{"id":"https://openalex.org/W2058504486","doi":"https://doi.org/10.1002/ana.410200412","title":"Cerebral metabolic effects of neonatal seizures measured with in vivo 31P NMR spectroscopy","display_name":"Cerebral metabolic effects of neonatal seizures measured with in vivo 31P NMR spectroscopy","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W2058504486","doi":"https://doi.org/10.1002/ana.410200412","mag":"2058504486","pmid":"https://pubmed.ncbi.nlm.nih.gov/3789667"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410200412","doi":"https://doi.org/10.1002/ana.410200412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410200412","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047879318","display_name":"Donald P. Younkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald P. Younkin","raw_affiliation_strings":["Departments of Neurology, University of Pennsylvania School of Medicine","Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104","Division of Neurology, Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Neurology, Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009123179","display_name":"Maria Delivoria\u2010Papadopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Delivoria\u2010Papadopoulos","raw_affiliation_strings":["Departments of Pediatrics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Maris","raw_affiliation_strings":["Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070478519","display_name":"Eileen Donlon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Donlon","raw_affiliation_strings":["Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075081789","display_name":"Robert Ryan Clancy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Clancy","raw_affiliation_strings":["Departments of Neurology, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112728827","display_name":"Britton Chance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britton Chance","raw_affiliation_strings":["Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Biophysics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047879318"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":7.8122,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.97790138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"513","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-seizures","display_name":"neonatal seizures","score":1.0},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.7689999938011169},{"id":"https://openalex.org/keywords/high-energy-phosphates","display_name":"high-energy phosphates","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phosphocreatine-to-inorganic-phosphate-ratio","display_name":"phosphocreatine to inorganic phosphate ratio","score":0.9440000057220459},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.6830000281333923},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.8149999976158142},{"id":"https://openalex.org/keywords/focal-seizures","display_name":"focal seizures","score":0.5429999828338623},{"id":"https://openalex.org/keywords/generalized-seizures","display_name":"generalized seizures","score":0.9760000109672546},{"id":"https://openalex.org/keywords/neurological-sequelae","display_name":"neurological sequelae","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cerebral-injury","display_name":"cerebral injury","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.9462084770202637},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5949999094009399},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.5624168515205383},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5438689589500427},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5180602073669434},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.44591429829597473},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.44155991077423096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42986708879470825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4263027012348175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42210423946380615},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.42114096879959106},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3597434163093567},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.2731413245201111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1902124583721161},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.184920996427536},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07313039898872375},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410200412","doi":"https://doi.org/10.1002/ana.410200412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410200412","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:3789667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3789667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2558010094","display_name":"REGIONAL CEREBRAL BLOOD FLOW IN HIGH RISK HUMAN NEWBORNS","funder_award_id":"K07NS000774","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5672160641","display_name":null,"funder_award_id":"HD/HL 18540","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1506939305","https://openalex.org/W1983046049","https://openalex.org/W1984216384","https://openalex.org/W1984376093","https://openalex.org/W1986638513","https://openalex.org/W1987598796","https://openalex.org/W1994782117","https://openalex.org/W1996718874","https://openalex.org/W1998077549","https://openalex.org/W2004857992","https://openalex.org/W2013885616","https://openalex.org/W2028671462","https://openalex.org/W2030769754","https://openalex.org/W2044239486","https://openalex.org/W2058728980","https://openalex.org/W2059569188","https://openalex.org/W2061496400","https://openalex.org/W2069463805","https://openalex.org/W2075008436","https://openalex.org/W2086279424","https://openalex.org/W2089257320","https://openalex.org/W2094780153","https://openalex.org/W2098877347","https://openalex.org/W2112457470","https://openalex.org/W2133586066","https://openalex.org/W2146586334","https://openalex.org/W2158516688","https://openalex.org/W2159170186","https://openalex.org/W2320355877","https://openalex.org/W2327335106","https://openalex.org/W4247854905"],"related_works":["https://openalex.org/W2045276402","https://openalex.org/W1982126656","https://openalex.org/W2052012249","https://openalex.org/W2411145435","https://openalex.org/W2052563473","https://openalex.org/W2085877499","https://openalex.org/W1969175961","https://openalex.org/W1994257795","https://openalex.org/W2030769754","https://openalex.org/W4385547321"],"abstract_inverted_index":{"In":[0],"vivo":[1],"phosphorus":[2],"31":[3],"nuclear":[4],"magnetic":[5],"resonance":[6],"(31P":[7],"NMR)":[8],"spectroscopy":[9],"was":[10],"used":[11],"to":[12,40,67,100],"evaluate":[13],"changes":[14],"in":[15,20,37,50,94],"cerebral":[16,106,150,154],"high-energy":[17],"phosphate":[18,42],"compounds":[19],"8":[21],"infants":[22],"with":[23,82],"seizures.":[24,123],"During":[25],"the":[26,38,51,95],"study":[27],"4":[28],"babies":[29,125],"had":[30,61,126],"seizures":[31,46,55,78,134,145],"that":[32,105,114,143],"caused":[33,47,56],"a":[34],"50%":[35],"decrease":[36],"phosphocreatine":[39],"inorganic":[41],"(PCr/Pi)":[43],"ratio.":[44],"Focal":[45],"lateralized":[48],"decreases":[49,109],"PCr/Pi":[52,63,96,127],"ratio;":[53],"generalized":[54],"bilateral":[57],"decreases.":[58],"Postictal":[59],"spectra":[60,73],"increased":[62],"ratios,":[64],"presumably":[65],"due":[66],"postictal":[68],"inhibition.":[69],"Interictal":[70],"31P":[71],"NMR":[72,87],"were":[74,79],"normal.":[75],"One":[76],"patient's":[77],"successfully":[80],"treated":[81],"intravenously":[83],"administered":[84],"phenobarbital":[85],"during":[86,121,133],"data":[88],"acquisition,":[89],"causing":[90],"an":[91],"immediate":[92],"increase":[93],"ratio":[97],"from":[98],"0.7":[99],"1.2.":[101],"These":[102],"studies":[103],"indicate":[104],"PCr":[107],"concentration":[108],"by":[110,118,152],"approximately":[111,119],"33%":[112],"and":[113,135],"oxidative":[115],"metabolism":[116],"increases":[117],"45%":[120],"neonatal":[122,144],"Five":[124],"ratios":[128],"of":[129],"less":[130],"than":[131],"0.8":[132],"subsequently":[136],"developed":[137],"long-term":[138],"neurological":[139],"sequelae,":[140],"which":[141],"suggests":[142],"may":[146],"cause":[147],"or":[148],"exacerbate":[149],"injury":[151],"increasing":[153],"metabolic":[155],"demands":[156],"above":[157],"energy":[158],"supply.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
