{"id":"https://openalex.org/W2058697232","doi":"https://doi.org/10.3109/10428190109058002","title":"Primary Effusion Lymphoma (PEL) in HIV-Negative Patients - a Distinct Clinical Entity","display_name":"Primary Effusion Lymphoma (PEL) in HIV-Negative Patients - a Distinct Clinical Entity","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2058697232","doi":"https://doi.org/10.3109/10428190109058002","mag":"2058697232","pmid":"https://pubmed.ncbi.nlm.nih.gov/11378560"},"language":"en","primary_location":{"id":"doi:10.3109/10428190109058002","doi":"https://doi.org/10.3109/10428190109058002","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428190109058002","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112196034","display_name":"Abraham Klepfish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Abraham Klepfish","raw_affiliation_strings":["Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot Jerusalem. klepfish@zahav.net.il","Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot Jerusalem. klepfish@zahav.net.il","institution_ids":["https://openalex.org/I2800052317"]},{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086070151","display_name":"Ronit Sarid","orcid":"https://orcid.org/0000-0001-8658-0453","observed_orcids":["https://orcid.org/0000-0001-8658-0453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronit Sarid","raw_affiliation_strings":["Faculty of Life Sciences, Bar-Han University, Kamat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, Bar-Han University, Kamat Gan, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568613","display_name":"Mordechai Shtalrid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mordechai Shtalrid","raw_affiliation_strings":["Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090335644","display_name":"Lev Shvidel","orcid":"https://orcid.org/0000-0002-0398-9390","observed_orcids":["https://orcid.org/0000-0002-0398-9390"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lev Shvidel","raw_affiliation_strings":["Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113540166","display_name":"Alan Berrebi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alan Berrebi","raw_affiliation_strings":["Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075785977","display_name":"Ami Schattner","orcid":"https://orcid.org/0000-0002-1413-8858","observed_orcids":["https://orcid.org/0000-0002-1413-8858"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I2800052317","display_name":"Kaplan Medical Center","ror":"https://ror.org/00t0n9020","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800052317","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ami Schattner","raw_affiliation_strings":["Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematology Institute and Department of Medicine, Kaplan Medical Centre, Rehovot and the Hebrew University-Hadassah School of Medicine, Jerusalem","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112196034"],"corresponding_institution_ids":["https://openalex.org/I197251160","https://openalex.org/I2800052317"],"apc_list":null,"apc_paid":null,"fwci":2.7959,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.90319055,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"3-4","first_page":"439","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-effusion-lymphoma","display_name":"primary effusion lymphoma","score":1.0},{"id":"https://openalex.org/keywords/hiv-negative-patients","display_name":"HIV-negative patients","score":0.8450000286102295},{"id":"https://openalex.org/keywords/human-herpesvirus-8","display_name":"human herpesvirus 8","score":0.8640000224113464},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.7879999876022339},{"id":"https://openalex.org/keywords/complete-clinical-remission","display_name":"complete clinical remission","score":0.8849999904632568},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779594685","wikidata":"https://www.wikidata.org/wiki/Q3832899","display_name":"Primary effusion lymphoma","level":3,"score":0.9318702220916748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8144320249557495},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7806905508041382},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.5478335618972778},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5263789296150208},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.47621116042137146},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4211677014827728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2516331672668457}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002637","descriptor_name":"Chest Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016066","descriptor_name":"Pleural