{"id":"https://openalex.org/W2058711306","doi":"https://doi.org/10.2165/10558450-000000000-00000","title":"Safety of the Combination of Intensive Cholesterol-Lowering Therapy with Oral Anticoagulation Medication in Elderly Patients with Atrial Fibrillation","display_name":"Safety of the Combination of Intensive Cholesterol-Lowering Therapy with Oral Anticoagulation Medication in Elderly Patients with Atrial Fibrillation","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W2058711306","doi":"https://doi.org/10.2165/10558450-000000000-00000","mag":"2058711306","pmid":"https://pubmed.ncbi.nlm.nih.gov/19655825"},"language":"en","primary_location":{"id":"doi:10.2165/10558450-000000000-00000","doi":"https://doi.org/10.2165/10558450-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/10558450-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S37256505","display_name":"Drugs & Aging","issn_l":"1170-229X","issn":["1170-229X","1179-1969"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs &amp; Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015977083","display_name":"Morteza Enajat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Morteza Enajat","raw_affiliation_strings":["Heart Centre, St Radboud University Medical Centre, Nijmegen, the Netherlands. m.enajat@live.nl","Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Centre, St Radboud University Medical Centre, Nijmegen, the Netherlands. m.enajat@live.nl","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037625836","display_name":"Steven Teerenstra","orcid":"https://orcid.org/0000-0003-4103-7451","observed_orcids":["https://orcid.org/0000-0003-4103-7451"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Steven Teerenstra","raw_affiliation_strings":["Department of Epidemiology, Biostatistics, and Health Technology Assessment, St Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Biostatistics, and Health Technology Assessment, St Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111425273","display_name":"Janet T. van Kuilenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janet T. van Kuilenburg","raw_affiliation_strings":["Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032468643","display_name":"Aty H van Sorge-Greve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aty H.N. van Sorge-Greve","raw_affiliation_strings":["Anticoagulation Outpatient Clinic, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anticoagulation Outpatient Clinic, Nijmegen, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084253125","display_name":"Marjo T Albers-Akkers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marjo T.H. Albers-Akkers","raw_affiliation_strings":["Anticoagulation Outpatient Clinic, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anticoagulation Outpatient Clinic, Nijmegen, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065978967","display_name":"Freek W.A. Verheugt","orcid":"https://orcid.org/0000-0002-5831-6951","observed_orcids":["https://orcid.org/0000-0002-5831-6951","https://orcid.org/0000-0003-0373-0028"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Freek W.A. Verheugt","raw_affiliation_strings":["Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103439796","display_name":"Gheorghe A.M. Pop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gheorghe A.M. Pop","raw_affiliation_strings":["Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Heart Lung Center, St Radboud University Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015977083"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.8463,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77362493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"26","issue":"7","first_page":"585","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cholesterol-lowering-therapy","display_name":"cholesterol-lowering therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":1.0},{"id":"https://openalex.org/keywords/statin-drug-interactions","display_name":"statin-drug interactions","score":0.7730000019073486},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7509999871253967},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5569999814033508},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9515930414199829},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.7837550044059753},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6859046816825867},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6797201633453369},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.6274956464767456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6149008870124817},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5441878437995911},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4729751646518707},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.44635188579559326},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4287532567977905},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.42599090933799744},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.41313838958740234},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.41174134612083435},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015990","descriptor_name":"Placebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023381","descriptor_name":"Endpoint Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2165/10558450-000000000-00000","doi":"https://doi.org/10.2165/10558450-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/10558450-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S37256505","display_name":"Drugs & Aging","issn_l":"1170-229X","issn":["1170-229X","1179-1969"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs &amp; Aging","raw_type":"journal-article"},{"id":"pmid:19655825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19655825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs & aging","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/81622","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/81622","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/81622","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/81622","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drugs &amp; Aging, 26, 585 - 93","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1546258268","https://openalex.org/W1969464487","https://openalex.org/W1987507883","https://openalex.org/W1992084132","https://openalex.org/W2002405990","https://openalex.org/W2010518325","https://openalex.org/W2023647455","https://openalex.org/W2024581697","https://openalex.org/W2045913143","https://openalex.org/W2059665864","https://openalex.org/W2074022399","https://openalex.org/W2114775432","https://openalex.org/W2118036010","https://openalex.org/W2155270329","https://openalex.org/W2158454439","https://openalex.org/W2168876694","https://openalex.org/W4206535002","https://openalex.org/W4233664165"],"related_works":["https://openalex.org/W2322840986","https://openalex.org/W3017771646","https://openalex.org/W4283688536","https://openalex.org/W2030219522","https://openalex.org/W2385363461","https://openalex.org/W3132713481","https://openalex.org/W2158834148","https://openalex.org/W2792709680","https://openalex.org/W2885400827","https://openalex.org/W4416308216"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
