{"id":"https://openalex.org/W2058490656","doi":"https://doi.org/10.1371/journal.pone.0117937","title":"Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway","display_name":"Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway","publication_year":2015,"publication_date":"2015-03-03","ids":{"openalex":"https://openalex.org/W2058490656","doi":"https://doi.org/10.1371/journal.pone.0117937","mag":"2058490656","pmid":"https://pubmed.ncbi.nlm.nih.gov/25734240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348516"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0117937","doi":"https://doi.org/10.1371/journal.pone.0117937","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117937","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117937&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117937&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kenji Takemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Takemoto","raw_affiliation_strings":["Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086302856","display_name":"Seiichiro Ishihara","orcid":"https://orcid.org/0009-0000-6148-449X","observed_orcids":["https://orcid.org/0009-0000-6148-449X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichiro Ishihara","raw_affiliation_strings":["Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan; Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan; Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053489495","display_name":"Takeomi Mizutani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeomi Mizutani","raw_affiliation_strings":["Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111598368","display_name":"Kazushige Kawabata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazushige Kawabata","raw_affiliation_strings":["Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077206064","display_name":"Hisashi Haga","orcid":"https://orcid.org/0000-0001-9464-6723","observed_orcids":["https://orcid.org/0000-0001-9464-6723"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hisashi Haga","raw_affiliation_strings":["Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan; Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan; Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Transdisciplinary Life Science Course, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077206064"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.8114,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.65116543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"e0117937","last_page":"e0117937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/compressive-stress","display_name":"compressive stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myosin-regulatory-light-chain","display_name":"myosin regulatory light chain","score":0.9409999847412109},{"id":"https://openalex.org/keywords/myosin-phosphatase","display_name":"myosin phosphatase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/extracellular-matrix-deformation","display_name":"extracellular matrix deformation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cell-stretching","display_name":"cell stretching","score":0.5220000147819519},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.9776611328125},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.7854932546615601},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7707628011703491},{"id":"https://openalex.org/C2779938346","wikidata":"https://www.wikidata.org/wiki/Q1956701","display_name":"Myosin-light-chain phosphatase","level":4,"score":0.6496710777282715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6012099385261536},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5293377637863159},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.527804970741272},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.5040887594223022},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4183889627456665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37898552417755127},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37082839012145996},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2983512282371521}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019245","descriptor_name":"Compressive Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043263","descriptor_name":"Myosin-Light-Chain Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0117937","doi":"https://doi.org/10.1371/journal.pone.0117937","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117937","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117937&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3317912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348516","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4348516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348516","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25734240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25734240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007176355","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/59277","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/59277/PO10-3 e0117937.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE","raw_type":"journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.795.7861","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.795.7861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c8/7f/pone.0117937.PMC4348516.