Effusion, Malignant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016066","descriptor_name":"Pleural Effusion, Malignant","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016066","descriptor_name":"Pleural Effusion, Malignant","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018023","descriptor_name":"HIV Seronegativity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10428190109058002","doi":"https://doi.org/10.3109/10428190109058002","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428190109058002","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia &amp; Lymphoma","raw_type":"journal-article"},{"id":"pmid:11378560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11378560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & lymphoma","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W323508686","https://openalex.org/W1501718277","https://openalex.org/W1558279218","https://openalex.org/W1787380229","https://openalex.org/W1971747393","https://openalex.org/W2014571799","https://openalex.org/W2017262073","https://openalex.org/W2032438721","https://openalex.org/W2065850953","https://openalex.org/W2108790901","https://openalex.org/W2111830049","https://openalex.org/W2154819235","https://openalex.org/W2160508776","https://openalex.org/W2336241188","https://openalex.org/W2467833497"],"related_works":["https://openalex.org/W2416585393","https://openalex.org/W2356909179","https://openalex.org/W1968086135","https://openalex.org/W2995591574","https://openalex.org/W4408627994","https://openalex.org/W3086589176","https://openalex.org/W1969420095","https://openalex.org/W2041439959","https://openalex.org/W2024419546","https://openalex.org/W7095202677"],"abstract_inverted_index":{"Primary":[0],"effusion":[1],"lymphoma":[2,12,75,91],"(PEL)":[3],"is":[4],"a":[5,30,97,117,192],"recently":[6],"described":[7],"rare":[8,184],"type":[9],"of":[10,40,73,109,124,154,172,182,212],"non-Hodgkin's":[11],"occurring":[13],"almost":[14],"exclusively":[15],"in":[16,49,116,147,178,209],"HIV":[17],"infected":[18],"people.":[19],"Human":[20],"herpesvirus":[21],"8":[22],"(HHV-8),":[23],"has":[24,33,46],"been":[25,34,47,176],"linked":[26],"with":[27,64,90,96,101,164,196],"PEL,":[28],"and":[29,68,79,113,152,166,202],"causative":[31],"relationship":[32],"suggested.":[35],"In":[36],"the":[37,50,107,110,135,179,210],"vast":[38],"majority":[39],"PEL":[41,189],"cases":[42,163,185],"Epstein-Barr":[43],"virus":[44],"(EBV)":[45],"found":[48],"tumour":[51],"cells.":[52],"We":[53],"describe":[54],"here":[55],"an":[56,155,204],"elderly":[57],"human":[58],"immune":[59],"deficiency":[60],"(HIV)":[61],"seronegative":[62],"man":[63],"intractable":[65],"chest":[66,111],"pain":[67,112],"pleural":[69,83],"effusion.":[70],"The":[71,122,144],"diagnosis":[72],"malignant":[74],"was":[76,92,126,142],"suggested":[77],"cytologically":[78],"confirmed":[80],"histologically":[81],"following":[82],"biopsy.":[84],"No":[85],"lymphadenopathy":[86],"or":[87],"organ":[88],"involvement":[89],"found.":[93],"Systemic":[94],"chemotherapy":[95],"modified":[98],"CHOP":[99],"regimen":[100],"G-CSF":[102],"support":[103],"gradually":[104],"led":[105],"to":[106,170,190],"resolution":[108],"ultimately":[114],"resulted":[115],"complete":[118],"clinical":[119,165,194],"remission":[120],"(CCR).":[121],"presence":[123],"HHV-8":[125,208],"demonstrated":[127],"by":[128],"PCR":[129],"using":[130],"paraffin-embedded":[131],"tissue":[132],"samples":[133],"from":[134],"involved":[136],"pleura,":[137],"whereas":[138],"EBV-associated":[139],"genetic":[140],"material":[141],"absent.":[143],"patient":[145,174],"remained":[146],"CCR":[148],"for":[149,207],"18":[150],"months":[151],"died":[153],"unrelated":[156],"cause":[157],"(cerebrovascular":[158],"event).":[159],"Only":[160],"11":[161],"other":[162],"virological":[167],"features":[168,198],"similar":[169],"those":[171],"our":[173],"have":[175],"reported":[177],"literature.":[180],"Analysis":[181],"these":[183],"suggests":[186],"HIV-negative":[187],"EBV-negative":[188],"be":[191],"distinct":[193],"entity":[195],"epidemiological":[197],"resembling":[199],"classical":[200],"KS":[201],"supports":[203],"EBV-independent":[205],"role":[206],"pathogenesis":[211],"PEL.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
