{"id":"https://openalex.org/W2058714994","doi":"https://doi.org/10.1021/bi001290z","title":"Structural and Functional Implications of Tau Hyperphosphorylation: Information from Phosphorylation-Mimicking Mutated Tau Proteins","display_name":"Structural and Functional Implications of Tau Hyperphosphorylation: Information from Phosphorylation-Mimicking Mutated Tau Proteins","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2058714994","doi":"https://doi.org/10.1021/bi001290z","mag":"2058714994","pmid":"https://pubmed.ncbi.nlm.nih.gov/11052669"},"language":"en","primary_location":{"id":"doi:10.1021/bi001290z","doi":"https://doi.org/10.1021/bi001290z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi001290z","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070946569","display_name":"Jochen Eidenm\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jochen Eidenm\u00fcller","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062184288","display_name":"Thomas Fath","orcid":"https://orcid.org/0000-0002-6877-7567","observed_orcids":["https://orcid.org/0000-0002-6877-7567"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Thomas Fath","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048267255","display_name":"Andrea Hellwig","orcid":"https://orcid.org/0000-0002-5971-0862","observed_orcids":["https://orcid.org/0000-0002-5971-0862"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Andrea Hellwig","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111920087","display_name":"Jennifer Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jennifer Reed","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064294443","display_name":"Estelle Sontag","orcid":"https://orcid.org/0000-0001-7717-7670","observed_orcids":["https://orcid.org/0000-0001-7717-7670"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Estelle Sontag","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023704791","display_name":"Roland Brandt","orcid":"https://orcid.org/0000-0003-0101-1257","observed_orcids":["https://orcid.org/0000-0003-0101-1257","https://orcid.org/0009-0006-5842-4254"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Roland Brandt","raw_affiliation_strings":["Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, IZN, University of Heidelberg, INF 345, 69120 Heidelberg, Germany, Department of Pathochemistry, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 73235","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023704791"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I867280407"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.6296,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.82441664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"39","issue":"43","first_page":"13166","last_page":"13175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.703000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glutamate-substitution","display_name":"glutamate substitution","score":0.8980000019073486},{"id":"https://openalex.org/keywords/paired-helical-filaments","display_name":"paired helical filaments","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microtubule-nucleation","display_name":"microtubule nucleation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.949999988079071},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.8591317534446716},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7082957029342651},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6821497678756714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4756447970867157},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4156852960586548},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3460240364074707},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33563297986984253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3081182837486267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30526313185691833},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2121889591217041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19449719786643982},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12600719928741455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10731148719787598}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi001290z","doi":"https://doi.org/10.1021/bi001290z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi001290z","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11052669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11052669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2594061558","display_name":"Neurobiology of Alzheimer's Disease and Aging","funder_award_id":"P30AG012300","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W126426573","https://openalex.org/W1482198038","https://openalex.org/W1525659758","https://openalex.org/W1531327859","https://openalex.org/W1773591497","https://openalex.org/W1958842451","https://openalex.org/W1978668412","https://openalex.org/W1984482388","https://openalex.org/W1986537744","https://openalex.org/W1994030229","https://openalex.org/W2022969837","https://openalex.org/W2037968918","https://openalex.org/W2040351396","https://openalex.org/W2043924172","https://openalex.org/W2048460609","https://openalex.org/W2049087686","https://openalex.org/W2060289280","https://openalex.org/W2061655823","https://openalex.org/W2073235859","https://openalex.org/W2078658743","https://openalex.org/W2090793855","https://openalex.org/W2093992870","https://openalex.org/W2157124870","https://openalex.org/W2162297135"],"related_works":["https://openalex.org/W1999629716","https://openalex.org/W2066610668","https://openalex.org/W2156093068","https://openalex.org/W2148484454","https://openalex.org/W7167831271","https://openalex.org/W1969979382","https://openalex.org/W2915622491","https://openalex.org/W4407745018","https://openalex.org/W2151397539","https://openalex.org/W2583755919"],"abstract_inverted_index":{"Abnormal":[0],"tau-immunoreactive":[1],"filaments":[2,51],"are":[3],"a":[4,22,62,92,141,187,214,222,230],"hallmark":[5],"of":[6,17,30,110,176,195,217],"tauopathies,":[7,211],"including":[8],"Alzheimer's":[9],"disease":[10],"(AD).":[11],"A":[12],"higher":[13],"phosphorylation":[14],"(\"hyperphosphorylation\")":[15],"state":[16],"tau":[18,31,37,50,67,85,89,125,150,153,164,184,196,207,219],"protein":[19,134],"may":[20],"represent":[21],"critical":[23],"event.":[24],"To":[25],"determine":[26],"the":[27,111,131,162,170,192,205],"potential":[28],"role":[29],"hyperphosphorylation":[32],"in":[33,49,84,96,212,225],"these":[34],"disorders,":[35],"mutated":[36,163],"proteins":[38,90,126,185],"were":[39,56],"produced":[40],"where":[41],"serine/threonine":[42],"residues":[43],"known":[44],"to":[45,60,99,119,128,144,156,204,232],"be":[46,106],"highly":[47],"phosphorylated":[48,120],"isolated":[52],"from":[53,169,220],"AD":[54],"patients":[55],"substituted":[57],"for":[58,190],"glutamate":[59,74],"simulate":[61],"paired":[63],"helical":[64],"filament":[65],"(PHF)-like":[66],"hyperphosphorylation.":[68,197],"We":[69],"demonstrate":[70],"that,":[71],"like":[72],"hyperphosphorylation,":[73],"substitutions":[75],"induce":[76],"compact":[77],"structure":[78],"elements":[79],"and":[80,139,151,229],"SDS-resistant":[81],"conformational":[82],"domains":[83],"protein.":[86],"Hyperphosphorylation-mimicking":[87],"glutamate-mutated":[88,124,183],"display":[91],"complete":[93],"functional":[94,193,223],"loss":[95,224],"its":[97],"ability":[98,143],"promote":[100],"microtubule":[101,171,227],"nucleation":[102],"which":[103,116],"can":[104],"partially":[105],"overcome":[107],"by":[108,173],"addition":[109],"osmolyte":[112],"trimethylamine":[113],"N-oxide":[114],"(TMAO),":[115],"is":[117,165],"similar":[118],"tau.":[121,178],"In":[122],"addition,":[123],"fail":[127],"interact":[129,233],"with":[130,234],"dominant":[132],"brain":[133],"phosphatase":[135],"2A":[136],"isoform":[137],"ABalphaC,":[138],"exhibit":[140],"reduced":[142],"assemble":[145],"into":[146],"filaments.":[147],"Interestingly,":[148],"wild-type":[149,177],"phosphorylation-mimicking":[152],"similarly":[154],"bind":[155],"microtubules":[157],"when":[158],"added":[159],"alone,":[160],"but":[161],"almost":[166],"completely":[167],"displaced":[168],"surface":[172],"equimolar":[174],"concentrations":[175],"The":[179],"data":[180],"indicate":[181],"that":[182,200],"provide":[186],"useful":[188],"model":[189],"analyzing":[191],"consequences":[194],"They":[198],"suggest":[199],"several":[201],"mechanisms":[202],"contribute":[203],"abnormal":[206],"accumulation":[208],"observed":[209],"during":[210],"particular":[213],"selective":[215],"displacement":[216],"hyperphosphorylated":[218],"microtubules,":[221],"promoting":[226],"nucleation,":[228],"failure":[231],"phosphatases.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
