{"id":"https://openalex.org/W205849754","doi":"https://doi.org/10.1023/a:1015147729564","title":"A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers","display_name":"A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W205849754","doi":"https://doi.org/10.1023/a:1015147729564","mag":"205849754","pmid":"https://pubmed.ncbi.nlm.nih.gov/12033383"},"language":"en","primary_location":{"id":"doi:10.1023/a:1015147729564","doi":"https://doi.org/10.1023/a:1015147729564","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015147729564","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013118213","display_name":"Xiaolin Charlie Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin Charlie Tang","raw_affiliation_strings":["School of Pharmacy, University of Connecticut, Storrs 06296-2092, USA","School of Pharmacy, U-2092, University of Connecticut, Storrs,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Connecticut, Storrs 06296-2092, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"School of Pharmacy, U-2092, University of Connecticut, Storrs,","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064626648","display_name":"Michael Jon Pikal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Pikal","raw_affiliation_strings":["School of Pharmacy, U-2092, University of Connecticut, 372 Fairfield Road, Storrs, Connecticutt, 06296-2092","School of Pharmacy, U-2092, University of Connecticut, Storrs,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, U-2092, University of Connecticut, 372 Fairfield Road, Storrs, Connecticutt, 06296-2092","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"School of Pharmacy, U-2092, University of Connecticut, Storrs,","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090835640","display_name":"Lynne S. Taylor","orcid":"https://orcid.org/0000-0002-4568-6021","observed_orcids":["https://orcid.org/0000-0002-4568-6021"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Lynne S. Taylor","raw_affiliation_strings":["Solid State Analysis, Pharmaceutical and Analytical R&D, AstraZeneca R&D M\u00f6lndal, S-431 83, M\u00f6lndal, Sweden","Solid State Analysis, Pharmaceutical and Analytical R&D, AstraZeneca R&D Molndal, S-431 83 Molndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Solid State Analysis, Pharmaceutical and Analytical R&D, AstraZeneca R&D M\u00f6lndal, S-431 83, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]},{"raw_affiliation_string":"Solid State Analysis, Pharmaceutical and Analytical R&D, AstraZeneca R&D Molndal, S-431 83 Molndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090835640"],"corresponding_institution_ids":["https://openalex.org/I4210143795"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.9821,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.82654978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"19","issue":"4","first_page":"477","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.902999997138977},{"id":"https://openalex.org/keywords/amorphous-drug","display_name":"amorphous drug","score":0.7059999704360962},{"id":"https://openalex.org/keywords/n-h-stretching-vibrations","display_name":"N-H stretching vibrations","score":0.6000000238418579},{"id":"https://openalex.org/keywords/ft-raman-spectroscopy","display_name":"FT-Raman spectroscopy","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.8141235113143921},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7528451681137085},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5592865347862244},{"id":"https://openalex.org/C2779892579","wikidata":"https://www.wikidata.org/wiki/Q912138","display_name":"Acceptor","level":2,"score":0.5376990437507629},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.5359341502189636},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.45321011543273926},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4433749318122864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42133858799934387},{"id":"https://openalex.org/C153642686","wikidata":"https://www.wikidata.org/wiki/Q70906","display_name":"Infrared spectroscopy","level":2,"score":0.4141010642051697},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.4139062464237213},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40904074907302856},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2513728141784668},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18497344851493835},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D004095","descriptor_name":"Dihydropyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1015147729564","doi":"https://doi.org/10.1023/a:1015147729564","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015147729564","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:12033383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12033383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.550000011920929,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W179754899","https://openalex.org/W625272620","https://openalex.org/W1276324155","https://openalex.org/W1516297516","https://openalex.org/W1543696264","https://openalex.org/W1964507612","https://openalex.org/W1968867202","https://openalex.org/W1972982314","https://openalex.org/W1986036102","https://openalex.org/W1991553520","https://openalex.org/W1992029252","https://openalex.org/W1997294622","https://openalex.org/W1998920258","https://openalex.org/W2025263195","https://openalex.org/W2035530409","https://openalex.org/W2035715009","https://openalex.org/W2037617202","https://openalex.org/W2056444306","https://openalex.org/W2070625559","https://openalex.org/W2077578726","https://openalex.org/W2082152087","https://openalex.org/W2090910490","https://openalex.org/W2091339325","https://openalex.org/W2316822864","https://openalex.org/W6619910850"],"related_works":["https://openalex.org/W1528404741","https://openalex.org/W2010641206","https://openalex.org/W4401088088","https://openalex.org/W1993841237","https://openalex.org/W4416275399","https://openalex.org/W2327648393","https://openalex.org/W2042460760","https://openalex.org/W4376109421","https://openalex.org/W2005403437","https://openalex.org/W2123104340"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}