{"id":"https://openalex.org/W2058679792","doi":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","title":"Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients","display_name":"Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients","publication_year":2004,"publication_date":"2004-08-10","ids":{"openalex":"https://openalex.org/W2058679792","doi":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","mag":"2058679792","pmid":"https://pubmed.ncbi.nlm.nih.gov/15304117"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1746.2004.03429.x","doi":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109357036","display_name":"Takaaki Mizushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"TAKAAKI MIZUSHIMA","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan. takaakim@cc.okayama-u.ac.jp","Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan. takaakim@cc.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110473017","display_name":"Koji Ochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOJI OCHI","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032233437","display_name":"Mitsuko Ichimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MITSUKO ICHIMURA","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700160","display_name":"Katsuyuki Kiura","orcid":"https://orcid.org/0000-0002-9172-9379","observed_orcids":["https://orcid.org/0000-0002-9172-9379"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KATSUYUKI KIURA","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"HIDEO HARADA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEO HARADA","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102401517","display_name":"Norio Koide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIO KOIDE","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109357036"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":1.432,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.81979366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"9","first_page":"1005","last_page":"1009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pancreatic-enzyme-replacement-therapy","display_name":"pancreatic enzyme replacement therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.6759999990463257},{"id":"https://openalex.org/keywords/gallbladder-contraction","display_name":"gallbladder contraction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gastric-dysmotility","display_name":"gastric dysmotility","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pancreatic-polypeptide","display_name":"pancreatic polypeptide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/exocrine-pancreatic-insufficiency","display_name":"exocrine pancreatic insufficiency","score":0.8289999961853027},{"id":"https://openalex.org/keywords/test-meal","display_name":"test meal","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8430807590484619},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.810372531414032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7779141664505005},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.7680262327194214},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7572925090789795},{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.7026817202568054},{"id":"https://openalex.org/C2778108375","wikidata":"https://www.wikidata.org/wiki/Q246978","display_name":"Pancreatic polypeptide","level":4,"score":0.5507833957672119},{"id":"https://openalex.org/C2777148285","wikidata":"https://www.wikidata.org/wiki/Q64386","display_name":"Gallbladder","level":2,"score":0.5371028184890747},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.5281115770339966},{"id":"https://openalex.org/C3019860435","wikidata":"https://www.wikidata.org/wiki/Q419557","display_name":"Pancreatic enzymes","level":3,"score":0.4613734483718872},{"id":"https://openalex.org/C57380142","wikidata":"https://www.wikidata.org/wiki/Q863089","display_name":"Pancreatic juice","level":3,"score":0.4605068564414978},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.4362427592277527},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3959650695323944},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.3923434317111969},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.31088295578956604},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.0487176775932312},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.047691911458969116}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010184","descriptor_name":"Pancreatic Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010186","descriptor_name":"Pancreatic Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016473","descriptor_name":"Gallbladder Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1746.2004.03429.x","doi":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2004.03429.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:15304117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15304117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W106498175","https://openalex.org/W141786692","https://openalex.org/W1480497502","https://openalex.org/W1540182701","https://openalex.org/W1749428915","https://openalex.org/W1973789314","https://openalex.org/W1978899781","https://openalex.org/W1979515954","https://openalex.org/W1981732424","https://openalex.org/W2022406486","https://openalex.org/W2025669357","https://openalex.org/W2027106073","https://openalex.org/W2032643384","https://openalex.org/W2053725221","https://openalex.org/W2090467991","https://openalex.org/W2114526395","https://openalex.org/W2140762297","https://openalex.org/W2142293392","https://openalex.org/W2142893972","https://openalex.org/W2145609865","https://openalex.org/W2157094152","https://openalex.org/W2187950837","https://openalex.org/W2404866367","https://openalex.org/W2414990861","https://openalex.org/W2418064632","https://openalex.org/W2467526165"],"related_works":["https://openalex.org/W1749428915","https://openalex.org/W1517780233","https://openalex.org/W2117966639","https://openalex.org/W2467526165","https://openalex.org/W1981732424","https://openalex.org/W2114526395","https://openalex.org/W2027106073","https://openalex.org/W1988361876","https://openalex.org/W1997134654","https://openalex.org/W1978899781"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Impaired":[3],"gallbladder":[4,56,114,168],"contraction":[5,57,115,169],"and":[6,47,55,83,95,130,145,158],"rapid":[7],"gastric":[8,52,125,155,185],"emptying":[9,53,126,156],"in":[10],"patients":[11,43,61,110],"with":[12,44,80,111],"chronic":[13,45,112],"pancreatitis":[14,46],"may":[15],"be":[16],"the":[17,33,99,104,120,131,154,159,167,179,184,188,193,199],"result":[18],"of":[19,41,87,133,149],"depleted":[20,194],"pancreatic":[21,29,70,88,105,137,160,181,195],"exocrine":[22],"function.":[23],"The":[24,51,124],"authors":[25],"tested":[26],"whether":[27],"oral":[28,150,180],"enzymes":[30,151,182],"can":[31],"improve":[32,166],"dysmotility":[34],"or":[35],"not.":[36],"METHODS:":[37],"Study":[38],"subjects":[39],"consisted":[40],"15":[42,117,172],"18":[48],"healthy":[49],"controls.":[50],"time":[54,127,157],"were":[58,62,92],"studied.":[59],"All":[60],"initially":[63],"studied":[64],"using":[65],"a":[66,77,81,84,146],"test":[67,78,100],"meal":[68,79,101,121],"without":[69],"enzymes,":[71],"followed":[72],"on":[73],"separate":[74],"days":[75],"by":[76],"single":[82,143],"triple":[85,147],"dose":[86,144,148],"enzymes.":[89],"Blood":[90],"samples":[91],"taken":[93],"before":[94],"2":[96],"h":[97],"after":[98,119],"to":[102,135],"determine":[103],"polypeptide":[106,138,161],"levels.":[107],"RESULTS:":[108],"In":[109],"pancreatitis,":[113],"at":[116,171],"min":[118],"was":[122,128,140,176],"impaired.":[123],"faster":[129],"ratio":[132],"pre-":[134],"postprandial":[136],"levels":[139],"enhanced.":[141],"A":[142],"further":[152],"improved":[153,183],"ration,":[162],"but":[163],"did":[164],"not":[165],"rate":[170],"min.":[173],"CONCLUSIONS:":[174],"It":[175],"demonstrated":[177],"that":[178,191],"dysmotility,":[186],"confirming":[187],"previous":[189],"findings":[190],"suggested":[192],"enzyme":[196],"output":[197],"caused":[198],"dysmotility.":[200]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
