{"id":"https://openalex.org/W2058554459","doi":"https://doi.org/10.1210/endo.141.1.7229","title":"Dynamic Regulation of RGS2 in Bone: Potential New Insights into Parathyroid Hormone Signaling Mechanisms","display_name":"Dynamic Regulation of RGS2 in Bone: Potential New Insights into Parathyroid Hormone Signaling Mechanisms","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2058554459","doi":"https://doi.org/10.1210/endo.141.1.7229","mag":"2058554459","pmid":"https://pubmed.ncbi.nlm.nih.gov/10614620"},"language":"en","primary_location":{"id":"doi:10.1210/endo.141.1.7229","doi":"https://doi.org/10.1210/endo.141.1.7229","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.141.1.7229","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088374293","display_name":"Rebecca R. Miles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. R. Miles","raw_affiliation_strings":["Endocrine Division, Lilly Research Labs, Indianapolis, Indiana 46285, USA","Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division, Lilly Research Labs, Indianapolis, Indiana 46285, USA","institution_ids":["https://openalex.org/I168537998"]},{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066360902","display_name":"James Patrick Sluka","orcid":"https://orcid.org/0000-0002-5901-1404","observed_orcids":["https://orcid.org/0000-0002-5901-1404"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. P. Sluka","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066671604","display_name":"Robert F. Santerre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. F. Santerre","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007137068","display_name":"Laura V. Hale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. V. Hale","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026020672","display_name":"Laura J. Bloem","orcid":"https://orcid.org/0000-0002-5080-9655","observed_orcids":["https://orcid.org/0000-0002-5080-9655"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Bloem","raw_affiliation_strings":["Cardiovascular Division (L.B.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division (L.B.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047468774","display_name":"George Boguslawski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Boguslawski","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048019162","display_name":"Kannan Thirunavukkarasu","orcid":"https://orcid.org/0009-0000-1503-1529","observed_orcids":["https://orcid.org/0009-0000-1503-1529"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Thirunavukkarasu","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060025923","display_name":"Janet M. Hock","orcid":"https://orcid.org/0000-0001-8873-2545","observed_orcids":["https://orcid.org/0000-0001-8873-2545"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Hock","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111784445","display_name":"Jude E. Onyia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. E. Onyia","raw_affiliation_strings":["Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Division (R.R.M., J.P.S., R.F.S., L.V.H., G.B., K.T., J.M.H., J.E.O.), Lilly Research Labs, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111784445"],"corresponding_institution_ids":["https://openalex.org/I168537998"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.5879,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.90234304,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"141","issue":"1","first_page":"28","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgs2","display_name":"RGS2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/parathyroid-hormone-signaling","display_name":"parathyroid hormone signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-desensitization","display_name":"G protein-coupled receptor desensitization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/regulators-of-g-protein-signaling","display_name":"regulator of G protein signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.6129999756813049},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.593999981880188},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pth-related-protein","display_name":"PTH-related protein","score":0.800000011920929},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.421999990940094},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/parathyroid-hormone-analogues","display_name":"parathyroid hormone