{"id":"https://openalex.org/W2058101005","doi":"https://doi.org/10.1093/jb/mvm016","title":"Characterization of a Major Secretory Protein in the Cane Toad (Bufo marinus) Choroid Plexus as an Amphibian Lipocalin-type Prostaglandin D Synthase","display_name":"Characterization of a Major Secretory Protein in the Cane Toad (Bufo marinus) Choroid Plexus as an Amphibian Lipocalin-type Prostaglandin D Synthase","publication_year":2006,"publication_date":"2006-12-14","ids":{"openalex":"https://openalex.org/W2058101005","doi":"https://doi.org/10.1093/jb/mvm016","mag":"2058101005","pmid":"https://pubmed.ncbi.nlm.nih.gov/17167040"},"language":"en","primary_location":{"id":"doi:10.1093/jb/mvm016","doi":"https://doi.org/10.1093/jb/mvm016","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvm016","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035407022","display_name":"Daisuke Irikura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"D. Irikura","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050579291","display_name":"Takashi Inui","orcid":"https://orcid.org/0000-0001-7479-7700","observed_orcids":["https://orcid.org/0000-0001-7479-7700"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"T. Inui","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082001516","display_name":"Carsten Theodor Beuckmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"C. T. Beuckmann","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008798441","display_name":"Kosuke Aritake","orcid":"https://orcid.org/0000-0002-7441-7955","observed_orcids":["https://orcid.org/0000-0002-7441-7955"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"K. Aritake","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047084300","display_name":"Gerhard Schreiber","orcid":"https://orcid.org/0000-0003-1178-1802","observed_orcids":["https://orcid.org/0000-0003-1178-1802"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"G. Schreiber","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Miyano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"M. Miyano","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004349096","display_name":"Tsuyoshi Inoue A","orcid":"https://orcid.org/0000-0001-5337-5066","observed_orcids":["https://orcid.org/0000-0001-5337-5066"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":false,"raw_author_name":"T. Inoue","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060772179","display_name":"Yoshiro Urade","orcid":"https://orcid.org/0000-0002-6580-5497","observed_orcids":["https://orcid.org/0000-0002-6580-5497"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["AU","JP"],"is_corresponding":true,"raw_author_name":"Y. Urade","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan; 2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan; 3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia; and the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"]},{"raw_affiliation_string":"2 Structural Biophysics Laboratory, RIKEN Harima Institute, 1-1-1 Kouto, Sayo, Hyougo, 679-5148, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"3 Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan","institution_ids":[]},{"raw_affiliation_string":"the 4 Department of Engineering Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060772179"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210110652","https://openalex.org/I98285908"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.381,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63747376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"141","issue":"2","first_page":"173","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.1526000052690506,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.07440000027418137,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipocalin-type-prostaglandin-d-synthase","display_name":"lipocalin-type prostaglandin D synthase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rhinella-marina","display_name":"Rhinella marina","score":0.9739999771118164},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9020000100135803},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.878000020980835},{"id":"https://openalex.org/keywords/thyroid-hormone-binding","display_name":"thyroid hormone binding","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostaglandin-h2","display_name":"prostaglandin H2","score":0.7609999775886536},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5870000123977661},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/catalytic-residues","display_name":"catalytic residues","score":0.6570000052452087},{"id":"https://openalex.org/keywords/binding-pocket","display_name":"binding