{"id":"https://openalex.org/W2058097318","doi":"https://doi.org/10.1177/153303460200100509","title":"Effect of Electrochemotherapy on Muscle and Skin","display_name":"Effect of Electrochemotherapy on Muscle and Skin","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2058097318","doi":"https://doi.org/10.1177/153303460200100509","mag":"2058097318","pmid":"https://pubmed.ncbi.nlm.nih.gov/12625764"},"language":"en","primary_location":{"id":"doi:10.1177/153303460200100509","doi":"https://doi.org/10.1177/153303460200100509","is_oa":true,"landing_page_url":"https://doi.org/10.1177/153303460200100509","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/153303460200100509","source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research &amp; Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/153303460200100509","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057362562","display_name":"Richard F. Heller","orcid":"https://orcid.org/0000-0003-1899-3859","observed_orcids":["https://orcid.org/0000-0003-1899-3859"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Heller","raw_affiliation_strings":["Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","Department of Surgery University of South Florida College of Medicine Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Surgery University of South Florida College of Medicine Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324164","display_name":"Domenico Coppola","orcid":"https://orcid.org/0000-0001-9090-1205","observed_orcids":["https://orcid.org/0000-0001-9090-1205","https://orcid.org/0009-0008-3540-2014"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenico Coppola","raw_affiliation_strings":["Department of Interdisciplinary Oncology Moffitt Cancer Center and Research Institute and University of South Florida College of Medicine Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interdisciplinary Oncology Moffitt Cancer Center and Research Institute and University of South Florida College of Medicine Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060093851","display_name":"Carlos Pottinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Pottinger","raw_affiliation_strings":["Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103742567","display_name":"Richard  A. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gilbert","raw_affiliation_strings":["Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","College of Engineering University of South Florida Tampa, FL 33620, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"College of Engineering University of South Florida Tampa, FL 33620, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021553715","display_name":"Mark J. Jaroszeski","orcid":"https://orcid.org/0000-0003-1908-311X","observed_orcids":["https://orcid.org/0000-0003-1908-311X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Jaroszeski","raw_affiliation_strings":["Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","Department of Surgery University of South Florida College of Medicine Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Delivery University of South Florida Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Surgery University of South Florida College of Medicine Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057362562"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.8531,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.6954023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"5","first_page":"385","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrochemotherapy","display_name":"electrochemotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.847000002861023},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/skin-necrosis","display_name":"skin necrosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/muscle-necrosis","display_name":"muscle necrosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/limb-function","display_name":"limb function","score":0.7680000066757202},{"id":"https://openalex.org/keywords/skin-malignancies","display_name":"skin malignancies","score":0.6449999809265137},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.6729999780654907},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2777108052","wikidata":"https://www.wikidata.org/wiki/Q3137263","display_name":"Electrochemotherapy","level":4,"score":0.994225025177002},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.8932662010192871},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.857437252998352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5831924676895142},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.5573287010192871},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4949182868003845},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41604575514793396},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41219115257263184},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3314233422279358},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3308880925178528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2561047375202179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22252866625785828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17878484725952148},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/153303460200100509","doi":"https://doi.org/10.1177/153303460200100509","is_oa":true,"landing_page_url":"https://doi.org/10.1177/153303460200100509","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/153303460200100509","source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research &amp; Treatment","raw_type":"journal-article"},{"id":"pmid:12625764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in cancer research & treatment","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/153303460200100509","doi":"https://doi.org/10.1177/153303460200100509","is_oa":true,"landing_page_url":"https://doi.org/10.1177/153303460200100509","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/153303460200100509","source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research &amp; Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5498894300","display_name":"ELECTROCHEMOTHERAPY FOR TREATING SOFT TISSUE SARCOMAS","funder_award_id":"5r01ca076181-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8940639784","display_name":null,"funder_award_id":"R01 CA76181","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310847","display_name":"University of South Florida","ror":"https://ror.org/032db5x82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058097318.pdf","grobid_xml":"https://content.openalex.org/works/W2058097318.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1544026458","https://openalex.org/W1963551591","https://openalex.org/W1968285225","https://openalex.org/W1968521513","https://openalex.org/W1971292845","https://openalex.org/W1976339696","https://openalex.org/W1978542226","https://openalex.org/W1979908488","https://openalex.org/W1984215847","https://openalex.org/W1997178536","https://openalex.org/W2034688094","https://openalex.org/W2044686244","https://openalex.org/W2045062389","https://openalex.org/W2052199470","https://openalex.org/W2056104198","https://openalex.org/W2059777861","https://openalex.org/W2061703524","https://openalex.org/W2064758943","https://openalex.org/W2068361492","https://openalex.org/W2075010947","https://openalex.org/W2078232861","https://openalex.org/W2090087191","https://openalex.org/W2100820352","https://openalex.org/W2146362841","https://openalex.org/W2157455777","https://openalex.org/W2328333669","https://openalex.org/W2331285763","https://openalex.org/W2405300882","https://openalex.org/W2415343827","https://openalex.org/W2482358093","https://openalex.org/W4237253263"],"related_works":["https://openalex.org/W4407052385","https://openalex.org/W2170302051","https://openalex.org/W2111409695","https://openalex.org/W1984215847","https://openalex.org/W23588382","https://openalex.org/W2313033735","https://openalex.org/W2886659159","https://openalex.org/W7132099174","https://openalex.org/W2515052152","https://openalex.org/W1722610957"],"abstract_inverted_index":{"The":[0,67,79,110],"efficient":[1],"delivery":[2],"of":[3,14,17,28,43,50,64,74,82,97],"drugs":[4],"to":[5,24],"tumors":[6],"is":[7],"an":[8],"important":[9],"tool":[10],"for":[11,61],"the":[12,26,31,41,72,93,98,128,139],"treatment":[13,129],"a":[15],"variety":[16],"cancers.":[18],"Electric":[19],"pulses":[20],"have":[21,52],"been":[22,37,53],"shown":[23],"facilitate":[25],"uptake":[27],"molecules":[29],"through":[30],"cell":[32],"membrane.":[33],"This":[34],"procedure":[35],"has":[36],"successful":[38],"in":[39,55,92],"increasing":[40],"effectiveness":[42],"anti-tumor":[44],"agents":[45],"(electrochemotherapy;":[46],"ECT).":[47],"Response":[48],"rates":[49],">80%":[51],"obtained":[54],"both":[56],"animal":[57],"and":[58,118,130,132],"human":[59],"trials":[60],"several":[62],"types":[63],"skin":[65,131],"malignancies.":[66],"study":[68],"reported":[69],"here":[70],"examined":[71,114],"effect":[73],"ECT":[75],"on":[76],"normal":[77],"tissue.":[78],"hind":[80],"limbs":[81],"Sprague":[83],"Dawley":[84],"rats":[85],"were":[86,113],"treated":[87,111],"with":[88],"1-3":[89],"electroporation":[90],"sequences":[91],"presence":[94],"or":[95,107],"absence":[96],"drug":[99],"(bleomycin)":[100],"which":[101],"was":[102,124,135],"administered":[103],"at":[104,138],"4,":[105],"8":[106],"16":[108],"units/ml.":[109],"sites":[112],"histologically":[115],"3,":[116],"14":[117],"56":[119],"days":[120],"later.":[121],"Limb":[122],"function":[123],"not":[125],"affected":[126],"by":[127],"muscle":[133],"necrosis":[134],"only":[136],"seen":[137],"higher":[140],"doses.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
