{"id":"https://openalex.org/W2058232002","doi":"https://doi.org/10.1358/dot.2007.43.9.1112980","title":"Vorinostat in cutaneous T-cell lymphoma","display_name":"Vorinostat in cutaneous T-cell lymphoma","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2058232002","doi":"https://doi.org/10.1358/dot.2007.43.9.1112980","mag":"2058232002","pmid":"https://pubmed.ncbi.nlm.nih.gov/17940636"},"language":"en","primary_location":{"id":"doi:10.1358/dot.2007.43.9.1112980","doi":"https://doi.org/10.1358/dot.2007.43.9.1112980","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2007.43.9.1112980","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030460763","display_name":"Madeleine A. Duvic","orcid":"https://orcid.org/0000-0002-8971-4565","observed_orcids":["https://orcid.org/0000-0002-8971-4565"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duvic, M.","raw_affiliation_strings":["Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. mduvic@mdanderson.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. mduvic@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054880388","display_name":"Jenny Vu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vu, J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1699,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.98252388,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"43","issue":"9","first_page":"585","last_page":"585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/sezary-syndrome","display_name":"S\u00e9zary syndrome","score":0.8880000114440918},{"id":"https://openalex.org/keywords/large-cell-transformation","display_name":"large cell transformation","score":0.906000018119812},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.671999990940094},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5009999871253967},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4959999918937683},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6019999980926514},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.621999979019165},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5929999947547913},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.9758905172348022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9103075861930847},{"id":"https://openalex.org/C2776780870","wikidata":"https://www.wikidata.org/wiki/Q5196687","display_name":"Cutaneous T-cell lymphoma","level":4,"score":0.7015974521636963},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5484007000923157},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.518523097038269},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.49303194880485535},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4572373032569885},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4567914605140686},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43784815073013306},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40890082716941833},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.40082037448883057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39014381170272827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37988531589508057},{"id":"https://openalex.org/C2777756187","wikidata":"https://www.wikidata.org/wiki/Q1891209","display_name":"Mycosis fungoides","level":3,"score":0.2919289469718933},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.09366005659103394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1358/dot.2007.43.9.1112980","doi":"https://doi.org/10.1358/dot.2007.43.9.1112980","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2007.43.9.1112980","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},{"id":"pmid:17940636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17940636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of today (Barcelona, Spain : 1998)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097056962","https://openalex.org/W1530282402","https://openalex.org/W1968568016","https://openalex.org/W2336192459","https://openalex.org/W2156771941","https://openalex.org/W1968218944","https://openalex.org/W7015946313","https://openalex.org/W2380036341","https://openalex.org/W2149379768","https://openalex.org/W4233171904"],"abstract_inverted_index":{"Histone":[0],"deacetylase":[1],"inhibitors":[2],"(HDAC-Is)":[3],"are":[4,23],"a":[5,17,171],"novel":[6],"class":[7],"of":[8,19,33,60,116,124,144,173],"small":[9],"molecules":[10],"being":[11],"evaluated":[12],"in":[13,64,98,126,153,170,175],"clinical":[14,176],"trials":[15],"for":[16,58],"number":[18],"different":[20],"malignancies.":[21],"HDAC-Is":[22],"able":[24],"to":[25],"induce":[26],"differentiation,":[27],"apoptosis":[28],"and/or":[29],"cell":[30,134],"cycle":[31],"arrest":[32],"malignant":[34],"cells":[35],"selectively.":[36],"Vorinostat":[37,84,107],"(Zolinza,":[38],"Merck":[39],"&":[40],"Co.,":[41],"Whitehouse":[42],"Station,":[43],"NJ,":[44],"USA)":[45],"is":[46],"the":[47,52,61],"first":[48],"HDAC-I":[49],"approved":[50],"by":[51],"U.S.":[53],"Food":[54],"and":[55,90,95,110,136,150,162],"Drug":[56],"Administration":[57],"treatment":[59],"cutaneous":[62,67],"manifestations":[63],"patients":[65,129],"with":[66,119,130,155],"T-cell":[68],"lymphoma":[69],"(CTCL)":[70],"who":[71],"have":[72,165],"progressive,":[73],"persistent":[74],"or":[75,79,167],"recurrent":[76],"disease":[77],"on":[78],"following":[80],"two":[81,103],"systemic":[82],"therapies.":[83],"was":[85,108],"active":[86],"against":[87],"solid":[88],"tumors":[89],"hematologic":[91],"malignancies":[92],"as":[93,159],"intravenous":[94],"oral":[96,114],"preparations":[97],"phase":[99,104],"I":[100],"development.":[101],"In":[102],"II":[105],"trials,":[106],"safe":[109],"effective":[111],"at":[112],"an":[113,120],"dose":[115],"400":[117],"mg/day":[118],"overall":[121],"response":[122],"rate":[123],"30-31%":[125],"refractory":[127],"advanced":[128],"CTCL":[131],"including":[132],"large":[133],"transformation":[135],"Sezary":[137],"syndrome.":[138],"The":[139],"most":[140],"frequent":[141],"side":[142],"effects":[143,169],"vorinostat":[145],"include":[146],"gastrointestinal":[147],"symptoms,":[148],"fatigue":[149],"thrombocytopenia.":[151],"Vorinostat,":[152],"combination":[154],"other":[156],"agents":[157],"such":[158],"radiation":[160],"therapy":[161],"chemotherapy,":[163],"can":[164],"synergistic":[166],"additive":[168],"variety":[172],"cancers":[174],"trials.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}