analog","score":0.5239999890327454},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.9800000190734863},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.4490000009536743},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.8009999990463257},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7749999761581421},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C4963665","wikidata":"https://www.wikidata.org/wiki/Q18031115","display_name":"RGS2","level":5,"score":0.9044052362442017},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.7729083299636841},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.7091457843780518},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6360979080200195},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5942164659500122},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5741075277328491},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5646825432777405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5545644760131836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5533860325813293},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5291828513145447},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.41771864891052246},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4105684161186218},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.40982016921043396},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3932066261768341},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37341850996017456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.217673659324646},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1598464846611023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1330828070640564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10834851861000061},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.09299194812774658},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.09101173281669617}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo.141.1.7229","doi":"https://doi.org/10.1210/endo.141.1.7229","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.141.1.7229","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.141.1.28","doi":"https://doi.org/10.1210/en.141.1.28","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.141.1.28","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:10614620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10614620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W4594923","https://openalex.org/W147240352","https://openalex.org/W1546972902","https://openalex.org/W1577776424","https://openalex.org/W1965048273","https://openalex.org/W1965963242","https://openalex.org/W1968093456","https://openalex.org/W1968950287","https://openalex.org/W1970820951","https://openalex.org/W1973852009","https://openalex.org/W1976547902","https://openalex.org/W1976820979","https://openalex.org/W1977493444","https://openalex.org/W1978368163","https://openalex.org/W1980479111","https://openalex.org/W1989347792","https://openalex.org/W1989817592","https://openalex.org/W1991662199","https://openalex.org/W1992006274","https://openalex.org/W1993485378","https://openalex.org/W1996293071","https://openalex.org/W1996916123","https://openalex.org/W1998056221","https://openalex.org/W2016418603","https://openalex.org/W2017277478","https://openalex.org/W2034762105","https://openalex.org/W2036207772","https://openalex.org/W2037593790","https://openalex.org/W2038312257","https://openalex.org/W2038370776","https://openalex.org/W2046102646","https://openalex.org/W2050307742","https://openalex.org/W2053217010","https://openalex.org/W2054004023","https://openalex.org/W2058017035","https://openalex.org/W2062766739","https://openalex.org/W2064674876","https://openalex.org/W2066109743","https://openalex.org/W2067855539","https://openalex.org/W2074508702","https://openalex.org/W2079239816","https://openalex.org/W2081426683","https://openalex.org/W2083713682","https://openalex.org/W2085731693","https://openalex.org/W2092203876","https://openalex.org/W2093224917","https://openalex.org/W2093595636","https://openalex.org/W2101512328","https://openalex.org/W2105420363","https://openalex.org/W2110458673","https://openalex.org/W2115588325","https://openalex.org/W2115800876","https://openalex.org/W2131558518","https://openalex.org/W2136972830","https://openalex.org/W2144459502","https://openalex.org/W2146386420","https://openalex.org/W2150947139","https://openalex.org/W2153705788","https://openalex.org/W2164413226","https://openalex.org/W2246359038","https://openalex.org/W2281400857","https://openalex.org