{"id":"https://openalex.org/W2058418451","doi":"https://doi.org/10.1172/jci115811","title":"Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.","display_name":"Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2058418451","doi":"https://doi.org/10.1172/jci115811","mag":"2058418451","pmid":"https://pubmed.ncbi.nlm.nih.gov/1376331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/295910"},"language":"en","primary_location":{"id":"doi:10.1172/jci115811","doi":"https://doi.org/10.1172/jci115811","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115811","pdf_url":"http://www.jci.org/articles/view/115811/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/115811/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014010562","display_name":"B. Felding-Habermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Felding-Habermann","raw_affiliation_strings":["Department of Immunology, Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833499","display_name":"Barbara M. Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B M Mueller","raw_affiliation_strings":["Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087339042","display_name":"Cynthia A. Romerdahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Romerdahl","raw_affiliation_strings":["Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Cheresh","raw_affiliation_strings":["Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofImmunology, The Scripps Research Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":6.798,"has_fulltext":true,"cited_by_count":371,"citation_normalized_percentile":{"value":0.97289757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"89","issue":"6","first_page":"2018","last_page":"2022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.8870000243186951},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tumor-growth-in-nude-mice","display_name":"tumor growth in nude mice","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.8637698888778687},{"id":"https://openalex.org/C2777141677","wikidata":"https://www.wikidata.org/wiki/Q50254584","display_name":"Alpha-v beta-3","level":5,"score":0.8012964129447937},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.747687041759491},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7327392101287842},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5436210036277771},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.502772331237793},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4419761896133423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42904385924339294},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4167952537536621},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3782484829425812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35921311378479004},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34167128801345825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2864132523536682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16905111074447632},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci115811","doi":"https://doi.org/10.1172/jci115811","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115811","pdf_url":"http://www.jci.org/articles/view/115811/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:295910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/295910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:1376331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1376331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci115811","doi":"https://doi.org/10.1172/jci115811","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115811","pdf_url":"http://www.jci.org/articles/view/115811/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G243309107","display_name":"Integrin alpha v beta 3 promotes resistance to EGF receptor inhibitors","funder_award_id":"R01CA045726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058418451.pdf","grobid_xml":"https://content.openalex.org/works/W2058418451.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1524285426","https://openalex.org/W1529646916","https://openalex.org/W1577857859","https://openalex.org/W1583080588","https://openalex.org/W1594121967","https://openalex.org/W1634520049","https://openalex.org/W1971794257","https://openalex.org/W1976432358","https://openalex.org/W1978160288","https://openalex.org/W1987568997","https://openalex.org/W1989247542","https://openalex.org/W1991011809","https://openalex.org/W1992560092","https://openalex.org/W2011497948","https://openalex.org/W2013381560","https://openalex.org/W2025260035","https://openalex.org/W2041002260","https://openalex.org/W2057876887","https://openalex.org/W2069294982","https://openalex.org/W2102193002","https://openalex.org/W2113554746","https://openalex.org/W2156260681","https://openalex.org/W2338174965"],"related_works":["https://openalex.org/W2169424249","https://openalex.org/W2354972079","https://openalex.org/W1514170807","https://openalex.org/W2130180403","https://openalex.org/W6997458478","https://openalex.org/W2085121809","https://openalex.org/W2115636784","https://openalex.org/W2075885982","https://openalex.org/W1533067566","https://openalex.org/W2039496775"],"abstract_inverted_index":{"Human":[0],"melanoma":[1,15,82,106,223],"originates":[2],"in":[3,76,146,172,186,218,224],"the":[4,21,34,77,91,98,135,187,211,219],"skin":[5],"and":[6,61,118,169,199,210],"can":[7],"lead":[8],"to":[9,89,121,137,139],"wide-spread":[10],"metastatic":[11],"disease.":[12],"Analysis":[13],"of":[14,33,80,93,100,190,221],"biopsy":[16],"material":[17],"has":[18],"shown":[19],"that":[20,112],"vitronectin":[22,140],"receptor,":[23],"integrin":[24,123,167,191,205],"alpha":[25,94,114,124,182,192,206],"v":[26,95,115,125,193,207],"beta":[27,126,165,194],"3,":[28],"is":[29],"a":[30,70,143,180],"specific":[31],"marker":[32],"most":[35],"malignant":[36,78],"cells,":[37,107,157],"i.e.,":[38],"vertically":[39],"invasive":[40],"primary":[41],"lesions":[42],"or":[43],"distant":[44],"metastases":[45],"(Albelda,":[46],"S.":[47,49],"M.,":[48],"A.":[50,63],"Mette,":[51],"D.":[52],"E.":[53],"Elder,":[54],"R.":[55],"Stewart,":[56],"L.":[57],"Damjanovich,":[58],"M.":[59],"Herlyn,":[60],"C.":[62],"Buck.":[64],"1990.":[65],"Cancer":[66],"Res.":[67],"50:6757-6764),":[68],"suggesting":[69],"role":[71,92],"for":[72],"this":[73],"adhesion":[74],"receptor":[75],"growth":[79,170],"human":[81,101,105,222],"tumors.":[83],"A":[84],"cell":[85,161],"model":[86],"was":[87],"established":[88],"analyze":[90],"integrins":[96],"on":[97,196],"tumorigenicity":[99,147],"melanoma.":[102],"From":[103],"M21":[104,156],"stable":[108],"variants":[109],"were":[110,176],"selected":[111],"lack":[113],"gene":[116,208],"expression":[117,168,189,209],"thus":[119],"fail":[120],"express":[122],"3":[127,195],"(M21-L":[128],"cells).":[129],"These":[130],"cells":[131,175,198],"not":[132],"only":[133],"lost":[134],"ability":[136],"attach":[138],"but":[141],"showed":[142,163],"dramatic":[144],"reduction":[145],"when":[148],"transplanted":[149],"into":[150],"athymic":[151],"nude":[152],"mice,":[153],"compared":[154],"with":[155,179],"even":[158],"though":[159],"both":[160],"types":[162],"identical":[164],"1":[166],"properties":[171],"vitro.":[173],"M21-L":[174],"stably":[177],"transfected":[178],"cDNA-encoding":[181],"v.":[183],"This":[184],"resulted":[185],"functional":[188],"these":[197],"completely":[200],"restored":[201],"their":[202],"tumorigenicity.":[203],"Thus,":[204],"resulting":[212],"adhesive":[213],"phenotype":[214],"are":[215],"directly":[216],"involved":[217],"proliferation":[220],"vivo.":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}