{"id":"https://openalex.org/W2058334346","doi":"https://doi.org/10.1371/journal.pone.0005925","title":"Quantification of Cytokeratin 5 mRNA Expression in the Circulation of Healthy Human Subjects and after Lung Transplantation","display_name":"Quantification of Cytokeratin 5 mRNA Expression in the Circulation of Healthy Human Subjects and after Lung Transplantation","publication_year":2009,"publication_date":"2009-06-15","ids":{"openalex":"https://openalex.org/W2058334346","doi":"https://doi.org/10.1371/journal.pone.0005925","mag":"2058334346","pmid":"https://pubmed.ncbi.nlm.nih.gov/19529775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2691992"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0005925","doi":"https://doi.org/10.1371/journal.pone.0005925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005925","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005925&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005925&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048777528","display_name":"Derek W. Nickerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210134385","display_name":"Mattel Children's Hospital","ror":"https://ror.org/04p5baq95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4210134385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek W. Nickerson","raw_affiliation_strings":["Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210134385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061198124","display_name":"Angela P. Presson","orcid":"https://orcid.org/0000-0001-7400-3923","observed_orcids":["https://orcid.org/0000-0001-7400-3923"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210134385","display_name":"Mattel Children's Hospital","ror":"https://ror.org/04p5baq95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4210134385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela P. Presson","raw_affiliation_strings":["Department of Biostatistics, University of California Los Angeles, Los Angeles, California, United States of America","Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210134385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010830379","display_name":"STEPHEN S WEIGT","orcid":"https://orcid.org/0000-0001-5351-8936","observed_orcids":["https://orcid.org/0000-0001-5351-8936"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S. Weigt","raw_affiliation_strings":["Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036172939","display_name":"Aric L. Gregson","orcid":"https://orcid.org/0000-0001-6806-0868","observed_orcids":["https://orcid.org/0000-0001-6806-0868"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aric L. Gregson","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019397106","display_name":"John A. Belperio","orcid":"https://orcid.org/0000-0003-2379-5486","observed_orcids":["https://orcid.org/0000-0003-2379-5486"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Belperio","raw_affiliation_strings":["Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087202502","display_name":"Brigitte N. Gomperts","orcid":"https://orcid.org/0000-0002-1809-723X","observed_orcids":["https://orcid.org/0000-0002-1809-723X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210134385","display_name":"Mattel Children's Hospital","ror":"https://ror.org/04p5baq95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4210134385"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brigitte N. Gomperts","raw_affiliation_strings":["Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mattel Children's Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210134385"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087202502"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210134385"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.19164413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"4","issue":"6","first_page":"e5925","last_page":"e5925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratin-5","display_name":"keratin 5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.7369999885559082},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6439999938011169},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/lung-function-recovery","display_name":"lung function recovery","score":0.7400000095367432},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.8770959377288818},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6448770761489868},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6284757852554321},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6056689620018005},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.5367494821548462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5089318752288818},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4846389889717102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45658156275749207},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42314350605010986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4037971496582031},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3689095973968506},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33294785022735596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32341933250427246},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.30474501848220825},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.23044875264167786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053555","descriptor_name":"Keratin-5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0005925","doi":"https://doi.org/10.1371/journal.pone.0005925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005925","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005925&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2691992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2691992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19529775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19529775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:44e89d3f879c4815b49214258302ff53","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/44e89d3f879c4815b49214258302ff53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 