{"id":"https://openalex.org/W2058382002","doi":"https://doi.org/10.1134/s0006297912080032","title":"Serine proteases of small intestine mucosa \u2014 localization, functional properties, and physiological role","display_name":"Serine proteases of small intestine mucosa \u2014 localization, functional properties, and physiological role","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2058382002","doi":"https://doi.org/10.1134/s0006297912080032","mag":"2058382002","pmid":"https://pubmed.ncbi.nlm.nih.gov/22860904"},"language":"en","primary_location":{"id":"doi:10.1134/s0006297912080032","doi":"https://doi.org/10.1134/s0006297912080032","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297912080032","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038929213","display_name":"Tatyana S. Zamolodchikova","orcid":"https://orcid.org/0000-0003-3042-8123","observed_orcids":["https://orcid.org/0000-0003-3042-8123"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"T. S. Zamolodchikova","raw_affiliation_strings":["Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia. tatyanazam@yandex.ru","Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia. tatyanazam@yandex.ru","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]},{"raw_affiliation_string":"Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038929213"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"],"apc_list":null,"apc_paid":null,"fwci":0.0265,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.03354633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"77","issue":"8","first_page":"820","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":1.0},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/proteolytic-system","display_name":"proteolytic system","score":0.7020000219345093},{"id":"https://openalex.org/keywords/enzyme-localization","display_name":"enzyme localization","score":0.5789999961853027},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/intestinal-physiology","display_name":"intestinal physiology","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.7879999876022339},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8401066064834595},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6660196781158447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5890479683876038},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.512825071811676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43709596991539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37581655383110046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34442728757858276},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17268913984298706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1607179343700409},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.1135629415512085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10122019052505493}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1134/s0006297912080032","doi":"https://doi.org/10.1134/s0006297912080032","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297912080032","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},{"id":"pmid:22860904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22860904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W17585068","https://openalex.org/W28503687","https://openalex.org/W93701885","https://openalex.org/W151755804","https://openalex.org/W287635977","https://openalex.org/W1541130370","https://openalex.org/W1595443666","https://openalex.org/W1607367030","https://openalex.org/W1764686129","https://openalex.org/W1889671843","https://openalex.org/W1963689348","https://openalex.org/W1967561415","https://openalex.org/W1972468530","https://openalex.org/W1973337442","https://openalex.org/W1975317517","https://openalex.org/W1983233834","https://openalex.org/W1984895777","https://openalex.org/W1985469117","https://openalex.org/W1985908808","https://openalex.org/W1986079060","https://openalex.org/W1988003018","https://openalex.org/W1989844217","https://openalex.org/W1990083032","https://openalex.org/W1993212600","https://openalex.org/W1995985664","https://openalex.org/W2001418582","https://openalex.org/W2012730541","https://openalex.org/W2014028746","https://openalex.org/W2017154935","https://openalex.org/W2017906988","https://openalex.org/W2019436999","https://openalex.org/W2019473572","https://openalex.org/W2019965724","https://openalex.org/W2020179673","https://openalex.org/W2020745334","https://openalex.org/W2033514781","https://openalex.org/W2035656939","https://openalex.org/W2040156640","https://openalex.org/W2041305003","https://openalex.org/W2042037868","https://openalex.org/W2048105929","https://openalex.org/W2053373082","https://openalex.org/W2054267190","https://openalex.org/W2057377251","https://openalex.org/W2058030365","https://openalex.org/W2064979212","https://openalex.org/W2069508712","https://openalex.org/W2069849774","https://openalex.org/W2075502795","https://openalex.org/W2075503331","https://openalex.org/W2075733059","https://openalex.org/W2078251936","https://openalex.org/W2080781293","https://openalex.org/W2081334212","https://openalex.org/W2093218029","https://openalex.org/W2099979653","https://openalex.org/W2102762329","https://openalex.org/W2109513838","https://openalex.org/W2110337690","https://openalex.org/W2119542456","https://openalex.org/W2124210515","https://openalex.org/W2130629048","https://openalex.org/W2130901675","https://openalex.org/W2133183478","https://openalex.org/W2133896679","https://openalex.org/W2134935858","https://openalex.org/W2137081005","https://openalex.org/W2142906420","https://openalex.org/W2161162578","https://openalex.org/W2233848687","https://openalex.org/W2321266735","https://openalex.org/W2331364727","https://openalex.org/W2400105865","https://openalex.org/W2431666328","https://openalex.org/W6610316669"],"related_works":["https://openalex.org/W2049172646","https://openalex.org/W2479372486","https://openalex.org/W2403468365","https://openalex.org/W2424949517","https://openalex.org/W2336212486","https://openalex.org/W4297956708","https://openalex.org/W3154383277","https://openalex.org/W257391828","https://openalex.org/W1996970643","https://openalex.org/W1952055293"],"abstract_inverted_index":{"In":[0],"this":[1,21,67,103],"review":[2],"we":[3],"present":[4],"data":[5],"about":[6,48],"small":[7,95],"intestine":[8,96],"serine":[9,54],"proteases,":[10],"which":[11,112],"are":[12,45],"a":[13,59,87],"considerable":[14],"part":[15,23,80,106],"of":[16,24,30,42,53,81,93,102,107,116,126,130,138],"the":[17,25,69,73,82,91,94,99,108,139],"proteolytic":[18],"apparatus":[19],"in":[20,58,78,90,111,122],"major":[22],"gastrointestinal":[26],"tract.":[27],"Serine":[28,84],"proteases":[29,55,85],"intestinal":[31],"epitheliocytes,":[32],"their":[33],"structural-functional":[34],"features,":[35],"cellular":[36],"localization,":[37],"physiological":[38,65],"substrates,":[39],"and":[40,50,64,97,114,124,135],"mechanisms":[41,137],"activity":[43,129],"regulation":[44],"examined.":[46],"Information":[47],"biochemical":[49],"functional":[51,74],"properties":[52],"is":[56],"presented":[57],"common":[60],"context":[61],"with":[62],"morphological":[63],"data,":[66],"being":[68],"basis":[70],"for":[71],"understanding":[72],"processes":[75],"taking":[76],"place":[77],"upper":[79],"intestine.":[83,140],"play":[86],"key":[88],"role":[89],"physiology":[92],"provide":[98],"normal":[100],"functioning":[101],"organ":[104],"as":[105],"digestive":[109],"system":[110],"hydrolysis":[113],"suction":[115],"food":[117],"substances":[118],"occur.":[119],"They":[120],"participate":[121],"renewal":[123],"remodeling":[125],"tissues,":[127],"retractive":[128],"smooth":[131],"musculature,":[132],"hormonal":[133],"regulation,":[134],"defense":[136]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}