{"id":"https://openalex.org/W2058517675","doi":"https://doi.org/10.1055/s-0029-1225259","title":"Cardiovascular Disease Risk in Adult Women with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency","display_name":"Cardiovascular Disease Risk in Adult Women with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency","publication_year":2009,"publication_date":"2009-06-15","ids":{"openalex":"https://openalex.org/W2058517675","doi":"https://doi.org/10.1055/s-0029-1225259","mag":"2058517675","pmid":"https://pubmed.ncbi.nlm.nih.gov/19530065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4830727"},"language":"en","primary_location":{"id":"doi:10.1055/s-0029-1225259","doi":"https://doi.org/10.1055/s-0029-1225259","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1225259","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4830727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047678352","display_name":"Mimi S. Kim","orcid":"https://orcid.org/0000-0002-6266-3569","observed_orcids":["https://orcid.org/0000-0002-6266-3569"]},"institutions":[{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mimi Kim","raw_affiliation_strings":["Reproductive Biology and Medicine Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and The National Institutes of Health Clinical Center, Bethesda, MD 20892-1932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology and Medicine Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and The National Institutes of Health Clinical Center, Bethesda, MD 20892-1932, USA","institution_ids":["https://openalex.org/I4210144228","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021756024","display_name":"Deborah P. Merke","orcid":"https://orcid.org/0000-0002-3746-0460","observed_orcids":["https://orcid.org/0000-0002-3746-0460"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Merke","raw_affiliation_strings":["Reproductive Biology and Medicine Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and The National Institutes of Health Clinical Center, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology and Medicine Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, and The National Institutes of Health Clinical Center, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210144228","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3406,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.78616918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"04","first_page":"316","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/21-hydroxylase-deficiency","display_name":"21-hydroxylase deficiency","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9789999723434448},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.949999988079071},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9039999842643738},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9900000095367432},{"id":"https://openalex.org/keywords/subclinical-atherosclerosis","display_name":"subclinical atherosclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucocorticoid-therapy","display_name":"glucocorticoid therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/aldosterone-deficiency","display_name":"aldosterone deficiency","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.8421705961227417},{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.829596757888794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8206532597541809},{"id":"https://openalex.org/C2910605048","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Androgen Excess","level":5,"score":0.7862296104431152},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7183030843734741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6854950189590454},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6387872695922852},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5618119239807129},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.517639696598053},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5060645937919617},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5044056177139282},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.4778725206851959},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4266386032104492},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.42550987005233765},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22926077246665955},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.11274093389511108}],"mesh":[{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013255","descriptor_name":"Steroid 21-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1055/s-0029-1225259","doi":"https://doi.org/10.1055/s-0029-1225259","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1225259","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},{"id":"pmid:19530065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19530065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in reproductive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3799771","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4830727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4830727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4830727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Reprod Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3799771","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4830727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G550647324","display_name":null,"funder_award_id":"Z99CL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1964747486","https://openalex.org/W1971946657","https://openalex.org/W1992673626","https://openalex.org/W1999093110","https://openalex.org/W2011151629","https://openalex.org/W2011151996","https://openalex.org/W2018160024","https://openalex.org/W2019694761","https://openalex.org/W2025444530","https://openalex.org/W2030280115","https://openalex.org/W2030685863","https://openalex.org/W2038436669","https://openalex.org/W2043046125","https://openalex.org/W2045432341","https://openalex.org/W2046859247","https://openalex.org/W2049785493","https://openalex.org/W2050366634","https://openalex.org/W2056946782","https://openalex.org/W2057576181","https://openalex.org/W2059871080","https://openalex.org/W2063616586","https://openalex.org/W2066330033","https://openalex.org/W2068072549","https://openalex.org/W2078807483","https://openalex.org/W2090380777","https://openalex.org/W2095068198","https://openalex.org/W2099865362","https://openalex.org/W2100076759","https://openalex.org/W2100784798","https://openalex.org/W2123307512","https://openalex.org/W2124458165","https://openalex.org/W2125564127","https://openalex.org/W2128603969","https://openalex.org/W2131454803","https://openalex.org/W2143106726","https://openalex.org/W2144282526","https://openalex.org/W2144840283","https://openalex.org/W2151298139","https://openalex.org/W2154484638","https://openalex.org/W2157771966","https://openalex.org/W2165873915","https://openalex.org/W2167354898","https://openalex.org/W2169211586","https://openalex.org/W2171651945","https://openalex.org/W2328510686","https://openalex.org/W2343153954","https://openalex.org/W2345682597","https://openalex.org/W2413846380","https://openalex.org/W2916596946","https://openalex.org/W3172478362","https://openalex.org/W4210400066"],"related_works":["https://openalex.org/W2124458165","https://openalex.org/W2938426775","https://openalex.org/W2145309021","https://openalex.org/W4388223752","https://openalex.org/W2131502301","https://openalex.org/W2195076252","https://openalex.org/W1666173370","https://openalex.org/W1890257176","https://openalex.org/W3135669614","https://openalex.org/W3190075181"],"abstract_inverted_index":{"Congenital":[0],"adrenal":[1],"hyperplasia":[2],"(CAH)":[3],"due":[4],"to":[5,61,82,107,116],"21-hydroxylase":[6],"deficiency":[7],"is":[8,123],"a":[9,73],"common":[10],"autosomal":[11],"recessive":[12],"disorder":[13],"characterized":[14],"by":[15],"impaired":[16],"cortisol":[17],"biosynthesis,":[18],"with":[19,28,38,87,98,102,121],"or":[20],"without":[21],"aldosterone":[22],"deficiency,":[23],"and":[24,53,129,136],"androgen":[25],"excess.":[26],"Patients":[27,37],"the":[29,95,114],"classic":[30],"(severe)":[31],"form":[32],"also":[33,78],"have":[34,40],"epinephrine":[35],"deficiency.":[36],"CAH":[39,122],"an":[41,63],"increased":[42,84],"prevalence":[43],"of":[44,75,113],"risk":[45,65],"factors":[46],"for":[47,67],"cardiovascular":[48,68,108,117],"disease":[49,109,118],"including":[50],"obesity,":[51,132],"hypertension,":[52,135],"insulin":[54,133],"resistance.":[55],"Androgen":[56],"excess":[57],"in":[58,85,94,100,119],"women":[59,120],"appears":[60],"be":[62,83],"additional":[64],"factor":[66],"disease.":[69],"Carotid":[70],"intima-media":[71],"thickness,":[72],"measure":[74],"subclinical":[76],"atherosclerosis,":[77],"has":[79],"been":[80],"found":[81],"adults":[86],"CAH.":[88],"The":[89],"multiple":[90],"hormonal":[91],"imbalances":[92],"present":[93],"adult":[96],"woman":[97],"CAH,":[99],"combination":[101],"chronic":[103],"glucocorticoid":[104],"therapy,":[105],"contribute":[106],"risk.":[110],"Further":[111],"investigation":[112],"predisposition":[115],"warranted.":[124],"Longitudinal":[125],"studies":[126],"are":[127],"needed,":[128],"interventions":[130],"targeting":[131],"resistance,":[134],"hyperandrogenism":[137],"may":[138],"offer":[139],"improved":[140],"outcome.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
