{"id":"https://openalex.org/W2058710765","doi":"https://doi.org/10.1007/s11033-011-1059-9","title":"Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture","display_name":"Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture","publication_year":2011,"publication_date":"2011-06-20","ids":{"openalex":"https://openalex.org/W2058710765","doi":"https://doi.org/10.1007/s11033-011-1059-9","mag":"2058710765","pmid":"https://pubmed.ncbi.nlm.nih.gov/21691708"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-011-1059-9","doi":"https://doi.org/10.1007/s11033-011-1059-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-011-1059-9","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101595491","display_name":"Yang Cao","orcid":"https://orcid.org/0000-0002-3695-3992","observed_orcids":["https://orcid.org/0000-0002-3695-3992"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Cao","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang 150001, People's Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang 150001, People's Republic of China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445420","display_name":"Dawei Wang","orcid":"https://orcid.org/0000-0001-8410-5237","observed_orcids":["https://orcid.org/0000-0001-8410-5237","https://orcid.org/0000-0003-2482-9588"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dawei Wang","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111776235","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0001-7518-7867","observed_orcids":["https://orcid.org/0000-0001-7518-7867"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guijun Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guijun Yao","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082748585","display_name":"Yutuo Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutuo Fu","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632741","display_name":"Zhenggang Bi","orcid":"https://orcid.org/0000-0002-5057-1341","observed_orcids":["https://orcid.org/0000-0002-5057-1341"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenggang Bi","raw_affiliation_strings":["Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","First affiliated hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210156501"]},{"raw_affiliation_string":"First affiliated hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100632741"],"corresponding_institution_ids":["https://openalex.org/I4210156501"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.3356,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6889835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"39","issue":"3","first_page":"2975","last_page":"2979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/comt-val158met-polymorphism","display_name":"COMT Val158Met polymorphism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/osteoporotic-fractures","display_name":"osteoporotic fractures","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hip-fracture","display_name":"hip fracture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6639999747276306},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.7590000033378601},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.6869999766349792},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.8540267944335938},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7546053528785706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6932989954948425},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6713483333587646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6262056231498718},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5624886751174927},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5279442667961121},{"id":"https://openalex.org/C2994343686","wikidata":"https://www.wikidata.org/wiki/Q1753467","display_name":"Osteoporotic fracture","level":4,"score":0.5135019421577454},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.510877788066864},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4847528636455536},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4415488541126251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3593086004257202},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.35848861932754517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23164325952529907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17277973890304565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09015876054763794}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058866","descriptor_name":"Osteoporotic Fractures","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D058866","descriptor_name":"Osteoporotic Fractures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-011-1059-9","doi":"https://doi.org/10.1007/s11033-011-1059-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-011-1059-9","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:21691708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21691708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W85173172","https://openalex.org/W1933024589","https://openalex.org/W1963976688","https://openalex.org/W1965183927","https://openalex.org/W1970871071","https://openalex.org/W2000614513","https://openalex.org/W2000657664","https://openalex.org/W2002667743","https://openalex.org/W2002924471","https://openalex.org/W2028355948","https://openalex.org/W2035153654","https://openalex.org/W2044572703","https://openalex.org/W2044908713","https://openalex.org/W2048450287","https://openalex.org/W2057646888","https://openalex.org/W2060600329","https://openalex.org/W2065892471","https://openalex.org/W2082233939","https://openalex.org/W2086083847","https://openalex.org/W2088504456","https://openalex.org/W2090413498","https://openalex.org/W2100040984","https://openalex.org/W2131214643","https://openalex.org/W2141496371","https://openalex.org/W2157388990","https://openalex.org/W2163072567","https://openalex.org/W2168994952","https://openalex.org/W2415379565","https://openalex.org/W2418130305","https://openalex.org/W2994602735"],"related_works":["https://openalex.org/W2094444237","https://openalex.org/W2116328232","https://openalex.org/W2044572703","https://openalex.org/W155647672","https://openalex.org/W94947200","https://openalex.org/W7097753884","https://openalex.org/W2077453818","https://openalex.org/W1522174436","https://openalex.org/W3030699986","https://openalex.org/W3031642527"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}