https://openalex.org/W2027404394","https://openalex.org/W2046199669","https://openalex.org/W2058594923","https://openalex.org/W2073851211","https://openalex.org/W2083436341","https://openalex.org/W2104813838","https://openalex.org/W2132201748","https://openalex.org/W2138294550","https://openalex.org/W2171171939","https://openalex.org/W2179194340","https://openalex.org/W2186641005","https://openalex.org/W2197523508","https://openalex.org/W2472216744","https://openalex.org/W4236538791","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W4253972002","https://openalex.org/W1978673398","https://openalex.org/W2073851211","https://openalex.org/W2373995568","https://openalex.org/W4323971695","https://openalex.org/W2578920086","https://openalex.org/W2386371056","https://openalex.org/W2372444583","https://openalex.org/W2376739319","https://openalex.org/W4396626053"],"abstract_inverted_index":{"Background:":[0],"Osteonecrosis":[1],"of":[2,14,21,28,40,58,64,77,86,103,114,169,179,216,238,255],"the":[3,22,26,59,62,67,84,87,92,97,100,108,115,145,156,164,176,180,186,217,226,236,239,256],"femoral":[4,23,78,229,240],"head":[5,24,79,241],"is":[6],"a":[7,212,261],"debilitating":[8],"condition":[9,85],"characterized":[10],"by":[11],"progressive":[12],"degeneration":[13,142],"bone":[15],"that":[16,172,193,196,228],"eventually":[17],"leads":[18],"to":[19,225,234],"collapse":[20,65,80],"in":[25,37,43,163,205,245],"majority":[27],"patients.":[29,267],"Femoral":[30],"head-sparing":[31,230],"procedures":[32],"have":[33,53,243],"been":[34],"more":[35],"successful":[36],"pre-collapse":[38],"stages":[39],"osteonecrosis":[41],"than":[42],"post-collapse":[44,51,104],"stages,":[45],"although":[46],"some":[47,246],"patients":[48,206,247],"with":[49,120,124,144,175,185,207,248],"early":[50],"disease":[52],"had":[54],"no":[55,152],"additional":[56],"progression":[57],"disorder.":[60],"Nevertheless,":[61],"effects":[63],"on":[66],"articular":[68,88,105,116,194,257],"cartilage":[69,106,117,133,181,195,258],"are":[70],"not":[71,82,184],"well":[72],"understood,":[73],"and":[74,107,111,127,137,166],"radiographic":[75,214],"staging":[76],"does":[81],"address":[83],"cartilage.":[89],"Methods:":[90],"In":[91],"current":[93],"study,":[94],"we":[95],"investigated":[96],"relationship":[98],"between":[99,155],"mechanical":[101,167],"properties":[102,168],"histologic":[109,165],"findings":[110,222],"macroscopic":[112],"grades":[113],"from":[118,134],"hips":[119,139],"stage-IV":[121,136],"osteonecrosis,":[122,126],"those":[123,128,266],"stage-V":[125,138],"without":[129],"osteonecrosis.":[130],"Results:":[131],"The":[132,252],"both":[135],"showed":[140],"significant":[141,153,161],"compared":[143],"normal":[146,199],"control":[147],"cartilage,":[148],"but":[149,183],"there":[150],"was":[151,160],"difference":[154],"two":[157],"stages.":[158],"There":[159],"variability":[162],"these":[170],"samples":[171],"correlated":[173],"strongly":[174],"gross":[177,253],"appearance":[178,254],"surface":[182],"lesion":[187],"size.":[188],"Conclusions:":[189],"These":[190,221],"results":[191],"suggest":[192],"appears":[197],"macroscopically":[198],"may":[200,242,259],"remain":[201],"mechanically":[202],"functional":[203],"even":[204],"large":[208],"osteonecrotic":[209,250],"lesions":[210],"or":[211],"late":[213],"stage":[215],"disease.":[218,251],"Clinical":[219],"Relevance:":[220],"lend":[223],"support":[224],"position":[227],"surgical":[231],"strategies":[232],"designed":[233],"restore":[235],"contour":[237],"utility":[244],"advanced":[249],"be":[260],"useful":[262],"tool":[263],"for":[264],"identifying":[265]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}