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2e597e59a61e45fb8d9f15688fc7769a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2e597e59a61e45fb8d9f15688fc7769a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 3, p e0117937 (2015)","raw_type":"article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/59277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/59277","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1321828","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Compressive_Stress_Induces_Dephosphorylation_of_the_Myosin_Regulatory_Light_Chain_via_RhoA_Phosphorylation_by_the_Adenylyl_Cyclase_Protein_Kinase_A_Signaling_Pathway_/1321828","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0117937","doi":"https://doi.org/10.1371/journal.pone.0117937","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117937","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117937&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1755468937","display_name":"Aimed for the elucidation of mechanism of collective multi-cellular migration during 3D morphogenesis","funder_award_id":"25287106","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4152582920","display_name":null,"funder_award_id":"26430104","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G45232439","display_name":null,"funder_award_id":"26106704","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4578112616","display_name":null,"funder_award_id":"25287106","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G570423481","display_name":"Stiff Substrates Enhances ATF5-Signaling-Mediated Invasive Ability in Cancer Cells","funder_award_id":"26430104","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8558117747","display_name":"Tension-induced conformational changes of actin filaments and their influence on actin binding and intracellular localization of myosin.","funder_award_id":"24370069","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058490656.pdf","grobid_xml":"https://content.openalex.org/works/W2058490656.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W136783517","https://openalex.org/W195235204","https://openalex.org/W1236053900","https://openalex.org/W1518499796","https://openalex.org/W1532410395","https://openalex.org/W1568617917","https://openalex.org/W1600241919","https://openalex.org/W1971431976","https://openalex.org/W1977966187","https://openalex.org/W1981675859","https://openalex.org/W1985502400","https://openalex.org/W1991055833","https://openalex.org/W1999720993","https://openalex.org/W2001587874","https://openalex.org/W2003603726","https://openalex.org/W2010804860","https://openalex.org/W2015467981","https://openalex.org/W2023072510","https://openalex.org/W2023392069","https://openalex.org/W2028018976","https://openalex.org/W2037202171","https://openalex.org/W2037425060","https://openalex.org/W2040180365","https://openalex.org/W2043442465","https://openalex.org/W2043556663","https://openalex.org/W2052750950","https://openalex.org/W2055601386","https://openalex.org/W2057139885","https://openalex.org/W2058096164","https://openalex.org/W2063316140","https://openalex.org/W2064071063","https://openalex.org/W2068984345","https://openalex.org/W2069597305","https://openalex.org/W2070439333","https://openalex.org/W2075482835","https://openalex.org/W2081232698","https://openalex.org/W2089194388","https://openalex.org/W2089276045","https://openalex.org/W2091031177","https://openalex.org/W2095574876","https://openalex.org/W2096180149","https://openalex.org/W2105749810","https://openalex.org/W2117403796","https://openalex.org/W2135096442","https://openalex.org/W2137580023","https://openalex.org/W2146337514","https://openalex.org/W2147624737","https://openalex.org/W2147822047","https://openalex.org/W2150193964","https://openalex.org/W2153831583","https://openalex.org/W2156193902","https://openalex.org/W2156569821","https://openalex.org/W2161161532","https://openalex.org/W2164525353","https://openalex.org/W2166769784","https://openalex.org/W2166917408","https://openalex.org/W2167646491","https://openalex.org/W2170355588"],"related_works":["https://openalex.org/W7100237371","https://openalex.org/W1588818212","https://openalex.org/W1148873144","https://openalex.org/W2095574876","https://openalex.org/W6920993113","https://openalex.org/W1997176820","https://openalex.org/W2288905266","https://openalex.org/W1732270201","https://openalex.org/W152404281","https://openalex.org/W2790676839"],"abstract_inverted_index":{"Mechanical":[0],"stress":[1,56,75],"that":[2,185,200,229],"arises":[3],"due":[4,179],"to":[5,20,71,96,111,160,180,190],"deformation":[6],"of":[7,31,54,88,118,125,150,166,170,182,188,196,206,214,222],"the":[8,32,39,52,97,123,194],"extracellular":[9],"matrix":[10],"(ECM)":[11],"either":[12],"stretches":[13],"or":[14],"compresses":[15],"cells.":[16,249],"The":[17,64,163],"cellular":[18,48,58],"response":[19,98,159],"stretching":[21,28,72,100,211,246],"has":[22],"been":[23],"actively":[24],"studied.":[25],"For":[26],"example,":[27],"induces":[29],"phosphorylation":[30,86,181,213,220,231],"myosin":[33,119,126,133],"regulatory":[34],"light":[35],"chain":[36],"(MRLC)":[37],"via":[38,122],"RhoA/RhoA-associated":[40],"protein":[41,197],"kinase":[42,198],"(ROCK)":[43],"pathway,":[44],"resulting":[45],"in":[46,99,158],"increased":[47,157],"tension.":[49],"In":[50],"contrast,":[51],"effects":[53],"compressive":[55,74,93,112,144,161,240],"on":[57],"functions":[59],"are":[60,76,174],"not":[61,77,218],"fully":[62],"resolved.":[63],"mechanisms":[65],"for":[66,236,243],"sensing":[67],"and":[68,73,168,242,247],"differentially":[69],"responding":[70],"known.":[78],"To":[79],"address":[80],"these":[81],"questions,":[82],"we":[83],"investigated":[84],"whether":[85],"levels":[87,221],"MRLC":[89,102,208,237],"were":[90,109],"affected":[91],"by":[92,142,239],"stress.":[94,113,162],"Contrary":[95],"cells,":[101],"was":[103,178],"dephosphorylated":[104],"5":[105],"min":[106],"after":[107],"cells":[108],"subjected":[110],"Compressive":[114],"loading":[115,145],"induced":[116,148,204,212],"activation":[117,165],"phosphatase":[120,127,134],"mediated":[121],"dephosphorylation":[124,238],"targeting":[128,135],"subunit":[129,136],"1":[130,137],"(Thr853).":[131],"Because":[132],"(Thr853)":[138],"is":[139,232],"phosphorylated":[140],"only":[141],"ROCK,":[143],"may":[146],"have":[147],"inactivation":[149,169],"ROCK.":[151,191],"However,":[152],"GTP-bound":[153],"RhoA":[154,167,183,189,202,223,230],"(active":[155],"form)":[156],"compression-induced":[164],"its":[171],"effector":[172],"ROCK":[173],"contradictory.":[175],"This":[176],"inconsistency":[177],"(Ser188)":[184,203],"reduced":[186],"affinity":[187],"Treatment":[192],"with":[193],"inhibitor":[195],"A":[199],"phosphorylates":[201],"suppression":[205],"compression-stimulated":[207],"dephosphorylation.":[209],"Incidentally,":[210],"MRLC,":[215],"but":[216],"did":[217],"affect":[219],"(Ser188).":[224],"Together,":[225],"our":[226],"results":[227],"suggest":[228],"an":[233],"important":[234],"process":[235],"loading,":[241],"distinguishing":[244],"between":[245],"compressing":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}