{"id":"https://openalex.org/W2058639735","doi":"https://doi.org/10.1242/dev.00598","title":"Targeted expression ofshibirets andsemaphorin 1areveals critical periods for synapse formation in the giant fiber ofDrosophila","display_name":"Targeted expression ofshibirets andsemaphorin 1areveals critical periods for synapse formation in the giant fiber ofDrosophila","publication_year":2003,"publication_date":"2003-06-30","ids":{"openalex":"https://openalex.org/W2058639735","doi":"https://doi.org/10.1242/dev.00598","mag":"2058639735","pmid":"https://pubmed.ncbi.nlm.nih.gov/12835384"},"language":"en","primary_location":{"id":"doi:10.1242/dev.00598","doi":"https://doi.org/10.1242/dev.00598","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00598","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/16/3671/1496399/3671.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/dev/article-pdf/130/16/3671/1496399/3671.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108961540","display_name":"R. K. Murphey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. K. Murphey","raw_affiliation_strings":["University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, MA 01003 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, MA 01003 USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018237422","display_name":"Stephan J. Froggett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan J. Froggett","raw_affiliation_strings":["University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Phyllis Caruccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phyllis Caruccio","raw_affiliation_strings":["University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081530006","display_name":"Xiaoliang Shan-Crofts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoliang Shan-Crofts","raw_affiliation_strings":["University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073473042","display_name":"Toshihiro Kitamoto","orcid":"https://orcid.org/0000-0003-0863-8466","observed_orcids":["https://orcid.org/0000-0003-0863-8466"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihiro Kitamoto","raw_affiliation_strings":["Division of Neurosciences, Beckman Research Institute of the City of Hope,1450 E.Duarte Road, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosciences, Beckman Research Institute of the City of Hope,1450 E.Duarte Road, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020894647","display_name":"Tanja Angela Godenschwege","orcid":"https://orcid.org/0000-0003-3322-4134","observed_orcids":["https://orcid.org/0000-0003-3322-4134"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja A. Godenschwege","raw_affiliation_strings":["University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts, Department of Biology, Morrill Science Center,Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108961540"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":0.5769,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.5721465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"130","issue":"16","first_page":"3671","last_page":"3682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giant-fiber","display_name":"giant fiber","score":0.7720000147819519},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/shibire","display_name":"shibire","score":0.7099999785423279},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.8410000205039978},{"id":"https://openalex.org/keywords/synapse-stabilization","display_name":"synapse stabilization","score":0.8040000200271606},{"id":"https://openalex.org/keywords/critical-period","display_name":"critical period","score":0.5009999871253967},{"id":"https://openalex.org/keywords/neural-circuit-assembly","display_name":"neural circuit assembly","score":0.6759999990463257},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7409999966621399},{"id":"https://openalex.org/keywords/temperature-sensitive-mutants","display_name":"temperature-sensitive mutants","score":0.5189999938011169},{"id":"https://openalex.org/keywords/axon-retraction","display_name":"axon retraction","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.9506178498268127},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.9043606519699097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.881119430065155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7116329073905945},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6617017388343811},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.6119412779808044},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6056115627288818},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4521489441394806},{"id":"https://openalex.org/C2779841796","wikidata":"https://www.wikidata.org/wiki/Q1188964","display_name":"Plexin","level":4,"score":0.4472280740737915},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.4277235269546509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.151216059923172},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1327316164970398},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08331707119941711}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.00598","doi":"https://doi.org/10.1242/dev.00598","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00598","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/16/3671/1496399/3671.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:12835384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12835384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1242/dev.00598","doi":"https://doi.org/10.1242/dev.00598","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00598","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/16/3671/1496399/3671.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8625312742","display_name":"SEMAPHORIN 1A AND GIANT SYNAPSE FORMATION IN DROSOPHILA","funder_award_id":"R01NS044609","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058639735.pdf","grobid_xml":"https://content.openalex.org/works/W2058639735.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1480515133","https://openalex.org/W1492722920","https://openalex.org/W1516035770","https://openalex.org/W1526145742","https://openalex.org/W1551832520","https://openalex.org/W1553437553","https://openalex.org/W1605714019","https://openalex.org/W1856652139","https://openalex.org/W1955421306","https://openalex.org/W1966903404","https://openalex.org/W1979060547","https://openalex.org/W1991673450","https://openalex.org/W1996224026","https://openalex.org/W1997467265","https://openalex.org/W1998105194","https://openalex.org/W2014263971","https://openalex.org/W2042524484","https://openalex.org/W2044643509","https://openalex.org/W2055473408","https://openalex.org/W2058684340","https://openalex.org/W2073288679","https://openalex.org/W2080064596","https://openalex.org/W2088843431","https://openalex.org/W2094105661","https://openalex.org/W2106773196","https://openalex.org/W2107801352","https://openalex.org/W2131384342","https://openalex.org/W2151381548","https://openalex.org/W2160197139","https://openalex.org/W2166254371","https://openalex.org/W2167888543","https://openalex.org/W2169456271","https://openalex.org/W2418359239","https://openalex.org/W2797816625"],"related_works":["https://openalex.org/W37773722","https://openalex.org/W1955421306","https://openalex.org/W7011775503","https://openalex.org/W2088843431","https://openalex.org/W2109838606","https://openalex.org/W2160197139","https://openalex.org/W7006316884","https://openalex.org/W2169456271","https://openalex.org/W2080064596","https://openalex.org/W2578089249"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,25,60],"determine":[3],"the":[4,9,21,26,97,111,121],"timing":[5],"of":[6,11,20,71,96,110,117,120],"events":[7],"during":[8,37],"assembly":[10],"a":[12,73,79,107,132],"neural":[13],"circuit":[14],"in":[15],"Drosophila":[16],"we":[17,56,88],"targeted":[18,118],"expression":[19,119],"temperature-sensitive":[22],"shibire":[23],"gene":[24,124],"giant":[27,40,61],"fiber":[28,41,62],"system":[29],"and":[30,55,85,103],"then":[31],"disrupted":[32],"endocytosis":[33,49,102],"at":[34,52],"various":[35],"times":[36],"development.":[38],"The":[39],"retracted":[42],"its":[43,104],"axon":[44],"or":[45],"incipient":[46],"synapses":[47],"when":[48],"was":[50,94,106],"blocked":[51],"critical":[53],"times,":[54],"perceived":[57],"four":[58],"phases":[59],"development:":[63],"an":[64,68],"early":[65],"pathfinding":[66],"phase,":[67],"intermediate":[69],"phase":[70],"synaptogenesis,":[72],"late":[74],"stabilization":[75],"process":[76],"and,":[77],"finally,":[78],"mature":[80],"synapse.":[81],"By":[82],"co-expressing":[83],"shibire(ts)":[84],"semaphorin":[86,122],"1a":[87,93,123,130],"provided":[89],"evidence":[90],"that":[91,126],"Semaphorin":[92,129],"one":[95],"proteins":[98],"being":[99],"regulated":[100],"by":[101],"removal":[105],"necessary":[108],"part":[109],"program":[112],"for":[113],"synaptogenesis.":[114],"Temporal":[115],"control":[116],"showed":[125],"acute":[127],"excess":[128],"had":[131],"permanent":[133],"disruptive":[134],"effect":[135],"on":[136],"synapse":[137],"formation.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}