6, p e5925 (2009)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2t05t6n8","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2t05t6n8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS one, vol 4, iss 6","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2t05t6n8","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2t05t6n8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 4, iss 6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0005925","doi":"https://doi.org/10.1371/journal.pone.0005925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005925","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005925&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5078587990","display_name":"Cytokine Regulation of the Pulmonary Epithelium","funder_award_id":"K08HL074229","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306606","display_name":"American Thoracic Society","ror":"https://ror.org/0547sz392"},{"id":"https://openalex.org/F4320310320","display_name":"COPD Foundation","ror":"https://ror.org/02qfkky73"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058334346.pdf","grobid_xml":"https://content.openalex.org/works/W2058334346.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1570160369","https://openalex.org/W2001675896","https://openalex.org/W2017298826","https://openalex.org/W2048514182","https://openalex.org/W2052687680","https://openalex.org/W2068527759","https://openalex.org/W2077658669","https://openalex.org/W2107277218","https://openalex.org/W2108626209","https://openalex.org/W2141041714","https://openalex.org/W2143314514","https://openalex.org/W2147630590","https://openalex.org/W2170408009","https://openalex.org/W2171324765","https://openalex.org/W4244646784","https://openalex.org/W4313642562"],"related_works":["https://openalex.org/W7095206725","https://openalex.org/W2992739726","https://openalex.org/W2556825488","https://openalex.org/W608077586","https://openalex.org/W1606809927","https://openalex.org/W2280474611","https://openalex.org/W2080761576","https://openalex.org/W2106082365","https://openalex.org/W4307865155","https://openalex.org/W1570160369"],"abstract_inverted_index":{"BACKGROUND:":[0],"Circulating":[1],"epithelial":[2,25,73,107,227],"progenitor":[3,26,74,108,228],"cells":[4,27],"are":[5],"important":[6,39],"for":[7,40,225],"repair":[8,41],"of":[9,17,42,65,98,105,218,246,250],"the":[10,43,247],"airway":[11,44,259],"epithelium":[12],"in":[13,32,115,119,129,141,145,163,169,199,235],"a":[14,101,158,188,222,244],"mouse":[15],"model":[16],"tracheal":[18],"transplantation.":[19,83],"We":[20],"therefore":[21,241],"hypothesized":[22,70],"that":[23,71,147],"circulating":[24,72,106,194,226],"would":[28],"also":[29],"be":[30,38],"present":[31],"normal":[33,134],"human":[34,117,135,176],"subjects":[35,136,177],"and":[36,61,67,125,128,181,254],"could":[37,77],"after":[45],"lung":[46,49,54,82,120,170,200,205,236,251],"injury.":[47,260],"As":[48],"transplantation":[50],"is":[51,57],"associated":[52],"with":[53,203,232,258],"injury,":[55],"which":[56],"severe":[58],"early":[59],"on":[60],"exacerbated":[62],"during":[63],"episodes":[64],"infection":[66],"rejection,":[68],"we":[69],"cell":[75],"levels":[76,97,112,168,198],"predict":[78],"clinical":[79,248],"outcome":[80,249],"following":[81],"METHODOLOGY/PRINCIPAL":[84],"FINDINGS:":[85],"Quantitative":[86],"Real":[87],"Time":[88],"PCR":[89],"was":[90,157,187],"performed":[91],"to":[92,174,182],"determine":[93],"peripheral":[94],"blood":[95],"mRNA":[96,166,197],"cytokeratin":[99,139,164,195,219],"5,":[100],"previously":[102],"characterized":[103],"marker":[104,224],"cells.":[109],"Cytokeratin":[110],"5":[111,140,165,196,220],"were":[113,148],"evaluated":[114],"healthy":[116,175],"subjects,":[118],"transplant":[121,131,171,184,201,237,252],"recipients":[122,202],"immediately":[123],"post-transplant":[124],"serially":[126],"thereafter,":[127],"heart":[130,183],"recipients.":[132,185,238],"All":[133],"examined":[137],"expressed":[138],"their":[142],"buffy":[143],"coat":[144],"amounts":[146],"not":[149],"significantly":[150],"influenced":[151],"by":[152,209],"age":[153],"or":[154],"gender.":[155],"There":[156,186],"profound,":[159],"statistically":[160],"significant":[161],"decrease":[162],"expression":[167],"patients":[172,253,257],"compared":[173],"(p":[178],"=":[179,214],"3.1x10(-13))":[180],"moderate":[189],"negative":[190],"correlation":[191],"between":[192],"improved":[193,210],"recovering":[204],"function,":[206],"as":[207,243],"measured":[208],"FEV1":[211],"values":[212],"(rho":[213],"-0.39).":[215],"CONCLUSIONS/SIGNIFICANCE:":[216],"Levels":[217],"mRNA,":[221],"proxy":[223],"cells,":[229],"inversely":[230],"correlated":[231],"disease":[233],"status":[234],"It":[239],"may":[240],"serve":[242],"biomarker":[245],"potentially":[255],"other":[256]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}