{"id":"https://openalex.org/W2058350238","doi":"https://doi.org/10.1159/000057009","title":"Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma","display_name":"Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2058350238","doi":"https://doi.org/10.1159/000057009","mag":"2058350238","pmid":"https://pubmed.ncbi.nlm.nih.gov/11978962"},"language":"en","primary_location":{"id":"doi:10.1159/000057009","doi":"https://doi.org/10.1159/000057009","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000057009","pdf_url":null,"source":{"id":"https://openalex.org/S4394735535","display_name":"Cytogenetic and Genome Research","issn_l":"1424-859X","issn":["1424-859X","1424-8581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetic and Genome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074405664","display_name":"Marice Mullarkey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. Mullarkey","raw_affiliation_strings":["National Centre for Medical Genetics, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland","Children's Research Centre, Departments of","National Centre for Medical Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Medical Genetics, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I3017411684"]},{"raw_affiliation_string":"Children's Research Centre, Departments of","institution_ids":[]},{"raw_affiliation_string":"National Centre for Medical Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074186677","display_name":"Conor J. Breen","orcid":"https://orcid.org/0000-0003-4737-7350","observed_orcids":["https://orcid.org/0000-0003-4737-7350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.J. Breen","raw_affiliation_strings":["National Centre for Medical Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Medical Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060095007","display_name":"Michael McDermott","orcid":"https://orcid.org/0000-0002-1015-0745","observed_orcids":["https://orcid.org/0000-0002-1015-0745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. McDermott","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088259709","display_name":"Anne O\u2019Meara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A. O\u2019Meara","raw_affiliation_strings":["Oncology, Our Lady\u2019s Hospital for Sick Children, Crumlin, Dublin (Ireland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Our Lady\u2019s Hospital for Sick Children, Crumlin, Dublin (Ireland)","institution_ids":["https://openalex.org/I3017411684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109866643","display_name":"Raymond L. Stallings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.L. Stallings","raw_affiliation_strings":["National Centre for Medical Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Medical Genetics,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4969,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72153607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"95","issue":"1-2","first_page":"9","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.4242999851703644,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.4242999851703644,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3319999873638153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chromosome-gains-and-losses","display_name":"chromosome gains and losses","score":0.6269999742507935},{"id":"https://openalex.org/keywords/chromosome-1q-gain","display_name":"chromosome 1q gain","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chromosome-17p-deletion","display_name":"chromosome 17p deletion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pediatric-liver-tumors","display_name":"pediatric liver tumors","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.9229922294616699},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7447935938835144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7409080266952515},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.574398934841156},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5566587448120117},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.529155969619751},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5181904435157776},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.43588465452194214},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.42945927381515503},{"id":"https://openalex.org/C109748351","wikidata":"https://www.wikidata.org/wiki/Q657319","display_name":"Chromosome 7 (human)","level":4,"score":0.42895135283470154},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3514825701713562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33491116762161255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2662278413772583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19066059589385986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15914031863212585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09653070569038391}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000057009","doi":"https://doi.org/10.1159/000057009","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000057009","pdf_url":null,"source":{"id":"https://openalex.org/S4394735535","display_name":"Cytogenetic and Genome Research","issn_l":"1424-859X","issn":["1424-859X","1424-8581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetic and Genome Research","raw_type":"journal-article"},{"id":"pmid:11978962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11978962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetics and cell genetics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W158083236","https://openalex.org/W1488090890","https://openalex.org/W1995361400","https://openalex.org/W2010254515","https://openalex.org/W2038579480","https://openalex.org/W2151530333"],"related_works":["https://openalex.org/W158083236","https://openalex.org/W2048180879","https://openalex.org/W2007751193","https://openalex.org/W1488090890","https://openalex.org/W3143700604","https://openalex.org/W2038579480","https://openalex.org/W2012164448","https://openalex.org/W1995361400","https://openalex.org/W2018478732","https://openalex.org/W4255972044"],"abstract_inverted_index":{"Comparative":[0],"genomic":[1],"hybridization":[2],"(CGH)":[3],"analysis":[4,59],"was":[5,27,169],"performed":[6],"on":[7],"both":[8,33],"a":[9,15,24,28,45],"pre-":[10,116],"and":[11,35,72,94,110,117,140,146,177,185,199],"post-chemotherapy":[12,42,99,118,154],"hepatoblastoma":[13],"from":[14,23],"24-month-old":[16],"female":[17],"patient.":[18],"The":[19,80,128,156],"diagnostic":[20,81,175],"sample":[21,82],"obtained":[22],"tru-cut":[25],"biopsy":[26],"mixed":[29],"epithelial-mesenchymal":[30],"tumor":[31,43,100],"with":[32,191,203],"fetal":[34],"embryonal":[36],"patterns":[37],"present.":[38],"In":[39,113],"contrast,":[40],"the":[41,70,98,115,132,143,153,165,174],"exhibited":[44],"prominent":[46],"anaplastic":[47],"large":[48],"cell":[49],"population":[50],"focally":[51],"reminiscent":[52],"of":[53,74,85,103,124,138,148,167,183,196],"pleomorphic":[54],"hepatocellular":[55],"carcinoma":[56],"(HCC).":[57],"CGH":[58],"indicated":[60],"that":[61,194],"there":[62],"were":[63],"similarities":[64],"as":[65,67],"well":[66],"differences":[68,130],"in":[69,77,142,152,162,171],"gains":[71,84,102],"losses":[73],"genetic":[75],"material":[76,151],"each":[78],"tumor.":[79,155],"had":[83,101],"chromosome":[86,125,149,197],"1q,":[87,104],"2,":[88,105],"2(q31q33),":[89],"7,":[90,106],"8q,":[91,107],"12(q15q22),":[92],"17q":[93,109],"20":[95,111,200],"material,":[96],"while":[97],"10,":[108],"material.":[112,127],"addition,":[114],"samples":[119,134],"may":[120],"have":[121,180],"incurred":[122],"loss":[123],"17p":[126],"main":[129],"between":[131],"two":[133],"involved":[135],"localized":[136,181],"gain":[137,147,182,195],"2(q31q33)":[139,184],"12(q15q22)":[141],"pre-chemotherapy":[144],"sample,":[145],"10":[150],"patient":[157],"subsequently":[158],"developed":[159],"metastatic":[160],"nodules":[161],"her":[163],"lungs,":[164],"histology":[166],"which":[168],"identical":[170],"pattern":[172],"to":[173,179],"pattern,":[176],"appeared":[178],"12(q15q22).":[186],"These":[187],"results":[188,193],"are":[189,201],"consistent":[190],"published":[192],"8q":[198],"associated":[202],"an":[204],"unfavorable":[205],"prognosis.":[206]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}