pocket","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2778166480","wikidata":"https://www.wikidata.org/wiki/Q6453151","display_name":"Toad","level":2,"score":0.9656000733375549},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.610094428062439},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.5546249747276306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5145198702812195},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4272312521934509},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.4196883738040924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3282473683357239},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3203277587890625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2742513418197632},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12473812699317932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001654","descriptor_name":"Bile Pigments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002024","descriptor_name":"Bufo marinus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jb/mvm016","doi":"https://doi.org/10.1093/jb/mvm016","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvm016","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:17167040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17167040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.959.9276","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.959.9276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.oxfordjournals.org/content/141/2/173.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:jbiochem:mvm016v1","doi":null,"is_oa":false,"landing_page_url":"http://jb.oxfordjournals.org/cgi/content/short/mvm016v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W145482169","https://openalex.org/W1454091905","https://openalex.org/W1493282932","https://openalex.org/W1513436357","https://openalex.org/W1554005852","https://openalex.org/W1657697319","https://openalex.org/W1883680853","https://openalex.org/W1965859012","https://openalex.org/W1965946053","https://openalex.org/W1977147294","https://openalex.org/W1989624036","https://openalex.org/W1997388462","https://openalex.org/W1998291307","https://openalex.org/W1999183933","https://openalex.org/W2027423369","https://openalex.org/W2040141270","https://openalex.org/W2061657254","https://openalex.org/W2065013860","https://openalex.org/W2074947829","https://openalex.org/W2080165605","https://openalex.org/W2081004376","https://openalex.org/W2082241899","https://openalex.org/W2086451539","https://openalex.org/W2087936588","https://openalex.org/W2088345052","https://openalex.org/W2109899602","https://openalex.org/W2138498116","https://openalex.org/W2140740981","https://openalex.org/W2161283315","https://openalex.org/W2166535160"],"related_works":["https://openalex.org/W7100764145","https://openalex.org/W2081004376","https://openalex.org/W2792120985","https://openalex.org/W1486211103","https://openalex.org/W1999183933","https://openalex.org/W2307975384","https://openalex.org/W3209131440","https://openalex.org/W2612077326","https://openalex.org/W1976219478","https://openalex.org/W2950321735"],"abstract_inverted_index":{"Here":[0],"we":[1],"report":[2],"the":[3,14,67,74,82,93,98,108,131,143,151,163,170,174,185],"enzymatic":[4],"and":[5,33,41,52,137,166,199],"ligand-binding":[6,197],"properties":[7],"of":[8,17,76,92,102,120,130,150,191],"a":[9,127,158,167,189,194,202],"major":[10],"secretory":[11],"protein":[12,23,46,64,95,133,187],"in":[13,37,73,162,169],"choroid":[15],"plexus":[16],"cane":[18],"toad,":[19],"Bufo":[20],"marinus,":[21],"whose":[22],"is":[24,34,188],"homologous":[25],"with":[26,55,193,201],"lipocalin-type":[27],"prostaglandin":[28],"(PG)":[29],"D":[30],"synthase":[31],"(L-PGDS)":[32],"recombinantly":[35],"expressed":[36],"Xenopus":[38],"A6":[39],"cells":[40],"Escherichia":[42],"coli.":[43],"The":[44,62,85,146],"toad":[45,63,94,132,152,186],"bound":[47],"all-trans":[48],"retinal,":[49],"bile":[50],"pigment,":[51],"thyroid":[53],"hormones":[54],"high":[56],"affinities":[57],"(K(d)=0.17":[58],"to":[59,81,179],"2.00":[60],"microM).":[61],"also":[65],"catalysed":[66],"L-PGDS":[68,104,192],"activity,":[69],"which":[70],"was":[71,96,113],"accelerated":[72],"presence":[75],"GSH":[77],"or":[78],"DTT,":[79],"similar":[80],"mammalian":[83],"enzyme.":[84],"K(m)":[86],"value":[87],"for":[88,142,173],"PGH(2)":[89],"(17":[90],"microM)":[91],"almost":[97],"same":[99],"as":[100],"that":[101,119,135,184],"rat":[103,121],"(14":[105],"microM),":[106],"whereas":[107],"turnover":[109,164],"number":[110,165],"(6":[111],"min(-1))":[112],"approximately":[114],"28":[115],"fold":[116,160],"lower":[117],"than":[118],"L-PGDS.":[122],"Site-directed":[123],"mutagenesis":[124],"based":[125],"on":[126],"modeled":[128],"structure":[129],"revealed":[134],"Cys(59)":[136],"Thr(61)":[138],"residues":[139],"were":[140],"crucial":[141],"PGDS":[144,175],"activity.":[145],"quadruple":[147],"Gly(39)Ser/Ala(75)Ser/Ser(140)Thr/Phe(142)Tyr":[148],"mutant":[149],"protein,":[153],"resembling":[154],"mouse":[155],"L-PGDS,":[156],"showed":[157],"1.6":[159],"increase":[161],"shift":[168],"optimum":[171],"pH":[172],"activity":[176],"from":[177],"9.0":[178],"8.5.":[180],"Our":[181],"results":[182],"suggest":[183],"prototype":[190],"highly":[195],"functional":[196],"pocket":[198],"yet":[200],"primitive":[203],"catalytic":[204],"pocket.":[205]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}