/W2401503019","https://openalex.org/W3028351051","https://openalex.org/W4231134694"],"related_works":["https://openalex.org/W2039171759","https://openalex.org/W2128713588","https://openalex.org/W2111368094","https://openalex.org/W2076311461","https://openalex.org/W2044043080","https://openalex.org/W2133491837","https://openalex.org/W7095691287","https://openalex.org/W2013452232","https://openalex.org/W7096692654","https://openalex.org/W2013242641"],"abstract_inverted_index":{"The":[0],"initial":[1],"steps":[2],"involved":[3],"in":[4,63,86,114,184,198,262,277,295,300,325,343],"mediating":[5],"the":[6,22,31,80,90,168,282,285,303,329,336,349],"transduction":[7],"of":[8,24,48,55,65,79,107,119,170,302,348],"PTH":[9,87,109,182,217,235,288,324,353],"signal":[10],"via":[11,328],"its":[12],"G":[13,56,67],"protein-coupled":[14,68],"receptors":[15],"are":[16,40,99],"well":[17,42,196],"understood":[18],"and":[19,26,33,128,141,148,177,189,208,227,238,259,272,284,318,320],"occur":[20],"through":[21],"activation":[23],"cAMP":[25,210,223,244,330],"phospholipase":[27],"C":[28],"pathways.":[29],"However,":[30],"cellular":[32],"molecular":[34],"mechanisms":[35],"for":[36,96],"subsequent":[37],"receptor":[38],"desensitization":[39,64],"less":[41],"understood.":[43],"Recently,":[44],"a":[45,84,103,136],"new":[46],"family":[47],"GTPase":[49],"activating":[50],"proteins":[51,82],"known":[52,76],"as":[53,160,195,197],"regulators":[54],"protein":[57,140],"signaling":[58],"(RGS),":[59],"has":[60],"been":[61],"implicated":[62],"several":[66],"ligand-induced":[69],"processes.":[70],"At":[71],"present,":[72],"it":[73],"is":[74,175,256,312],"not":[75,242,299],"whether":[77],"any":[78,301],"RGS":[81,139],"play":[83],"role":[85],"signaling.":[88,354],"Using":[89],"differential":[91],"display":[92],"method,":[93],"we":[94,155],"screened":[95],"genes":[97],"that":[98,134,167,310,321,339],"selectively":[100],"expressed":[101,258],"after":[102],"single":[104],"s.c.":[105],"injection":[106],"human":[108,149,181],"(1-38)":[110,183],"(8":[111],"microg/100":[112],"g)":[113],"osteoblast-enriched":[115],"femoral":[116],"metaphyseal":[117,186],"spongiosa":[118],"young":[120],"male":[121],"rats":[122],"(3-4":[123],"weeks":[124],"old).":[125],"We":[126],"found":[127],"cloned":[129],"one":[130,347],"full-length":[131],"complementary":[132],"DNA":[133],"encodes":[135],"211-amino":[137],"acid":[138],"shares":[142],"97%":[143],"sequence":[144,153],"identity":[145],"with":[146,274],"mouse":[147],"RGS2.":[150,162],"Based":[151],"on":[152,249],"similarity,":[154],"have":[156],"designated":[157],"this":[158],"clone":[159],"rat":[161,296],"Northern":[163],"blot":[164],"analysis":[165],"confirmed":[166],"expression":[169,276,292,342],"RGS2":[171,213,231,255,290,311,341],"messenger":[172],"RNA":[173],"(mRNA)":[174],"rapidly":[176],"transiently":[178],"increased":[179,340],"by":[180,314,323],"both":[185],"(4-to":[187],"5-fold)":[188],"diaphyseal":[190],"(2-":[191,202],"to":[192,203],"3-fold)":[193],"bone,":[194],"cultured":[199],"osteoblast":[200],"cultures":[201],"37-fold).":[204],"In":[205,215,251],"vitro,":[206],"forskolin":[207],"dibutyryl":[209],"similarly":[211],"elevated":[212],"mRNA.":[214],"vivo,":[216],"analog":[218],"(1-31)":[219],"[which":[220],"stimulates":[221],"intracellular":[222],"accumulation,":[224],"PTHrP":[225,319],"(1-34),":[226],"prostaglandin":[228,316],"E2]":[229],"induced":[230,294],"mRNA":[232,291],"expression;":[233],"whereas":[234],"analogs":[236],"(3-34)":[237],"(7-34),":[239],"which":[240],"do":[241],"stimulate":[243],"production,":[245],"had":[246],"no":[247],"effect":[248],"expression.":[250],"tissue":[252],"distribution":[253],"analysis,":[254],"widely":[257],"was":[260,293],"detected":[261],"all":[263],"tissues":[264,305],"examined":[265],"(heart,":[266],"spleen,":[267],"liver,":[268],"skeletal":[269],"muscle,":[270],"kidney,":[271],"testis),":[273],"significant":[275],"two":[278],"nonclassical":[279],"PTH-sensitive":[280],"tissues:":[281],"brain,":[283],"heart.":[286],"After":[287],"injection,":[289],"bone":[297,326],"but":[298],"other":[304],"examined.":[306],"These":[307],"findings":[308],"demonstrate":[309],"regulated":[313],"PTH,":[315],"E2,":[317],"regulation":[322],"occurs":[327],"pathway.":[331],"Additionally,":[332],"these":[333],"results":[334],"suggest":[335],"exciting":[337],"possibility":[338],"osteoblasts":[344],"may":[345],"be":[346],"early":[350],"events":[351],"influencing":[352]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}